Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MK67I_HUMAN
Description:MKI67 (FHA domain) interacting nucleolar phosphoprotein [Source:HGNC Symbol;Acc:17838]
Location:chr2 q14.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S291KRRRSsNQ___PhosphoSitePlus
S230EKTVDsQGPTPhNIFK_bindingPhosphoSitePlus
S204TNRQTsTKGQVPhosphoSitePlus
Y88GNSKGyAFVEFRRM_1PhosphoSitePlus
T156RNRTLtQKLRMPhosphoSitePlus
T234DSQGPtPVCTPHPRD; phosphoELM; RegPhos
T199ESISKtNRQTSPhosphoSitePlus
T240PVCTPtFLERRHPRD; phosphoELM; RegPhos
S230EKTVDsQGPTPGSK3B(GSK3 betaRegPhos
Y183KKGIDyDFPSLPhosphoSitePlus
S230EKTVDsQGPTPGSK3A(GSK3 alphaRegPhos
T227DTPEKtVDSQGHPRD; phosphoELM
T234DSQGPtPVCTPGSK3A(GSK3 alphaRegPhos
T277EEIQEtQTPTHPhosphoSitePlus
T238PTPVCtPTFLEHPRD; phosphoELM; RegPhos
S290KKRRRsSNQ__PhosphoSitePlus
S230EKTVDsQGPTPGSK-3_betaphosphoELM
S247LERRKsQVAELhNIFK_bindingPhosphoSitePlus; SysPTM
T238PTPVCtPTFLEhNIFK_bindingPhosphoSitePlus
T234DSQGPtPVCTPhNIFK_bindingPhosphoSitePlus
T220KKVSGtLDTPEPhosphoSitePlus; HPRD; phosphoELM
T234DSQGPtPVCTPGSK3B(GSK3 betaRegPhos
S218KKKKVsGTLDTPhosphoSitePlus; HPRD; phosphoELM
T154YNRNRtLTQKLPhosphoSitePlus
T223SGTLDtPEKTVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S230EKTVDsQGPTPGSK-3_alphaphosphoELM
T234DSQGPtPVCTPGSK-3_betaphosphoELM
S247LERRKsQVAELHPRD; phosphoELM; RegPhos; SysPTM
T234DSQGPtPVCTPGSK-3_alphaphosphoELM
T240PVCTPtFLERRhNIFK_bindingPhosphoSitePlus
S230EKTVDsQGPTPHPRD; phosphoELM; RegPhos
T279IQETQtPTHSRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T227DTPEKtVDSQGhNIFK_bindingPhosphoSitePlus

Dephosphorylation site
MK67I_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000285814R153QBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
MK67I_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MK67I_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GSK3B_HUMANMK67I_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANMK67I_HUMANkinase -> substrateRegPhos
GSK3A_HUMANMK67I_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
MK67I_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0010923negative regulation of phosphatase activityIDAbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0009303rRNA transcriptionNASbiological_process
GO:0003723RNA bindingIDAmolecular_function
GO:0005730nucleolusIDAcellular_component
GO:0000166nucleotide bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006461protein complex assemblyNASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005654nucleoplasmIDAcellular_component
GO:0000794condensed nuclear chromosomeIDAcellular_component
GO:0016072rRNA metabolic processNASbiological_process


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