Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LRP6_HUMAN
Description:low density lipoprotein receptor-related protein 6 [Source:HGNC Symbol;Acc:6698]
Location:chr12 p13.2
Node attribute:substrate; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1496PATERsHYTMEPhosphoSitePlus
Y1541VCDSDyAPSRRPhosphoSitePlus
Y1480STKGTyFPAILPhosphoSitePlus
S1510SSNSPsTHRSYPhosphoSitePlus
Y1498TERSHyTMEFGPhosphoSitePlus
Y1515STHRSySYRPYPhosphoSitePlus
T1572VPPPPtPRSQYGSK3BHPRD
S171AGMDGsSRFIILdl_recept_bPhosphoSitePlus
T1476SSSSStKGTYFPhosphoSitePlus
S209NFIHKsNLDGTLdl_recept_bPhosphoSitePlus
T1499ERSHYtMEFGYPhosphoSitePlus
S1508GYSSNsPSTHRPhosphoSitePlus
S1612SPCTDsS____PhosphoSitePlus
S1420VHGPAsVPLGYPhosphoSitePlus
S1455SIMGGsSGPPYPhosphoSitePlus
S172GMDGSsRFIIILdl_recept_bPhosphoSitePlus
T1001GSQGFtVVVSSPhosphoSitePlus
S1516THRSYsYRPYSPhosphoSitePlus
Y1584SAEENyESCPPPhosphoSitePlus
Y1577TPRSQyLSAEEPhosphoSitePlus
Y1504TMEFGySSNSPPhosphoSitePlus
S1506EFGYSsNSPSTPhosphoSitePlus
T1493PPSPAtERSHYPhosphoSitePlus
S1590ESCPPsPYTERPhosphoSitePlus
T1548PSRRMtSVATAPhosphoSitePlus
S1607YPPPPsPCTDGSK3BHPRD
Y1517HRSYSyRPYSYPhosphoSitePlus
Y1522YRPYSyRHFAPPhosphoSitePlus
T1572VPPPPtPRSQYPhosphoSitePlus
S127SNLDGsLRKVLHPRD
S1474SSSSSsSTKGTPhosphoSitePlus
S1490LNPPPsPATERGSK3BHPRD
S1613PCTDSs_____PhosphoSitePlus
S1575PPTPRsQYLSAPhosphoSitePlus
S1431VPHPSsLSGSLPhosphoSitePlus
S1490LNPPPsPATERPhosphoSitePlus
T1479SSTKGtYFPAIPhosphoSitePlus
S1544SDYAPsRRMTSPhosphoSitePlus
Y1562TSDLNyDSEPVPhosphoSitePlus
T214SNLDGtNRQAVLdl_recept_bPhosphoSitePlus
S1475SSSSSsTKGTYPhosphoSitePlus
S1607YPPPPsPCTDSPhosphoSitePlus
S122NRIEVsNLDGSHPRD
Y1520YSYRPySYRHFPhosphoSitePlus

Dephosphorylation site
LRP6_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000261349V881LCOSMICCentral Nervous System Neoplasms21163964
ENSP00000261349I271LCOSMICHead and Neck Cancer21798893
ENSP00000261349R644*COSMICLung Cancer20668451
ENSP00000261349G999SCOSMICMelanoma
ENSP00000261349P369SCOSMICSkin Cancer21984974
ENSP00000261349P225RCOSMICRenal Cancer20054297
ENSP00000261349G1503*COSMICHead and Neck Cancer21798893
ENSP00000261349A26TCOSMICLung Cancer20668451
ENSP00000261349R341HCOSMICLung Cancer20668451
ENSP00000261349I342VCOSMICHead and Neck Cancer21798893
ENSP00000261349T867ICOSMICMelanoma21499247
ENSP00000261349I568TCOSMICOvarian Cancer20668451
ENSP00000261349D983NCOSMICHead and Neck Cancer21798893
ENSP00000261349Q998RCOSMICLung Cancer
ENSP00000261349S1613YCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000261349Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
LRP6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DKK2_HUMANLRP6_HUMANligand -> receptorHPMR
RSPO1_HUMANLRP6_HUMANligand -> receptorHPMR
SOST_HUMANLRP6_HUMANligand -> receptorHPMR
DKK1_HUMANLRP6_HUMANligand -> receptorHPMR
CTGF_HUMANLRP6_HUMANligand -> receptorHPMR
GSK3B_HUMANLRP6_HUMANkinase -> substrateHPRD
GSK3A_HUMANLRP6_HUMANkinase -> substrateNetPath
DKK1_HUMANLRP6_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04310Wnt signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031410cytoplasmic vesicleIDAcellular_component
GO:0048705skeletal system morphogenesisIEAbiological_process
GO:0014029neural crest formationIDAbiological_process
GO:2000051negative regulation of non-canonical Wnt receptor IEAbiological_process
GO:0001702gastrulation with mouth forming secondIBAbiological_process
GO:0051593response to folic acidIEAbiological_process
GO:2000055positive regulation of Wnt receptor signaling pathIDAbiological_process
