Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NFKB1_HUMAN
Description:nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 [Source:HGNC Symbol;Acc:7794]
Location:chr4 q24
Node attribute:TF; PPI(target); PPI(source); ubiquitination(target); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S20FHLDPsLTHTIPhosphoSitePlus
Y485EVTLTyATGTKPhosphoSitePlus
S921DELRDsDSVCDIKKaRegPhos
S900PVKTTsQAHSLGSK3BHPRD
S928DSVCDsGVETSCHUKHPRD
S337QLRRKsDLETSPhosphoSitePlus
S903TSQAHsLPLSPGSK3B(GSK3 betaRegPhos
Y409YSFPHyGFPTYPhosphoSitePlus
S923LRDSDsVCDSGIKK_betaphosphoELM
S907HSLPLsPASTRGSK-3_betaphosphoELM
S923LRDSDsVCDSGIKK_groupphosphoELM; RegPhos
T939RKLSFtESLTSPhosphoSitePlus; phosphoELM
S910PLSPAsTRQQIPhosphoSitePlus
T324KDINItKPASVPhosphoSitePlus
T911LSPAStRQQIDPhosphoSitePlus
S927DSVCDsGVETSPhosphoSitePlus; RegPhos
Y582MRNDLyQTPLHAnkPhosphoSitePlus
S923LRDSDsVCDSGIKK_alphaphosphoELM
Y59GFRFRyVCEGPRHDPhosphoSitePlus
S922DELRDsDSVCDCHUKHPRD
S903TSQAHsLPLSPGSK3BRegPhos
S908HSLPLsPASTRGSK3BHPRD
S924LRDSDsVCDSGCHUKHPRD
Y165ACIRGyNPGLLRHDPhosphoSitePlus
S942LSFTEsLTSGAHPRD
S923LRDSDsVCDSGIKKb(IKK betaRegPhos
S932SGVETsFRKLSPhosphoSitePlus
S928DSVCDsGVETSIKBKBHPRD
S894IQAASsPVKTTHPRD
S941LSFTEsLTSGAPhosphoSitePlus; phosphoELM
S927DSVCDsGVETSIKKa(IKK alphaRegPhos
S923LRDSDsVCDSGPhosphoSitePlus
S903TSQAHsLPLSPPhosphoSitePlus; phosphoELM
S927DSVCDsGVETSIKK_alphaphosphoELM
S924LRDSDsVCDSGIKBKBHPRD
T940RKLSFtESLTSHPRD
S907HSLPLsPASTRGSK3BRegPhos
S907HSLPLsPASTRPhosphoSitePlus; phosphoELM
S852NAFRLsPAPSKHPRD
S851NAFRLsPAPSKDeath; HTH_11PhosphoSitePlus
T950GASLLtLNKMPPhosphoSitePlus
S893IQAASsPVKTTPhosphoSitePlus; phosphoELM; RegPhos; SysPTM
S937SFRKLsFTESLPhosphoSitePlus
S923LRDSDsVCDSGIKKaRegPhos
S923LRDSDsVCDSGIKKbRegPhos
S337QLRRKsDLETSPKA_group RegPhos
S927DSVCDsGVETSIKK_groupphosphoELM; RegPhos
S328ITKPAsVFVQLPhosphoSitePlus
T584NDLYQtPLHLAAnkPhosphoSitePlus
S337QLRRKsDLETSPKA_groupphosphoELM; RegPhos
S933SGVETsFRKLSCHUKHPRD
S338QLRRKsDLETSPRKACAHPRD
Y240VSDAIyDSKAPRHDPhosphoSitePlus
S927DSVCDsGVETSIKKaRegPhos
S927DSVCDsGVETSIKKbRegPhos
S899PVKTTsQAHSLPhosphoSitePlus
S449EGCDKsDDKNTPhosphoSitePlus
S337QLRRKsDLETSPKACaRegPhos
T944FTESLtSGASLHPRD
S904TSQAHsLPLSPGSK3BHPRD
T413HYGFPtYGGITPhosphoSitePlus
S932SGVETsFRKLSIKKaRegPhos
S923LRDSDsVCDSGIKKa(IKK alphaRegPhos
S899PVKTTsQAHSLGSK3BRegPhos
S903TSQAHsLPLSPGSK-3_betaphosphoELM
S892VIQAAsSPVKTDeathPhosphoSitePlus
T932DSGVEtSFRKLCHUKHPRD
T931DSGVEtSFRKLIKKaRegPhos
S927DSVCDsGVETSIKK_betaphosphoELM
S907HSLPLsPASTRGSK3B(GSK3 betaRegPhos

Dephosphorylation site
NFKB1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000226574R335QCOSMICOvarian Cancer21720365
ENSP00000424790R334QTCGAOvarian Cancer21720365, 18772890
ENSP00000226574T940ICOSMICSkin Cancer21984974
ENSP00000226574P369SCOSMICSkin Cancer21984974
ENSP00000378297R335QTCGAOvarian Cancer21720365, 18772890
ENSP00000378297R334QTCGAOvarian Cancer21720365, 18772890
ENSP00000226574L611FCOSMICMelanoma21499247
ENSP00000226574Y270CCOSMICHead and Neck Cancer21798893
ENSP00000424790R335QTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000378297Uterine CancerNormal vs. Cancercell lineUp17015838902

Hyperphosphorylation site
NFKB1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANNFKB1_HUMANkinase -> substrateRegPhos
KPCA_HUMANNFKB1_HUMANkinase -> substrateHPRD
IKKB_HUMANNFKB1_HUMANkinase -> substrateHPRD; NetPath; Robert H Newman (2013)
IKKA_HUMANNFKB1_HUMANkinase -> substrateHPRD; NetPath
FBW1A_HUMANNFKB1_HUMANkinase -> substrateNetPath
GSK3B_HUMANNFKB1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
UB2D3_HUMANNFKB1_HUMANubiquitinationNetPath
NFKB1_HUMANCCL3_HUMANotherKEGG
NFKB1_HUMANIL12A_HUMANotherKEGG
NFKB1_HUMANIL6_HUMANotherKEGG
M3K8_HUMANNFKB1_HUMANotherKEGG
NFKB1_HUMANTNFA_HUMANotherKEGG
NFKB1_HUMANIL8_HUMANotherKEGG
IKBA_HUMANNFKB1_HUMANotherKEGG
NFKB1_HUMANCCL5_HUMANotherKEGG
IKKA_HUMANNFKB1_HUMANotherKEGG
NFKB1_HUMANIKBA_HUMANotherKEGG
NFKB1_HUMANCCL4_HUMANotherKEGG
M3K14_HUMANNFKB1_HUMANotherKEGG
NFKB1_HUMANIL1B_HUMANotherKEGG
NOD1_HUMANNFKB1_HUMANotherKEGG
NFKB1_HUMANIL8_HUMANTF -> target geneKEGG
NFKB1_HUMANCCL5_HUMANTF -> target geneKEGG
NFKB1_HUMANGROA_HUMANTF -> target geneKEGG
