| UniProt/SwissProt ID: | SGK3_HUMAN |
| Description: | Serine/threonine-protein kinase Sgk3 [Source:UniProtKB/Swiss-Prot;Acc:Q96BR1] |
| Location: | chr8 q13.1 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T320 | SDTTTtFCGTP | PDK-1 | phosphoELM |
| T320 | SDTTTtFCGTP | PDPK1 | HPRD |
| S454 | AFVGFsYAPPS | PDPK1 | HPRD |
| S315 | EGIAIsDTTTT | Pkinase | PhosphoSitePlus |
| Y188 | LDGKFyAVKVL | Pkinase | PhosphoSitePlus |
| T318 | AISDTtTTFCG | Pkinase | PhosphoSitePlus |
| T320 | SDTTTtFCGTP | Pkinase | PhosphoSitePlus |
| T324 | TTFCGtPEYLA | Pkinase | PhosphoSitePlus |
| S486 | AFVGFsYAPPS | phosphoELM; RegPhos | |
| S486 | AFVGFsYAPPS | PDK1 | RegPhos |
| S486 | AFVGFsYAPPS | PDPK1 | HPRD |
| T320 | SDTTTtFCGTP | PDK1 | RegPhos |
| S486 | AFVGFsYAPPS | Pkinase_C | PhosphoSitePlus |
| Dephosphorylation site |
| SGK3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000430463 | G169A | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000379842 | G169A | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000262211 | G169A | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000262211 | A92V | Sjoblom2006, HPI | Breast Cancer | 16959974 | ENSP00000430256 | G169A | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000331816 | G169A | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000429022 | G169A | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000379842 | A92V | Sjoblom2006, HPI, BIOMART | Breast Cancer | 16959974, 21930507, 21930502 |
| Differential expressed protein |
| SGK3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SGK3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SGK3_HUMAN | FIP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SGK3_HUMAN | GSK3A_HUMAN | kinase -> substrate | HPRD; RegPhos |
| PDPK1_HUMAN | SGK3_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | SGK3_HUMAN | kinase -> substrate | RegPhos |
| SGK3_HUMAN | GSK3B_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| SGK3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0017080 | sodium channel regulator activity | TAS | molecular_function |
| GO:0016023 | cytoplasmic membrane-bounded vesicle | IEA | cellular_component |
| GO:0035091 | phosphatidylinositol binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0017081 | chloride channel regulator activity | TAS | molecular_function |
| GO:0005246 | calcium channel regulator activity | TAS | molecular_function |
| GO:0042127 | regulation of cell proliferation | TAS | biological_process |
| GO:0043066 | negative regulation of apoptotic process | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0015459 | potassium channel regulator activity | TAS | molecular_function |
| GO:0001558 | regulation of cell growth | TAS | biological_process |
| GO:0030334 | regulation of cell migration | TAS | biological_process |
| GO:0006950 | response to stress | TAS | biological_process |
| GO:0005769 | early endosome | IEA | cellular_component |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0055037 | recycling endosome | IEA | cellular_component |
| GO:0004672 | protein kinase activity | TAS | molecular_function |
| GO:0006468 | protein phosphorylation | TAS | biological_process |
| GO:0051090 | regulation of sequence-specific DNA binding transc | TAS | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0007154 | cell communication | IEA | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |