Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DPYL3_HUMAN
Description:dihydropyrimidinase-like 3 [Source:HGNC Symbol;Acc:3015]
Location:chr5 q32
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y477SPFSDyVYKRIPhosphoSitePlus
S518GTPAGsARGSPPhosphoSitePlus; HPRD
S259KVMSKsAADLIAmidohydro_1PhosphoSitePlus
Y499VPRGMyDGPVFPhosphoSitePlus
T507PVFDLtTTPKGPhosphoSitePlus
S2____MsYQGKKPhosphoSitePlus
S522GSARGsPTRPNPhosphoSitePlus; HPRD
S539HQSGFsLSGTQPhosphoSitePlus
T514TPKGGtPAGSAPhosphoSitePlus; HPRD
S551DEGVRsASKRIHPRD
S257VTKVMsKSAADAmidohydro_1PhosphoSitePlus
T509FDLTTtPKGGTPhosphoSitePlus; HPRD; SysPTM
Y431QSAAEyNIFEGPhosphoSitePlus
T524ARGSPtRPNPPPhosphoSitePlus; HPRD
S30VNDDQsFYADIPhosphoSitePlus
Y32DDQSFyADIYMPhosphoSitePlus
Y251TNCPLyVTKVMAmidohydro_1PhosphoSitePlus
S472RFIPCsPFSDYPhosphoSitePlus
T508VFDLTtTPKGGPhosphoSitePlus; HPRD
S308TSPPLsPDPTTAmidohydro_1PhosphoSitePlus
T253CPLYVtKVMSKAmidohydro_1PhosphoSitePlus
S304AAFVTsPPLSPAmidohydro_1PhosphoSitePlus

Dephosphorylation site
DPYL3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000381526A119TCOSMICHead and Neck Cancer21984974
ENSP00000381526Q340ECOSMICOvarian Cancer21720365
ENSP00000343690*685SCOSMICBreast Cancer16959974
ENSP00000381526A243SCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000343690Esophageal CancerNormal vs. CancertissueDown0.3819142970
ENSP00000343690Breast CancerNormal vs. CancertissueDown20560667

Hyperphosphorylation site
DPYL3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DYRK2_HUMANDPYL3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANDPYL3_HUMANkinase -> substrateRegPhos
GSK3B_HUMANDPYL3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
DPYL3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0007399nervous system developmentIEAbiological_process
GO:0031941filamentous actinIEAcellular_component
GO:0010976positive regulation of neuron projection developmeIEAbiological_process
GO:0051017actin filament bundle assemblyIEAbiological_process
GO:0006208pyrimidine nucleobase catabolic processIEAbiological_process
GO:0030336negative regulation of cell migrationIEAbiological_process
GO:0035374chondroitin sulfate bindingIEAmolecular_function
GO:0005615extracellular spaceIEAcellular_component
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0030426growth coneIEAcellular_component
GO:0010977negative regulation of neuron projection developmeIEAbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0030027lamellipodiumIEAcellular_component
GO:0044297cell bodyIEAcellular_component
GO:0071345cellular response to cytokine stimulusIEAbiological_process
GO:0051491positive regulation of filopodium assemblyIEAbiological_process
GO:0051764actin crosslink formationIEAbiological_process
GO:0048678response to axon injuryIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0051219phosphoprotein bindingIEAmolecular_function
GO:0016812hydrolase activity, acting on carbon-nitrogen (butIEAmolecular_function
GO:0070382exocytic vesicleISScellular_component
GO:0048666neuron developmentIEAbiological_process
GO:0051260protein homooligomerizationIEAbiological_process
GO:0016787hydrolase activityIEAmolecular_function
GO:0016810hydrolase activity, acting on carbon-nitrogen (butIEAmolecular_function


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