Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KGP1_HUMAN
Description:protein kinase, cGMP-dependent, type I [Source:HGNC Symbol;Acc:9414]
Location:chr10 q11.23
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T59IGPRTtRAQGIPKC_alphaphosphoELM
T515GFGKKtWTFCGPkinasePhosphoSitePlus
S273VTREDsPSEDPcNMP_bindingPhosphoSitePlus
T517GKKTWtFCGTPPkinasePhosphoSitePlus
Y435DSKYLyMLMEAPkinasePhosphoSitePlus
T57VIRPAtQQAQKPRKCAHPRD
Y497LDHRGyAKLVDPkinasePhosphoSitePlus
Y433FKDSKyLYMLMPkinasePhosphoSitePlus
S51VLPVPsTHIGPMed4; HR1PhosphoSitePlus
S218MEFLKsVPTFQPhosphoSitePlus
T59IGPRTtRAQGIMed4PhosphoSitePlus
S65RAQGIsAEPQTPhosphoSitePlus
Y212IKHTEyMEFLKPhosphoSitePlus
Y247YENGEyIIRQGcNMP_bindingPhosphoSitePlus
S231PEEILsKLADVPhosphoSitePlus
T85AFRKFtKSERSPhosphoSitePlus

Dephosphorylation site
KGP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363092S570NDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
KGP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
KGP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KGP1_HUMANPPR17_HUMANkinase -> substrateHPRD
KGP1_HUMANCRIP2_HUMANkinase -> substrateHPRD
KGP1_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
KGP1_HUMANMK07_HUMANkinase -> substrateRobert H Newman (2013)
KGP1_HUMANSTF1_HUMANkinase -> substrateHPRD
KGP1_HUMANCREB1_HUMANkinase -> substrateHPRD
KGP1_HUMANSEPT3_HUMANkinase -> substrateHPRD
KGP1_HUMANGTF2I_HUMANkinase -> substrateHPRD
KPCA_HUMANKGP1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KGP1_HUMANGKAP1_HUMANkinase -> substrateHPRD
KGP1_HUMANGBRR1_HUMANkinase -> substrateHPRD
KGP1_HUMANTRPC3_HUMANkinase -> substrateHPRD
KGP1_HUMANRGS2_HUMANkinase -> substrateHPRD
KGP1_HUMANITPR1_HUMANkinase -> substrateHPRD
KGP1_HUMANKS6A2_HUMANkinase -> substrateRobert H Newman (2013)
KGP1_HUMANMDFI_HUMANkinase -> substrateRobert H Newman (2013)
KGP1_HUMANCFTR_HUMANkinase -> substrateHPRD
KGP1_HUMANBRCA1_HUMANkinase -> substrateRobert H Newman (2013)
KGP1_HUMANPLCB3_HUMANkinase -> substrateHPRD
KGP1_HUMANRYR1_HUMANkinase -> substrateHPRD
KGP1_HUMANVASP_HUMANkinase -> substrateHPRD
KGP1_HUMANMRVI1_HUMANkinase -> substrateHPRD
KGP1_HUMANPDE5A_HUMANkinase -> substrateHPRD
KGP1_HUMANOSTP_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04970Salivary secretion
hsa04730Long-term depression
hsa04740Olfactory transduction
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006468protein phosphorylationIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0030036actin cytoskeleton organizationTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0090331negative regulation of platelet aggregationIMPbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0001764neuron migrationIEAbiological_process
GO:0005246calcium channel regulator activityIDAmolecular_function
GO:0004692cGMP-dependent protein kinase activityIEAmolecular_function
GO:0016358dendrite developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030553cGMP bindingIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005794Golgi apparatusIEAcellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0043087regulation of GTPase activityIMPbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0005829cytosolTAScellular_component


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