| UniProt/SwissProt ID: | PPR3A_HUMAN |
| Description: | protein phosphatase 1, regulatory subunit 3A [Source:HGNC Symbol;Acc:9291] |
| Location: | chr7 q31.1 |
| Node attribute: | phosphotase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T939 | VENAVtTMASQ | PhosphoSitePlus | |
| S46 | PSRRGsDSSED | PhosphoSitePlus; HPRD; RegPhos | |
| S46 | PSRRGsDSSED | RSK2(ISPK | RegPhos |
| S332 | LIRTRsTASRD | PhosphoSitePlus | |
| S1069 | NESLFsKYTNS | PhosphoSitePlus | |
| T940 | ENAVTtMASQP | PhosphoSitePlus | |
| S42 | FSPQPsRRGSD | GSK_group | RegPhos |
| S48 | RRGSDsSEDIY | PKA_group | phosphoELM; RegPhos |
| S46 | PSRRGsDSSED | RSK3 | RegPhos |
| S48 | RRGSDsSEDIY | RSK1 | RegPhos |
| T759 | KLPQEtARSDR | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S46 | PSRRGsDSSED | PKA_group | RegPhos |
| S38 | FQPGFsPQPSR | GSK_group | RegPhos |
| S46 | PSRRGsDSSED | RPS6KA1 | HPRD |
| S65 | GTRRVsFADSF | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S824 | KEETMsMYNPR | PhosphoSitePlus | |
| S261 | LKVKSsKEESS | RegPhos | |
| Y826 | ETMSMyNPRKT | PhosphoSitePlus | |
| S1066 | AQGNEsLFSKY | PhosphoSitePlus | |
| S48 | RRGSDsSEDIY | RSK-1 | phosphoELM |
| S65 | GTRRVsFADSF | PKA_group | phosphoELM; RegPhos |
| T822 | MEKEEtMSMYN | PhosphoSitePlus | |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S65 | SSGTRRVsFADSFGF | HPRD | |
| S65 | SSGTRRVsFADSFGF | PPP1R3A | HPRD |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000284601 | G554A | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974, 18428421 | ENSP00000284601 | S87G | COSMIC | Ovarian Cancer | 21720365 | ENSP00000284601 | S1059R | COSMIC | Pancreatic Cancer | ENSP00000284601 | A725E | COSMIC | Lung Cancer | 20668451 | ENSP00000284601 | S745Y | COSMIC | Lung Cancer | 20668451 | ENSP00000284601 | I1096T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000284601 | G612R | COSMIC | Prostate Cancer | 20668451 | ENSP00000284601 | V1102I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000284601 | S494L | COSMIC | Pancreatic Cancer | ENSP00000284601 | T286S | COSMIC | Pancreatic Cancer | ENSP00000284601 | Q325K | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000284601 | G397E | COSMIC | Melanoma | 21499247 | ENSP00000284601 | R486Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000284601 | R210C | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000284601 | S848Y | COSMIC | Lung Cancer | ENSP00000284601 | S894W | COSMIC | Melanoma | 21499247 | ENSP00000284601 | D306Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000284601 | S152C | COSMIC | Lung Cancer | 20668451 | ENSP00000284601 | H652Q | COSMIC | Lung Cancer | 20668451 | ENSP00000284601 | D440N | COSMIC | Melanoma | 21499247 | ENSP00000284601 | T501I | COSMIC | Pancreatic Cancer | ENSP00000284601 | R813C | COSMIC | Skin Cancer | 21984974 | ENSP00000284601 | L156F | COSMIC | Ovarian Cancer | 21720365 | ENSP00000284601 | P35S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000284601 | D580V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000284601 | K972N | COSMIC | Pancreatic Cancer | ENSP00000284601 | S42R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000284601 | V934L | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| PPR3A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PPR3A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KS6A3_HUMAN | PPR3A_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | PPR3A_HUMAN | kinase -> substrate | RegPhos |
| KS6A1_HUMAN | PPR3A_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| KS6A2_HUMAN | PPR3A_HUMAN | kinase -> substrate | RegPhos |
| PPR3A_HUMAN | PPR3A_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04910 | Insulin signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005977 | glycogen metabolic process | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |