| UniProt/SwissProt ID: | SGK1_HUMAN |
| Description: | serum/glucocorticoid regulated kinase 1 [Source:HGNC Symbol;Acc:10810] |
| Location: | chr6 q23.2 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S78 | PSPPPsPSQQI | Mito_fiss_reg | PhosphoSitePlus |
| S422 | AFLGFsYAPPT | PDPK1 | HPRD |
| S78 | PSPPPsPSQQI | MAPK7 | HPRD; phosphoELM |
| T256 | NSTTStFCGTP | PDK1 | RegPhos |
| T256 | NSTTStFCGTP | PDK2 | RegPhos |
| S377 | FNPNVsGPNDL | phosphoELM | |
| S78 | PSPPPsPSQQI | Erk5 | RegPhos |
| S422 | AFLGFsYAPPT | PDK-2 | phosphoELM |
| S422 | AFLGFsYAPPT | PDK-1 | phosphoELM |
| Y124 | AEEVFyAVKVL | Mito_fiss_reg; Pkinase | PhosphoSitePlus |
| S401 | NSIGKsPDSVL | HPRD | |
| T256 | NSTTStFCGTP | PDK-2 | phosphoELM |
| T256 | NSTTStFCGTP | PDPK1 | HPRD |
| T369 | INKKItPPFNP | PhosphoSitePlus | |
| S422 | AFLGFsYAPPT | NEK6 | HPRD; phosphoELM; RegPhos |
| T256 | NSTTStFCGTP | Pkinase | PhosphoSitePlus |
| T256 | NSTTStFCGTP | PDK-1 | phosphoELM |
| S377 | FNPNVsGPNDL | NEK6 | HPRD; phosphoELM; RegPhos |
| S422 | AFLGFsYAPPT | Pkinase_C | PhosphoSitePlus |
| S397 | EPVPNsIGKSP | Pkinase_C | PhosphoSitePlus |
| S401 | NSIGKsPDSVL | Pkinase_C | PhosphoSitePlus |
| S397 | EPVPNsIGKSP | HPRD | |
| S377 | FNPNVsGPNDL | Pkinase_C | PhosphoSitePlus |
| S74 | MNANPsPPPSP | Mito_fiss_reg | PhosphoSitePlus |
| T256 | NSTTStFCGTP | HPRD; RegPhos | |
| S74 | MNANPsPPPSP | HPRD | |
| S422 | AFLGFsYAPPT | PDK2 | RegPhos |
| S422 | AFLGFsYAPPT | PDK1 | RegPhos |
| S422 | AFLGFsYAPPT | HPRD; RegPhos | |
| T369 | INKKItPPFNP | PKA_group | phosphoELM; RegPhos |
| S78 | PSPPPsPSQQI | Erk5(MAPK7 | RegPhos |
| Dephosphorylation site |
| SGK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| SGK1_HUMAN do not have mutation site. |
| Differential expressed protein |
| SGK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SGK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SGK1_HUMAN | FOXO1_HUMAN | kinase -> substrate | RegPhos |
| SGK1_HUMAN | GSK3B_HUMAN | kinase -> substrate | RegPhos |
| SGK1_HUMAN | EAA1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| PDPK1_HUMAN | SGK1_HUMAN | kinase -> substrate | RegPhos |
| SGK1_HUMAN | FOXO3_HUMAN | kinase -> substrate | RegPhos |
| SGK1_HUMAN | BRAF_HUMAN | kinase -> substrate | HPRD; RegPhos |
| SGK1_HUMAN | IRK1_HUMAN | kinase -> substrate | RegPhos |
| SGK1_HUMAN | CREB1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| SGK1_HUMAN | MTA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| NEK6_HUMAN | SGK1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| MK07_HUMAN | SGK1_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| PDK2_HUMAN | SGK1_HUMAN | kinase -> substrate | RegPhos |
| SGK1_HUMAN | NED4L_HUMAN | kinase -> substrate | RegPhos |
| SGK1_HUMAN | M3K3_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | SGK1_HUMAN | kinase -> substrate | RegPhos |
| SGK1_HUMAN | GSK3A_HUMAN | kinase -> substrate | HPRD; RegPhos |
| SGK1_HUMAN | HD_HUMAN | kinase -> substrate | RegPhos |
| SGK1_HUMAN | HCLS1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04960 | Aldosterone-regulated sodium reabsorption |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0015459 | potassium channel regulator activity | TAS | molecular_function |
| GO:0007154 | cell communication | IEA | biological_process |
| GO:0017080 | sodium channel regulator activity | TAS | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0017081 | chloride channel regulator activity | TAS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0050790 | regulation of catalytic activity | TAS | biological_process |
| GO:0007616 | long-term memory | TAS | biological_process |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0042981 | regulation of apoptotic process | TAS | biological_process |
| GO:0032411 | positive regulation of transporter activity | TAS | biological_process |
| GO:0005246 | calcium channel regulator activity | TAS | molecular_function |
| GO:0005789 | endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0008217 | regulation of blood pressure | TAS | biological_process |
| GO:0006950 | response to stress | TAS | biological_process |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0035091 | phosphatidylinositol binding | IEA | molecular_function |
| GO:0001558 | regulation of cell growth | TAS | biological_process |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0006814 | sodium ion transport | TAS | biological_process |
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0030334 | regulation of cell migration | TAS | biological_process |
| GO:0006974 | response to DNA damage stimulus | IEA | biological_process |
| GO:0070294 | renal sodium ion absorption | TAS | biological_process |
| GO:0051090 | regulation of sequence-specific DNA binding transc | TAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0060453 | regulation of gastric acid secretion | TAS | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0042127 | regulation of cell proliferation | TAS | biological_process |