Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NOTC2_HUMAN
Description:notch 2 [Source:HGNC Symbol;Acc:7882]
Location:chr1 p11.2
Node attribute:substrate; receptor; glycosylation(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1804IRRTPsLALTPPhosphoSitePlus; HPRD; phosphoELM
Y2373TILPAyHPFPAPhosphoSitePlus
T2068DEYNVtPSPPGGSK3BHPRD; RegPhos
S2134SRRKKsLSEKVPhosphoSitePlus
T2074PSPPGtVLTSAphosphoELM
T2077PGTVLtSALSPHPRD
S1854EDAEDsSANIIHPRD
S1722LRRDAsNHKRRPhosphoSitePlus
S1778DEALLsEEDDPPhosphoSitePlus; HPRD; phosphoELM
Y2023AREGSyEAAKIHPRD
S1708KRKHGsLWLPE7TMR-DISM_7TMPhosphoSitePlus
S1841SLRGGsSDLSDHPRD; phosphoELM; RegPhos
T436GKCVNtDGAFHEGF_CAPhosphoSitePlus
S1855DAEDSsANIITHPRD
Y2470NNMQVyA____PhosphoSitePlus
S2070YNVTPsPPGTVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T436GKCVNtDGAFHHPRD
S1842LRGGSsDLSDEHPRD; RegPhos
S2093NRSFLsLKHTPGSK3BHPRD; RegPhos
S2129KDAKGsRRKKSPhosphoSitePlus
T1808PSLALtPPQAEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S1845GSSDLsDEDEDPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S2078GTVLTsALSPVHPRD; RegPhos
T2296GKHITtPREPLPhosphoSitePlus; HPRD; phosphoELM
T2295EGKHItTPREPHPRD
S2081LTSALsPVICGPhosphoSitePlus; HPRD; phosphoELM
T1716LPEGFtLRRDAPhosphoSitePlus; HPRD; phosphoELM
T1802ADIRRtPSLALPhosphoSitePlus; HPRD; phosphoELM
S1670SVVSEsLTPERNODP; 7TMR-DISM_7TMPhosphoSitePlus
S2136RKKSLsEKVQLPhosphoSitePlus
T2097LSLKHtPMGKKPhosphoSitePlus; HPRD; phosphoELM
T2074PSPPGtVLTSAGSK3BHPRD; RegPhos
S2070YNVTPsPPGTVGSK3BHPRD; RegPhos

