Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACLY_HUMAN
Description:ATP citrate lyase [Source:HGNC Symbol;Acc:115]
Location:chr17 q21.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S481QDSVPsPRSLQPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y247FGREAyPEEAYPhosphoSitePlus
S663AYVSRsGGMSNLigase_CoAPhosphoSitePlus
Y364RAIRDyQGPLKPhosphoSitePlus
H760EVQFGhAGACALigase_CoAPhosphoSitePlus
S979GHRVKsINNPDPhosphoSitePlus
T677NIISRtTDGVYLigase_CoAPhosphoSitePlus
T445NASGStSTPAPPhosphoSitePlus; HPRD
S459ASFSEsRADEVPhosphoSitePlus; HPRD; phosphoELM
S1090LPEHMHPRD
S455PSRTAsFSESRPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y384RGGPNyQEGLRPhosphoSitePlus
S451STPAPsRTASFPhosphoSitePlus
Y682TTDGVyEGVAIHPRD; phosphoELM; RegPhos
S451STPAPsRTASFGSK_groupRegPhos
S455PSRTAsFSESRPRKACAHPRD; SysPTM
Y1073GFIGHyLDQKRPhosphoSitePlus
S574LINFAsLRSAYCoA_bindingPhosphoSitePlus
Y588METMNyAQIRTCoA_bindingPhosphoSitePlus
T930TSGLLtIGDRFPhosphoSitePlus
S442FLLNAsGSTSTPhosphoSitePlus; HPRD
S457RTASFsESRADPhosphoSitePlus; SysPTM
T447SGSTStPAPSRGSK_groupRegPhos
S1100LPEHMsM____PhosphoSitePlus; SysPTM
S260DLDAKsGASLKPhosphoSitePlus
S444LNASGsTSTPAPhosphoSitePlus
T453PAPSRtASFSEPhosphoSitePlus; HPRD; phosphoELM
T639FKIGNtGGMLDPhosphoSitePlus
T447SGSTStPAPSRGSK3BHPRD; RegPhos
S451STPAPsRTASFGSK3BHPRD; RegPhos
S455PSRTAsFSESRPKA_groupphosphoELM; RegPhos; SysPTM
Y531VAAMVyPFTGDCoA_bindingPhosphoSitePlus
S451STPAPsRTASFGSK-3_groupphosphoELM
S484VPSPRsLQGKSHPRD
S478AMPQDsVPSPRPhosphoSitePlus; HPRD; phosphoELM
S455PSRTAsFSESRPKACaRegPhos; SysPTM
Y317SEQQTyDYAKTPhosphoSitePlus
Y1084LKQGLyRHPWDPhosphoSitePlus
T447SGSTStPAPSRGSK-3_groupphosphoELM
T447SGSTStPAPSRPhosphoSitePlus
Y672TTDGVyEGVAIHPRD
Y652LASKLyRPGSVLigase_CoAPhosphoSitePlus
Y682TTDGVyEGVAILigase_CoAPhosphoSitePlus
Y131TREGDyVLFHHPhosphoSitePlus; HPRD; RegPhos
S446ASGSTsTPAPSPhosphoSitePlus
S1100LPEHMHPRD; phosphoELM; SysPTM
S839IRKPAsFMTSIPhosphoSitePlus

Dephosphorylation site
ACLY_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000253792M1LCOSMICOvarian Cancer21720365
ENSP00000253792S525ACOSMICCentral Nervous System Neoplasms18772396
ENSP00000253792A1048GCOSMICOvarian Cancer21720365
ENSP00000253792L43FCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000253792Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.4318646787
ENSP00000253792Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.4818646787
ENSP00000253792Gastric CancerMetastasiscell lineDown0.6917022644
ENSP00000253792Hepatocellular CarcinomaMetastasiscell lineUp2.419016532
ENSP00000253792Gastric CancerMetastasiscell lineDown0.6917022644
ENSP00000253792Breast CancerNormal vs. CancertissueUp0.6420739354
ENSP00000253792Breast CancerNormal vs. CancertissueUp0.6420739354
ENSP00000253792Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
ACLY_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GSK3B_HUMANACLY_HUMANkinase -> substrateRegPhos
KPCA_HUMANACLY_HUMANkinase -> substrateHPRD
ZAGL2_HUMANACLY_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa01100Metabolic pathways
hsa00020Citrate cycle (TCA cycle)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003824catalytic activityIEAmolecular_function
GO:0006112energy reserve metabolic processTASbiological_process
GO:0046912transferase activity, transferring acyl groups, acIEAmolecular_function
GO:0006101citrate metabolic processTASbiological_process
GO:0031325positive regulation of cellular metabolic processTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0009346citrate lyase complexTAScellular_component
GO:0019432triglyceride biosynthetic processTASbiological_process
GO:0004775succinate-CoA ligase (ADP-forming) activityIEAmolecular_function
GO:0003878ATP citrate synthase activityTASmolecular_function
GO:0044262cellular carbohydrate metabolic processIEAbiological_process
GO:0015936coenzyme A metabolic processTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0005634nucleusIDAcellular_component
GO:0048037cofactor bindingIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0006200ATP catabolic processTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0044255cellular lipid metabolic processTASbiological_process
GO:0008152metabolic processIEAbiological_process
GO:0035338long-chain fatty-acyl-CoA biosynthetic processTASbiological_process
GO:0005829cytosolTAScellular_component


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