Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NR4A1_HUMAN
Description:nuclear receptor subfamily 4, group A, member 1 [Source:HGNC Symbol;Acc:7980]
Location:chr12 q13.13
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S341VVRTDsLKGRRPKA_groupRegPhos
T143APSPStPSFQPErk2RegPhos
S351RGRLPsKPKQPAKT_groupRegPhos
S152QPPQLsPWDGSPhosphoSitePlus
S341VVRTDsLKGRRHPRD; RegPhos
S351RGRLPsKPKQPPhosphoSitePlus; phosphoELM
S351RGRLPsKPKQPRPS6KA5HPRD
S351RGRLPsKPKQPRPS6KA1HPRD
S351RGRLPsKPKQPRPS6KA3HPRD
S140PCSAPsPSTPSPhosphoSitePlus
S360QPPDAsPANLLPhosphoSitePlus
S351RGRLPsKPKQPPKA_groupRegPhos
S351RGRLPsKPKQPMSK1RegPhos
T143APSPStPSFQPMAPK1HPRD
S431GFAELsPADQDHormone_recepPhosphoSitePlus
T339KEVVRtDSLKGPhosphoSitePlus
S351RGRLPsKPKQPPKB_groupphosphoELM
S95SSSATsPASASPhosphoSitePlus
S351RGRLPsKPKQPRSK2RegPhos
S351RGRLPsKPKQPAKT1HPRD; RegPhos
T143APSPStPSFQPPhosphoSitePlus
S351RGRLPsKPKQPRSK3RegPhos
S201TGPSPsLAQSPHPRD

Dephosphorylation site
NR4A1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000243050A229TCOSMICHead and Neck Cancer21984974
ENSP00000378302A229TCOSMICHead and Neck Cancer21984974
ENSP00000378301A229TCOSMICHead and Neck Cancer21984974
ENSP00000378301S455CCOSMICHead and Neck Cancer21798893
ENSP00000378302S455CCOSMICHead and Neck Cancer21798893
ENSP00000243050S455CCOSMICHead and Neck Cancer21798893

Differential expressed protein
NR4A1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NR4A1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KS6A3_HUMANNR4A1_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANNR4A1_HUMANkinase -> substrateRegPhos
KS6A5_HUMANNR4A1_HUMANkinase -> substrateHPRD; RegPhos
KS6A2_HUMANNR4A1_HUMANkinase -> substrateRegPhos
MK07_HUMANNR4A1_HUMANkinase -> substrateKEGG
AKT1_HUMANNR4A1_HUMANkinase -> substrateHPRD; RegPhos
KS6A1_HUMANNR4A1_HUMANkinase -> substrateHPRD
MK01_HUMANNR4A1_HUMANkinase -> substrateHPRD
NR4A1_HUMANE2F1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0044344cellular response to fibroblast growth factor stimIMPbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0003677DNA bindingISSmolecular_function
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005667transcription factor complexIEAcellular_component
GO:0035924cellular response to vascular endothelial growth fIMPbiological_process
GO:0002042cell migration involved in sprouting angiogenesisIDAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0030522intracellular receptor mediated signaling pathwayTASbiological_process
GO:0004879ligand-activated sequence-specific DNA binding RNAIEAmolecular_function
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0001938positive regulation of endothelial cell proliferatIMPbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0071310cellular response to organic substanceIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0008270zinc ion bindingIEAmolecular_function
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0043401steroid hormone mediated signaling pathwayIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0005634nucleusISScellular_component
GO:0003707steroid hormone receptor activityIEAmolecular_function
GO:0043154negative regulation of cysteine-type endopeptidaseIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0035767endothelial cell chemotaxisIMPbiological_process
GO:0001077RNA polymerase II core promoter proximal region seIEAmolecular_function