Human Phosphorylation Mediated
                                 Signaling Transduction Network

Protein information

Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site

Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary

UniProt/SwissProt ID:	PPR3A_HUMAN
Description:	protein phosphatase 1, regulatory subunit 3A [Source:HGNC Symbol;Acc:9291]
Location:	chr7 q31.1
Node attribute:	phosphotase; substrate

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
T939	VENAVtTMASQ		PhosphoSitePlus
S46	PSRRGsDSSED		PhosphoSitePlus; HPRD; RegPhos
S46	PSRRGsDSSED	RSK2(ISPK	RegPhos
S332	LIRTRsTASRD		PhosphoSitePlus
S1069	NESLFsKYTNS		PhosphoSitePlus
T940	ENAVTtMASQP		PhosphoSitePlus
S42	FSPQPsRRGSD	GSK_group	RegPhos
S48	RRGSDsSEDIY	PKA_group	phosphoELM; RegPhos
S46	PSRRGsDSSED	RSK3	RegPhos
S48	RRGSDsSEDIY	RSK1	RegPhos
T759	KLPQEtARSDR		PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S46	PSRRGsDSSED	PKA_group	RegPhos
S38	FQPGFsPQPSR	GSK_group	RegPhos
S46	PSRRGsDSSED	RPS6KA1	HPRD
S65	GTRRVsFADSF		PhosphoSitePlus; HPRD; phosphoELM; RegPhos
S824	KEETMsMYNPR		PhosphoSitePlus
S261	LKVKSsKEESS		RegPhos
Y826	ETMSMyNPRKT		PhosphoSitePlus
S1066	AQGNEsLFSKY		PhosphoSitePlus
S48	RRGSDsSEDIY	RSK-1	phosphoELM
S65	GTRRVsFADSF	PKA_group	phosphoELM; RegPhos
T822	MEKEEtMSMYN		PhosphoSitePlus

Dephosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S65	SSGTRRVsFADSFGF		HPRD
S65	SSGTRRVsFADSFGF	PPP1R3A	HPRD

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000284601	G554A	Sjoblom2006, COSMIC, HPI	Breast Cancer	16959974, 18428421
ENSP00000284601	S87G	COSMIC	Ovarian Cancer	21720365
ENSP00000284601	S1059R	COSMIC	Pancreatic Cancer
ENSP00000284601	A725E	COSMIC	Lung Cancer	20668451
ENSP00000284601	S745Y	COSMIC	Lung Cancer	20668451
ENSP00000284601	I1096T	COSMIC	Ovarian Cancer	21720365
ENSP00000284601	G612R	COSMIC	Prostate Cancer	20668451
ENSP00000284601	V1102I	COSMIC	Ovarian Cancer	21720365
ENSP00000284601	S494L	COSMIC	Pancreatic Cancer
ENSP00000284601	T286S	COSMIC	Pancreatic Cancer
ENSP00000284601	Q325K	COSMIC	Head and Neck Cancer	21798893
ENSP00000284601	G397E	COSMIC	Melanoma	21499247
ENSP00000284601	R486Q	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000284601	R210C	COSMIC	Head and Neck Cancer	21798893
ENSP00000284601	S848Y	COSMIC	Lung Cancer
ENSP00000284601	S894W	COSMIC	Melanoma	21499247
ENSP00000284601	D306Y	COSMIC	Ovarian Cancer	21720365
ENSP00000284601	S152C	COSMIC	Lung Cancer	20668451
ENSP00000284601	H652Q	COSMIC	Lung Cancer	20668451
ENSP00000284601	D440N	COSMIC	Melanoma	21499247
ENSP00000284601	T501I	COSMIC	Pancreatic Cancer
ENSP00000284601	R813C	COSMIC	Skin Cancer	21984974
ENSP00000284601	L156F	COSMIC	Ovarian Cancer	21720365
ENSP00000284601	P35S	COSMIC	Ovarian Cancer	21720365
ENSP00000284601	D580V	COSMIC	Ovarian Cancer	21720365
ENSP00000284601	K972N	COSMIC	Pancreatic Cancer
ENSP00000284601	S42R	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000284601	V934L	COSMIC	Lung Cancer	20668451

Differential expressed protein

PPR3A_HUMAN is not differential expressed protein.

Hyperphosphorylation site

PPR3A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
KS6A3_HUMAN	PPR3A_HUMAN	kinase -> substrate	RegPhos
ZAGL2_HUMAN	PPR3A_HUMAN	kinase -> substrate	RegPhos
KS6A1_HUMAN	PPR3A_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
KS6A2_HUMAN	PPR3A_HUMAN	kinase -> substrate	RegPhos
PPR3A_HUMAN	PPR3A_HUMAN	phosphatase -> substrate	HPRD

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa04910	Insulin signaling pathway

Gene Ontology

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