Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:UB2V1_HUMAN
Description:ubiquitin-conjugating enzyme E2 variant 1 [Source:HGNC Symbol;Acc:12494]
Location:chr20 q13.13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T109FVRFVtKINMNHPRD
T86FVRFVtKINMNHPRD
T42FVRFVtKINMNHPRD

Dephosphorylation site
UB2V1_HUMAN do not have dephosphorylation site.

Mutation site
UB2V1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000395264Gastric CancerMetastasiscell lineUp1.717022644
ENSP00000395264Gastric CancerMetastasiscell lineUp1.717022644

Hyperphosphorylation site
UB2V1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ANPRB_HUMANUB2V1_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANUB2V1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
UB2V1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0070423nucleotide-binding oligomerization domain containiTASbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0035370UBC13-UEV1A complexIDAcellular_component
GO:0008063Toll signaling pathwayTASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0005634nucleusTAScellular_component
GO:0016881acid-amino acid ligase activityIEAmolecular_function
GO:0000209protein polyubiquitinationTASbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0000151ubiquitin ligase complexIDAcellular_component
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIMPbiological_process
GO:0006282regulation of DNA repairTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031371ubiquitin conjugating enzyme complexIDAcellular_component
GO:0030154cell differentiationNASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenTASbiological_process
GO:0070534protein K63-linked ubiquitinationIDAbiological_process
GO:0006355regulation of transcription, DNA-dependentTASbiological_process


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