Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NACA_HUMAN
Description:nascent polypeptide-associated complex alpha subunit [Source:HGNC Symbol;Acc:7629]
Location:chr12 q13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S43LEEQDsTQATTILK1RegPhos
T92QVTGVtRVTIRRegPhos
S166TVQEEsEEEEVphosphoELM; RegPhos; SysPTM
T159QENTQtPTVQEGSK3B(GSK3 betaRegPhos
T161NTQTPtVQEESRegPhos; SysPTM
S43LEEQDsTQATTILKphosphoELM; RegPhos
S186IELVMsQANVSRegPhos
T159QENTQtPTVQEGSK-3_betaphosphoELM
S191DIELVMSQANVSRSysPTM 2.0
T174VQGEAVSNIQENTQTPTVQEESEEEEVDETGVEVKSysPTM 2.0

Dephosphorylation site
NACA_HUMAN do not have dephosphorylation site.

Mutation site
NACA_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000377469Breast CancerMetastasiscell lineDown0.3818582095
ENSP00000377469Breast CancerMetastasiscell lineUp218582095
ENSP00000377469Breast CancerMetastasiscell lineUp2.418582095
ENSP00000377469Breast CancerTreatment (tamoxifen-sensitive vs. tamoxifen-resistant)tissueDown0.4619329653
ENSP00000377469Oral CancerNormal vs. CancertissueUp4.419691830
ENSP00000377469acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1717655343
ENSP00000377469acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.1817655343
ENSP00000377469acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343

Hyperphosphorylation site
NACA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ILK_HUMANNACA_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANNACA_HUMANkinase -> substrateRegPhos
GSK3B_HUMANNACA_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
NACA_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006412translationTASbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0003231cardiac ventricle developmentISSbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:1901227negative regulation of transcription from RNA polyISSbiological_process
GO:0010664negative regulation of striated muscle cell apoptoISSbiological_process
GO:0048633positive regulation of skeletal muscle tissue growISSbiological_process
GO:0043403skeletal muscle tissue regenerationISSbiological_process
GO:0003713transcription coactivator activityISSmolecular_function
GO:0015031protein transportIEAbiological_process
GO:0061384heart trabecula morphogenesisISSbiological_process
GO:1901228positive regulation of transcription from RNA polyISSbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0048742regulation of skeletal muscle fiber developmentISSbiological_process
GO:0017025TBP-class protein bindingISSmolecular_function
GO:0005634nucleusISScellular_component
GO:0005737cytoplasmISScellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:2000138positive regulation of cell proliferation involvedISSbiological_process
GO:0005854nascent polypeptide-associated complexTAScellular_component


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