Dephosphorylation site
NOTC2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000256646G488DCOSMICSkin Cancer21984974
ENSP00000256646D2125NBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000256646E297KCOSMICSkin Cancer21984974
ENSP00000256646C19WCOSMICCentral Nervous System Neoplasms21817013
ENSP00000256646R1931HCOSMICOvarian Cancer21720365
ENSP00000256646P2289fs*6COSMICLymphoma19445024
ENSP00000256646P2343SCOSMICSkin Cancer22006338
ENSP00000256646H1638YCOSMICLymphoma18508802
ENSP00000256646P224LCOSMICSkin Cancer21984974
ENSP00000256646Y790CCOSMICOvarian Cancer21720365
ENSP00000256646S2394FCOSMICLung Cancer20668451
ENSP00000256646Q1584*COSMICLung Cancer
ENSP00000256646P1913SCOSMICSkin Cancer22006338
ENSP00000256646E850*COSMICHead and Neck Cancer21798893
ENSP00000256646Q1616*COSMICSkin Cancer21984974
ENSP00000256646N46SCOSMICSkin Cancer22006338
ENSP00000256646M1879ICOSMICLung Cancer20668451
ENSP00000256646Q1634*COSMICSkin Cancer21984974
ENSP00000256646Q1392*COSMICLung Cancer22006338
ENSP00000256646Y857CCOSMICHead and Neck Cancer21798893
ENSP00000256646R1630LCOSMICLung Cancer20668451
ENSP00000256646C616FCOSMICSkin Cancer22006338
ENSP00000256646S2222IDing2008, COSMICLung Cancer18948947
ENSP00000256646D1733YCOSMICLung Cancer22006338
ENSP00000256646R2105QCOSMICHead and Neck Cancer21798893
ENSP00000256646C861YCOSMICSkin Cancer22006338
ENSP00000256646R2453QCOSMICLymphoma19445024
ENSP00000256646H1512YCOSMICMelanoma21499247
ENSP00000256646S1888*COSMICLung Cancer
ENSP00000256646G1751DCOSMICSkin Cancer22006338
ENSP00000256646A1806TCOSMICLung Cancer20668451
ENSP00000256646S1836FCOSMICSkin Cancer21984974
ENSP00000256646E38KCOSMICSkin Cancer22006338
ENSP00000256646R1048CCOSMICRenal Cancer20054297
ENSP00000256646D1451NCOSMICSkin Cancer22006338
ENSP00000256646R2400*COSMICLymphoma19445024
ENSP00000256646V721LCOSMICHead and Neck Cancer21798893
ENSP00000256646S2388LCOSMICLung Cancer20668451
ENSP00000256646A1340SCOSMICOvarian Cancer21720365
ENSP00000256646T2278ICOSMICSkin Cancer21984974
ENSP00000256646R1838*COSMICSkin Cancer21984974
ENSP00000256646G313CCOSMICSkin Cancer21984974
ENSP00000256646K1514RBIOMARTBreast Cancer21930507, 21930502
ENSP00000256646C433YCOSMICSkin Cancer22006338
ENSP00000256646W330*COSMICSkin Cancer21984974
ENSP00000256646G601CCOSMICCentral Nervous System Neoplasms18772396
ENSP00000256646K758RCOSMICProstate Cancer20668451
ENSP00000256646R452CCOSMICSkin Cancer21984974
ENSP00000256646V2075MCOSMICRenal Cancer20054297
ENSP00000256646Q2341*COSMICLymphoma18508802

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000256646Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
NOTC2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JAG1_HUMANNOTC2_HUMANligand -> receptorHPMR
ZAGL2_HUMANNOTC2_HUMANkinase -> substrateRegPhos
GSK3B_HUMANNOTC2_HUMANkinase -> substrateRegPhos; NetPath
LFNG_HUMANNOTC2_HUMANglycosylationNetPath
MFNG_HUMANNOTC2_HUMANglycosylationNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04320Dorso-ventral axis formation
hsa04330Notch signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009887organ morphogenesisIEPbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0046579positive regulation of Ras protein signal transducIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030154cell differentiationIEAbiological_process
GO:0006917induction of apoptosisTASbiological_process
GO:0007050cell cycle arrestIDAbiological_process
GO:0003184pulmonary valve morphogenesisIMPbiological_process
GO:0061314Notch signaling involved in heart developmentICbiological_process
GO:0006355regulation of transcription, DNA-dependentTASbiological_process
GO:0005789endoplasmic reticulum membraneTAScellular_component
GO:0001890placenta developmentIEAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0016049cell growthIDAbiological_process
GO:0000139Golgi membraneTAScellular_component
GO:0010467gene expressionTASbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0030097hemopoiesisTASbiological_process
GO:0002011morphogenesis of an epithelial sheetIEAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0043066negative regulation of apoptotic processTASbiological_process
GO:0060674placenta blood vessel developmentIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0050793regulation of developmental processIEAbiological_process
GO:0072602interleukin-4 secretionIEAbiological_process
GO:0060413atrial septum morphogenesisIMPbiological_process
GO:0007220Notch receptor processingTASbiological_process
GO:0004872receptor activityNASmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0007368determination of left/right symmetryIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0007399nervous system developmentNASbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0005509calcium ion bindingIEAmolecular_function
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0002437inflammatory response to antigenic stimulusIEAbiological_process
GO:0019827stem cell maintenanceTASbiological_process
GO:0007275multicellular organismal developmentNASbiological_process
GO:0006959humoral immune responseIEAbiological_process
GO:0001709cell fate determinationTASbiological_process
GO:0046849bone remodelingIMPbiological_process


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