Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RNF4_HUMAN
Description:ring finger protein 4 [Source:HGNC Symbol;Acc:10067]
Location:chr4 p16.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S101DDEELsRDRDVHPRD
Y189RYHPIyI____PhosphoSitePlus
S90QDHADsCVVSSHPRD
Y107RDRDVyVTTHTPhosphoSitePlus
T112YVTTHtPRNARPhosphoSitePlus
S95SCVVSsDDEELPhosphoSitePlus; HPRD; phosphoELM
S94DSCVVsSDDEEPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
RNF4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000315212K5QBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
RNF4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RNF4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK11_HUMANRNF4_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANRNF4_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RNF4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0090169regulation of spindle assemblyIMPbiological_process
GO:0070534protein K63-linked ubiquitinationIEAbiological_process
GO:0070936protein K48-linked ubiquitinationIEAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0043161proteasomal ubiquitin-dependent protein catabolic IMPbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0090234regulation of kinetochore assemblyIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030521androgen receptor signaling pathwayNASbiological_process
GO:0032184SUMO polymer bindingIEAmolecular_function
GO:0033142progesterone receptor bindingIEAmolecular_function
GO:0051865protein autoubiquitinationIEAbiological_process
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0030331estrogen receptor bindingIEAmolecular_function
GO:0085020protein K6-linked ubiquitinationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0003713transcription coactivator activityNASmolecular_function
GO:0005654nucleoplasmIEAcellular_component
GO:0046685response to arsenic-containing substanceIEAbiological_process
GO:0016605PML bodyIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0050681androgen receptor bindingIEAmolecular_function
GO:0004842ubiquitin-protein ligase activityIEAmolecular_function
GO:0031491nucleosome bindingIEAmolecular_function
GO:0016567protein ubiquitinationIEAbiological_process
GO:0070979protein K11-linked ubiquitinationIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function