Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SGK1_HUMAN
Description:serum/glucocorticoid regulated kinase 1 [Source:HGNC Symbol;Acc:10810]
Location:chr6 q23.2
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S78PSPPPsPSQQIMito_fiss_regPhosphoSitePlus
S422AFLGFsYAPPTPDPK1HPRD
S78PSPPPsPSQQIMAPK7HPRD; phosphoELM
T256NSTTStFCGTPPDK1RegPhos
T256NSTTStFCGTPPDK2RegPhos
S377FNPNVsGPNDLphosphoELM
S78PSPPPsPSQQIErk5RegPhos
S422AFLGFsYAPPTPDK-2phosphoELM
S422AFLGFsYAPPTPDK-1phosphoELM
Y124AEEVFyAVKVLMito_fiss_reg; PkinasePhosphoSitePlus
S401NSIGKsPDSVLHPRD
T256NSTTStFCGTPPDK-2phosphoELM
T256NSTTStFCGTPPDPK1HPRD
T369INKKItPPFNPPhosphoSitePlus
S422AFLGFsYAPPTNEK6HPRD; phosphoELM; RegPhos
T256NSTTStFCGTPPkinasePhosphoSitePlus
T256NSTTStFCGTPPDK-1phosphoELM
S377FNPNVsGPNDLNEK6HPRD; phosphoELM; RegPhos
S422AFLGFsYAPPTPkinase_CPhosphoSitePlus
S397EPVPNsIGKSPPkinase_CPhosphoSitePlus
S401NSIGKsPDSVLPkinase_CPhosphoSitePlus
S397EPVPNsIGKSPHPRD
S377FNPNVsGPNDLPkinase_CPhosphoSitePlus
S74MNANPsPPPSPMito_fiss_regPhosphoSitePlus
T256NSTTStFCGTPHPRD; RegPhos
S74MNANPsPPPSPHPRD
S422AFLGFsYAPPTPDK2RegPhos
S422AFLGFsYAPPTPDK1RegPhos
S422AFLGFsYAPPTHPRD; RegPhos
T369INKKItPPFNPPKA_groupphosphoELM; RegPhos
S78PSPPPsPSQQIErk5(MAPK7RegPhos

Dephosphorylation site
SGK1_HUMAN do not have dephosphorylation site.

Mutation site
SGK1_HUMAN do not have mutation site.

Differential expressed protein
SGK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SGK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SGK1_HUMANFOXO1_HUMANkinase -> substrateRegPhos
SGK1_HUMANGSK3B_HUMANkinase -> substrateRegPhos
SGK1_HUMANEAA1_HUMANkinase -> substrateHPRD; RegPhos
PDPK1_HUMANSGK1_HUMANkinase -> substrateRegPhos
SGK1_HUMANFOXO3_HUMANkinase -> substrateRegPhos
SGK1_HUMANBRAF_HUMANkinase -> substrateHPRD; RegPhos
SGK1_HUMANIRK1_HUMANkinase -> substrateRegPhos
SGK1_HUMANCREB1_HUMANkinase -> substrateHPRD; RegPhos
SGK1_HUMANMTA1_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANSGK1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
MK07_HUMANSGK1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
PDK2_HUMANSGK1_HUMANkinase -> substrateRegPhos
SGK1_HUMANNED4L_HUMANkinase -> substrateRegPhos
SGK1_HUMANM3K3_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANSGK1_HUMANkinase -> substrateRegPhos
SGK1_HUMANGSK3A_HUMANkinase -> substrateHPRD; RegPhos
SGK1_HUMANHD_HUMANkinase -> substrateRegPhos
SGK1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04960Aldosterone-regulated sodium reabsorption

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0015459potassium channel regulator activityTASmolecular_function
GO:0007154cell communicationIEAbiological_process
GO:0017080sodium channel regulator activityTASmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0017081chloride channel regulator activityTASmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0050790regulation of catalytic activityTASbiological_process
GO:0007616long-term memoryTASbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0042981regulation of apoptotic processTASbiological_process
GO:0032411positive regulation of transporter activityTASbiological_process
GO:0005246calcium channel regulator activityTASmolecular_function
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0008217regulation of blood pressureTASbiological_process
GO:0006950response to stressTASbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0035091phosphatidylinositol bindingIEAmolecular_function
GO:0001558regulation of cell growthTASbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0006814sodium ion transportTASbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0030334regulation of cell migrationTASbiological_process
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0070294renal sodium ion absorptionTASbiological_process
GO:0051090regulation of sequence-specific DNA binding transcTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0060453regulation of gastric acid secretionTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0042127regulation of cell proliferationTASbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23