Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SGK3_HUMAN
Description:Serine/threonine-protein kinase Sgk3 [Source:UniProtKB/Swiss-Prot;Acc:Q96BR1]
Location:chr8 q13.1
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T320SDTTTtFCGTPPDK-1phosphoELM
T320SDTTTtFCGTPPDPK1HPRD
S454AFVGFsYAPPSPDPK1HPRD
S315EGIAIsDTTTTPkinasePhosphoSitePlus
Y188LDGKFyAVKVLPkinasePhosphoSitePlus
T318AISDTtTTFCGPkinasePhosphoSitePlus
T320SDTTTtFCGTPPkinasePhosphoSitePlus
T324TTFCGtPEYLAPkinasePhosphoSitePlus
S486AFVGFsYAPPSphosphoELM; RegPhos
S486AFVGFsYAPPSPDK1RegPhos
S486AFVGFsYAPPSPDPK1HPRD
T320SDTTTtFCGTPPDK1RegPhos
S486AFVGFsYAPPSPkinase_CPhosphoSitePlus

Dephosphorylation site
SGK3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000430463G169ATCGAOvarian Cancer21720365, 18772890
ENSP00000379842G169ATCGAOvarian Cancer21720365, 18772890
ENSP00000262211G169ATCGAOvarian Cancer21720365, 18772890
ENSP00000262211A92VSjoblom2006, HPIBreast Cancer16959974
ENSP00000430256G169ATCGAOvarian Cancer21720365, 18772890
ENSP00000331816G169ATCGAOvarian Cancer21720365, 18772890
ENSP00000429022G169ATCGAOvarian Cancer21720365, 18772890
ENSP00000379842A92VSjoblom2006, HPI, BIOMARTBreast Cancer16959974, 21930507, 21930502

Differential expressed protein
SGK3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SGK3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SGK3_HUMANFIP1_HUMANkinase -> substrateRobert H Newman (2013)
SGK3_HUMANGSK3A_HUMANkinase -> substrateHPRD; RegPhos
PDPK1_HUMANSGK3_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANSGK3_HUMANkinase -> substrateRegPhos
SGK3_HUMANGSK3B_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
SGK3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0017080sodium channel regulator activityTASmolecular_function
GO:0016023cytoplasmic membrane-bounded vesicleIEAcellular_component
GO:0035091phosphatidylinositol bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0017081chloride channel regulator activityTASmolecular_function
GO:0005246calcium channel regulator activityTASmolecular_function
GO:0042127regulation of cell proliferationTASbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0015459potassium channel regulator activityTASmolecular_function
GO:0001558regulation of cell growthTASbiological_process
GO:0030334regulation of cell migrationTASbiological_process
GO:0006950response to stressTASbiological_process
GO:0005769early endosomeIEAcellular_component
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0055037recycling endosomeIEAcellular_component
GO:0004672protein kinase activityTASmolecular_function
GO:0006468protein phosphorylationTASbiological_process
GO:0051090regulation of sequence-specific DNA binding transcTASbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0007154cell communicationIEAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function


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