Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PARK7_HUMAN
Description:parkinson protein 7 [Source:HGNC Symbol;Acc:16369]
Location:chr1 p36.23
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y67KKEGPyDVVVLHPRD; phosphoELM
T19AEEMEtVIPVDPhosphoSitePlus
Y139MNGGHyTYSENDJ-1_PfpIPhosphoSitePlus
S142GHYTYsENRVEHPRD
Y67KKEGPyDVVVLDJ-1_PfpIPhosphoSitePlus
Y141GGHYTySENRVDJ-1_PfpIPhosphoSitePlus

Dephosphorylation site
PARK7_HUMAN do not have dephosphorylation site.

Mutation site
PARK7_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000366708hepatitis C virusNormal vs. CancertissueDown0.318715028
ENSP00000366708Prostate CancerTreatment (none vs. bicalutamide treatment)cell lineUp1.317152098
ENSP00000366708Thyroid CarcinomaNormal vs. CancertissueUp3.217194741
ENSP00000366708papillary thyroid carcinomaNormal vs. CancertissueUp2.118665625
ENSP00000366708papillary thyroid carcinomaNormal vs. CancertissueUp1.818665625
ENSP00000366708hepatitis B virusNormal vs. CancertissueDown0.3217671684
ENSP00000366708hepatitis B virusNormal vs. Cancercell lineUp1.619626621
ENSP00000366708Lung CancerTreatment (none vs. Mitoxantrone resistance)cell lineUp1.217593620
ENSP00000366708Breast CancerNormal vs. CancertissueUp2.220005186
ENSP00000366708Breast CancerNormal vs. CancertissueUp1.420087651
ENSP00000366708Oral CancerNormal vs. CancertissueUp3.219691830
ENSP00000366708LeukemiaCancer vs. Cancer (subtype)tissueUp15501966
ENSP00000366708acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp1117655343
ENSP00000366708Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 21 hour)cell lineDown0.3415169874
ENSP00000366708Neoplasms by Histologic TypeCancer vs. Cancer (sporadic systemic lymphomas (SSLs) vs. primary CNS lymphomas(PCNSLs))cell lineDown18759588
ENSP00000366708Gastric CancerTreatment (none vs. drug-resistant)cell lineUp1.420625496
ENSP00000366708Esophageal CancerNormal vs. Cancercell lineDown0.3219090015
ENSP00000366708Esophageal CancerNormal vs. Cancercell lineDown0.3919090015
ENSP00000366708pancreatic ductal adenocarcinomaNormal vs. CancertissueUp17492507

Hyperphosphorylation site
PARK7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A2_HUMANPARK7_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANPARK7_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANPARK7_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PARK7_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006508proteolysisIEAbiological_process
GO:0043524negative regulation of neuron apoptotic processIDAbiological_process
GO:0051899membrane depolarizationIEAbiological_process
GO:0050727regulation of inflammatory responseISSbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0004601peroxidase activityIEAmolecular_function
GO:0060765regulation of androgen receptor signaling pathwayIDAbiological_process
GO:0003729mRNA bindingIDAmolecular_function
GO:0007005mitochondrion organizationIEAbiological_process
GO:0007005mitochondrion organizationISSbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0042743hydrogen peroxide metabolic processIEAbiological_process
GO:0070301cellular response to hydrogen peroxideIDAbiological_process
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0060081membrane hyperpolarizationIEAbiological_process
GO:0060548negative regulation of cell deathIDAbiological_process
GO:0008233peptidase activityIDAmolecular_function
GO:0032091negative regulation of protein bindingIDAbiological_process
GO:0006950response to stressIEAbiological_process
GO:0004601peroxidase activityISSmolecular_function
GO:0050727regulation of inflammatory responseIEAbiological_process
GO:0034599cellular response to oxidative stressIEAbiological_process
GO:0051920peroxiredoxin activityIEAmolecular_function
GO:0001963synaptic transmission, dopaminergicIEAbiological_process
GO:0060548negative regulation of cell deathIEAbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0005739mitochondrionIDAcellular_component
GO:0006914autophagyIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0051583dopamine uptake involved in synaptic transmissionIEAbiological_process
GO:0008344adult locomotory behaviorIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0043523regulation of neuron apoptotic processIDAbiological_process
GO:0007338single fertilizationIEAbiological_process
GO:0050821protein stabilizationIMPbiological_process
GO:2000277positive regulation of oxidative phosphorylation uIEAbiological_process
GO:2001237negative regulation of extrinsic apoptotic signaliIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008219cell deathIEAbiological_process


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