Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DDR1_HUMAN
Description:discoidin domain receptor tyrosine kinase 1 [Source:HGNC Symbol;Acc:2730]
Location:chrHSCHR6_MHC_COX p2
Node attribute:kinase; receptor; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y513LSNPAyRLLLAautocatalysis RegPhos
S496GNPPHsAPCVPPhosphoSitePlus
Y802LYAGDyYRVQGHPRD
Y881CPQGLyELMLRPkinase_TyrPhosphoSitePlus
Y520LLLATyARPPRPhosphoSitePlus
S45RTIPDsDISASPhosphoSitePlus
Y792MSRNLyAGDYYHPRD; phosphoELM
Y740GPTISyPMLLHPkinase_TyrPhosphoSitePlus
T519RLLLAtYARPPPhosphoSitePlus
S788ADFGMsRNLYAphosphoELM
Y792MSRNLyAGDYYautocatalysis RegPhos
Y796LYAGDyYRVQGautocatalysis RegPhos
S788ADFGMsRNLYAPkinase_TyrPhosphoSitePlus
Y803YAGDYyRVQGRHPRD
Y484REPPPyQEPRPPhosphoSitePlus
Y759LYAGDyYRVQGHPRD
Y792MSRNLyAGDYYPkinase_TyrPhosphoSitePlus
Y798MSRNLyAGDYYHPRD
Y703CMITDyMENGDPkinase_TyrPhosphoSitePlus
Y513LSNPAyRLLLAPhosphoSitePlus; phosphoELM; RegPhos
Y797YAGDYyRVQGRautocatalysis RegPhos
Y796LYAGDyYRVQGPkinase_TyrPhosphoSitePlus
Y797YAGDYyRVQGRPkinase_TyrPhosphoSitePlus
Y869QGRQVyLSRPPPkinase_TyrPhosphoSitePlus
Y797YAGDYyRVQGRHPRD; phosphoELM
Y760YAGDYyRVQGRHPRD
T469SVPGDtILINNCD34_antigenPhosphoSitePlus
Y755MSRNLyAGDYYHPRD
Y513LSNPAyRLLLADDR1HPRD; RegPhos
Y796LYAGDyYRVQGHPRD; phosphoELM
S631LCEVDsPQDLVPkinase_TyrPhosphoSitePlus

Dephosphorylation site
DDR1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000405039S496AHPILung Cancer17344846
ENSP00000365752S213CBIOMARTBreast Cancer21930507, 21930502
ENSP00000365751S213CBIOMARTBreast Cancer21930507, 21930502
ENSP00000406091S213CBIOMARTBreast Cancer21930507, 21930502
ENSP00000318217P392LCOSMICMelanoma21499247
ENSP00000318217S496AHPILung Cancer17344846
ENSP00000318217D825NCOSMICLung Cancer20668451
ENSP00000405039S213CBIOMARTBreast Cancer21930507, 21930502
ENSP00000365752S496AHPILung Cancer17344846
ENSP00000318217S372FCOSMICMelanoma19718025
ENSP00000318217R607QCOSMICMelanoma19718025
ENSP00000365753S213CBIOMARTBreast Cancer21930507, 21930502
ENSP00000318217R514CCOSMICOvarian Cancer21720365
ENSP00000407699S213CBIOMARTBreast Cancer21930507, 21930502
ENSP00000318217P606SCOSMICSkin Cancer21984974
ENSP00000318217R296CCOSMICBreast Cancer20668451
ENSP00000365759S213CBIOMARTBreast Cancer21930507, 21930502
ENSP00000318217S213CBIOMARTBreast Cancer21930507, 21930502
ENSP00000365754S213CBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
DDR1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y796Pkinase_TyrRNLYAGDyYRVQGRAcholangiocellular carcinoma21253578PhosphoSitePlus
Y513LLLSNPAyRLLLATYcholangiocellular carcinoma21253578PhosphoSitePlus
Y792Pkinase_TyrFGMSRNLyAGDYYRVcholangiocellular carcinoma21253578PhosphoSitePlus
Y797Pkinase_TyrNLYAGDYyRVQGRAVcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
CO1A1_HUMANDDR1_HUMANligand -> receptorHPMR
DDR1_HUMANZN606_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANXPO1_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANNDF1_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANHSFX1_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANZIC4_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANMBNL3_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANCDK4_HUMANkinase -> substrateRegPhos
DDR1_HUMANZNF32_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANNELFB_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANPER1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANDDR1_HUMANkinase -> substrateRegPhos
DDR1_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANIASPP_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANCHK1_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANPHB2_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANPOLK_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANFEV_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANDDR1_HUMANkinase -> substrateHPRD; RegPhos
DDR1_HUMANCDK2_HUMANkinase -> substrateRegPhos
DDR1_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANABI2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
DDR1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0060444branching involved in mammary gland duct morphogenIEAbiological_process
GO:0038063collagen-activated tyrosine kinase receptor signalIEAbiological_process
GO:0010715regulation of extracellular matrix disassemblyIEAbiological_process
GO:0038083peptidyl-tyrosine autophosphorylationIDAbiological_process
GO:0038062protein tyrosine kinase collagen receptor activityIDAmolecular_function
GO:0001558regulation of cell growthIEAbiological_process
GO:0005518collagen bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0007566embryo implantationIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0043583ear developmentIEAbiological_process
GO:0005576extracellular regionIEAcellular_component
GO:0007155cell adhesionTASbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0014909smooth muscle cell migrationIEAbiological_process
GO:0001952regulation of cell-matrix adhesionIEAbiological_process
GO:0060749mammary gland alveolus developmentIEAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0061302smooth muscle cell-matrix adhesionIEAbiological_process
GO:0004714transmembrane receptor protein tyrosine kinase actTASmolecular_function
GO:0007595lactationIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0044319wound healing, spreading of cellsIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function