NFKB1_HUMANSOCS3_HUMANTF -> target geneKEGG
ELF1_HUMANNFKB1_HUMANTF -> target geneTRANSFAC
SUH_HUMANNFKB1_HUMANTF -> target geneTRANSFAC
ETS1_HUMANNFKB1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05222Small cell lung cancer
hsa05152Tuberculosis
hsa05162Measles
hsa05160Hepatitis C
hsa05140Leishmaniasis
hsa04622RIG-I-like receptor signaling pathway
hsa05169Epstein-Barr virus infection
hsa05203Viral carcinogenesis
hsa05131Shigellosis
hsa04623Cytosolic DNA-sensing pathway
hsa04062Chemokine signaling pathway
hsa04210Apoptosis
hsa04380Osteoclast differentiation
hsa05164Influenza A
hsa04662B cell receptor signaling pathway
hsa05030Cocaine addiction
hsa05168Herpes simplex infection
hsa05215Prostate cancer
hsa05221Acute myeloid leukemia
hsa04920Adipocytokine signaling pathway
hsa05132Salmonella infection
hsa04722Neurotrophin signaling pathway
hsa05202Transcriptional misregulation in cancer
hsa05142Chagas disease (American trypanosomiasis)
hsa05220Chronic myeloid leukemia
hsa04620Toll-like receptor signaling pathway
hsa05212Pancreatic cancer
hsa04621NOD-like receptor signaling pathway
hsa05146Amoebiasis
hsa05120Epithelial cell signaling in Helicobacter pylori i
hsa04064NF-kappa B signaling pathway
hsa04010MAPK signaling pathway
hsa05145Toxoplasmosis
hsa05200Pathways in cancer
hsa05166HTLV-I infection
hsa04660T cell receptor signaling pathway
hsa05133Pertussis
hsa05134Legionellosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000975regulatory region DNA bindingIDAmolecular_function
GO:0006979response to oxidative stressIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0010957negative regulation of vitamin D biosynthetic procICbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0034130toll-like receptor 1 signaling pathwayTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0032375negative regulation of cholesterol transportICbiological_process
GO:0005634nucleusIEAcellular_component
GO:0002224toll-like receptor signaling pathwayTASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0009617response to bacteriumIEAbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:1900127positive regulation of hyaluronan biosynthetic proIDAbiological_process
GO:0031072heat shock protein bindingIEAmolecular_function
GO:0031293membrane protein intracellular domain proteolysisTASbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0006915apoptotic processIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0007165signal transductionIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0001071nucleic acid binding transcription factor activityIDAmolecular_function
GO:0033256I-kappaB/NF-kappaB complexTAScellular_component
GO:0001818negative regulation of cytokine productionIEAbiological_process
GO:0010884positive regulation of lipid storageICbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0032481positive regulation of type I interferon productioTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0000122negative regulation of transcription from RNA polyICbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0003690double-stranded DNA bindingIEAmolecular_function
GO:0005739mitochondrionIDAcellular_component
GO:0045087innate immune responseTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0071347cellular response to interleukin-1IEPbiological_process
GO:0046688response to copper ionIEAbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwTASbiological_process
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0000976transcription regulatory region sequence-specific IDAmolecular_function
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0032269negative regulation of cellular protein metabolic ICbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0010956negative regulation of calcidiol 1-monooxygenase aIDAbiological_process
GO:0034134toll-like receptor 2 signaling pathwayTASbiological_process
GO:0043234protein complexIEAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0010744positive regulation of macrophage derived foam celICbiological_process
GO:0090263positive regulation of canonical Wnt receptor signIMPbiological_process
GO:0045083negative regulation of interleukin-12 biosyntheticIEAbiological_process