| UniProt/SwissProt ID: | CDX2_HUMAN |
| Description: | caudal type homeobox 2 [Source:HGNC Symbol;Acc:1806] |
| Location: | chr13 q12.2 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T310 | GVLNPtVTQ__ | PhosphoSitePlus | |
| S295 | ASVPGsVPGVL | GSK3B | HPRD |
| S295 | ASVPGsVPGVL | MAPK14 | HPRD |
| S226 | ATLGLsERQVK | Homeobox | PhosphoSitePlus |
| S291 | SSLQAsVPGSV | MAPK14 | HPRD |
| S295 | ASVPGsVPGVL | CDK2 | HPRD |
| S283 | VPEPLsPVSSL | CDK2 | HPRD; RegPhos |
| S277 | PGPLRsVPEPL | PhosphoSitePlus | |
| S283 | VPEPLsPVSSL | PhosphoSitePlus | |
| S287 | LSPVSsLQASV | MAPK14 | HPRD |
| S291 | SSLQAsVSGSV | GSK3B | RegPhos |
| S291 | SSLQAsVSGSV | p38a | RegPhos |
| S283 | VPEPLsPVSSL | GSK3B | HPRD; RegPhos |
| S291 | SSLQAsVSGSV | CDK2 | RegPhos |
| S60 | LDSAQsPGPSW | HPRD; phosphoELM; RegPhos | |
| S291 | SSLQAsVPGSV | GSK3B | HPRD |
| S295 | ASVSGsVPGVL | p38a | RegPhos |
| S283 | VPEPLsPVSSL | p38a | RegPhos |
| S287 | LSPVSsLQASV | GSK3B | HPRD; RegPhos |
| S291 | SSLQAsVPGSV | CDK2 | HPRD |
| S287 | LSPVSsLQASV | p38a | RegPhos |
| S283 | VPEPLsPVSSL | MAPK14 | HPRD |
| S295 | ASVSGsVPGVL | CDK2 | RegPhos |
| S287 | LSPVSsLQASV | CDK2 | HPRD; RegPhos |
| S295 | ASVSGsVPGVL | GSK3B | RegPhos |
| T312 | LNPTVtQ____ | PhosphoSitePlus | |
| Dephosphorylation site |
| CDX2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| CDX2_HUMAN do not have mutation site. |
| Differential expressed protein |
| CDX2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CDX2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK2_HUMAN | CDX2_HUMAN | kinase -> substrate | RegPhos |
| MK14_HUMAN | CDX2_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | CDX2_HUMAN | kinase -> substrate | RegPhos |
| GSK3B_HUMAN | CDX2_HUMAN | kinase -> substrate | RegPhos |
| CDX2_HUMAN | CLD2_HUMAN | TF -> target gene | TRANSFAC |
| CDX2_HUMAN | MOK_HUMAN | TF -> target gene | TRANSFAC |
| CDX2_HUMAN | MUC2_HUMAN | TF -> target gene | TRANSFAC |
| CDX2_HUMAN | BCL2_HUMAN | TF -> target gene | TRANSFAC |
| CDX2_HUMAN | STAR_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| CDX2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0060711 | labyrinthine layer development | IEA | biological_process |
| GO:0006357 | regulation of transcription from RNA polymerase II | IEA | biological_process |
| GO:0009887 | organ morphogenesis | TAS | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0000976 | transcription regulatory region sequence-specific | IEA | molecular_function |
| GO:0003714 | transcription corepressor activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0000794 | condensed nuclear chromosome | IEA | cellular_component |
| GO:0001890 | placenta development | IEA | biological_process |
| GO:0008333 | endosome to lysosome transport | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0035019 | somatic stem cell maintenance | IEA | biological_process |
| GO:0045597 | positive regulation of cell differentiation | IEA | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0017053 | transcriptional repressor complex | IEA | cellular_component |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0001824 | blastocyst development | IEA | biological_process |
| GO:0007275 | multicellular organismal development | IEA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0009952 | anterior/posterior pattern specification | IEA | biological_process |
| GO:0001829 | trophectodermal cell differentiation | IEA | biological_process |
| GO:0045197 | establishment or maintenance of epithelial cell ap | IEA | biological_process |
| GO:0043234 | protein complex | IEA | cellular_component |
| GO:0007389 | pattern specification process | IEA | biological_process |
| GO:0001568 | blood vessel development | IEA | biological_process |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | biological_process |