Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRS7_HUMAN
Description:proteasome (prosome, macropain) 26S subunit, ATPase, 2 [Source:HGNC Symbol;Acc:9548]
Location:chr7 q22.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y111SEDPKyIINVKPhosphoSitePlus
Y432PRYMTyN____PhosphoSitePlus
Y174KPDVTySDVGGPhosphoSitePlus
Y429SATPRyMTYN_PhosphoSitePlus
Y4__MPDyLGADQPhosphoSitePlus
Y249ELVQKyVGEGAAAAPhosphoSitePlus
T63KINELtGIKESPhosphoSitePlus; HPRD
Y4GADQHPRD
T426AKFSAtPRYMTPhosphoSitePlus
T405RRKIAtEKDFLPhosphoSitePlus

Dephosphorylation site
PRS7_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000391211*434YCOSMICOvarian Cancer20826764
ENSP00000292644*434YCOSMICOvarian Cancer20826764
ENSP00000292644Q247HCOSMICHead and Neck Cancer21798893
ENSP00000292644E136KCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000292644Hepatocellular CarcinomaNormal vs. Cancercell lineUp518646787
ENSP00000292644Gastric CancerMetastasiscell lineUp1.717022644
ENSP00000292644Gastric CancerMetastasiscell lineUp1.717022644
ENSP00000292644Breast CancerCancer vs. Cancer (Non-TNBC vs. TNBC)cell lineUp20596302
ENSP00000292644Testicular CancerNormal vs. Cancercell lineUp18489135
ENSP00000292644Ovarian CancerTreatment (Paclitaxel-sensitive vs. Paclitaxel-resistant)cell lineDown0.02420858016

Hyperphosphorylation site
PRS7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A2_HUMANPRS7_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PRS7_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0022624proteasome accessory complexIEAcellular_component
GO:0005739mitochondrionIDAcellular_component
GO:0010467gene expressionTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0000075cell cycle checkpointTASbiological_process
GO:0006511ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0016787hydrolase activityIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0042590antigen processing and presentation of exogenous pTASbiological_process
GO:0006521regulation of cellular amino acid metabolic procesTASbiological_process
GO:0006200ATP catabolic processIDAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0051437positive regulation of ubiquitin-protein ligase acTASbiological_process
GO:0000502proteasome complexIDAcellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0019048virus-host interactionIEAbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0000209protein polyubiquitinationTASbiological_process
GO:0017111nucleoside-triphosphatase activityIEAmolecular_function
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0002479antigen processing and presentation of exogenous pTASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0016887ATPase activityIDAmolecular_function
GO:0034641cellular nitrogen compound metabolic processTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0000932cytoplasmic mRNA processing bodyISScellular_component
GO:0051436negative regulation of ubiquitin-protein ligase acTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0002474antigen processing and presentation of peptide antTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 clTASbiological_process
GO:0008233peptidase activityIEAmolecular_function
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process
GO:0030163protein catabolic processIEAbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0031145anaphase-promoting complex-dependent proteasomal uTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0042981regulation of apoptotic processTASbiological_process


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