GO:0046849bone remodelingIEAbiological_process
GO:0016055Wnt receptor signaling pathwayIMPbiological_process
GO:0090118receptor-mediated endocytosis of low-density lipopIEAbiological_process
GO:0090244Wnt receptor signaling pathway involved in somitogIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0060042retina morphogenesis in camera-type eyeIEAbiological_process
GO:0042733embryonic digit morphogenesisIEAbiological_process
GO:0043025neuronal cell bodyIBAcellular_component
GO:0090009primitive streak formationIEAbiological_process
GO:0005041low-density lipoprotein receptor activityIDAmolecular_function
GO:0021915neural tube developmentIEAbiological_process
GO:0051091positive regulation of sequence-specific DNA bindiIDAbiological_process
GO:0060284regulation of cell developmentIEAbiological_process
GO:0060021palate developmentIEAbiological_process
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0060349bone morphogenesisIBAbiological_process
GO:0048596embryonic camera-type eye morphogenesisIEAbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIEAbiological_process
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0060059embryonic retina morphogenesis in camera-type eyeIEAbiological_process
GO:0001947heart loopingIEAbiological_process
GO:0009952anterior/posterior pattern specificationIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0035108limb morphogenesisIEAbiological_process
GO:0044335canonical Wnt receptor signaling pathway involved ICbiological_process
GO:0042074cell migration involved in gastrulationIEAbiological_process
GO:0030917midbrain-hindbrain boundary developmentIEAbiological_process
GO:0005769early endosomeIEAcellular_component
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0002053positive regulation of mesenchymal cell proliferatIEAbiological_process
GO:0060596mammary placode formationIEAbiological_process
GO:2000168negative regulation of planar cell polarity pathwaIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005901caveolaIDAcellular_component
GO:0003401axis elongationIEAbiological_process
GO:0021872forebrain generation of neuronsIEAbiological_process
GO:0021987cerebral cortex developmentIEAbiological_process
GO:2000162negative regulation of planar cell polarity pathwaIEAbiological_process
GO:0071397cellular response to cholesterolIMPbiological_process
GO:0030178negative regulation of Wnt receptor signaling pathIEAbiological_process
GO:0001843neural tube closureIEAbiological_process
GO:0017147Wnt-protein bindingIEAmolecular_function
GO:0061324canonical Wnt receptor signaling pathway involved IEAbiological_process
GO:0060444branching involved in mammary gland duct morphogenIEAbiological_process
GO:0042813Wnt-activated receptor activityIBAmolecular_function
GO:0071901negative regulation of protein serine/threonine kiIDAbiological_process
GO:0034185apolipoprotein bindingIEAmolecular_function
GO:0021795cerebral cortex cell migrationIEAbiological_process
GO:0030901midbrain developmentIEAbiological_process
GO:2000166negative regulation of planar cell polarity pathwaIEAbiological_process
GO:0045780positive regulation of bone resorptionIEAbiological_process
GO:0009880embryonic pattern specificationIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0006469negative regulation of protein kinase activityIMPbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0045787positive regulation of cell cycleIMPbiological_process
GO:0035115embryonic forelimb morphogenesisIEAbiological_process
GO:0005109frizzled bindingIPImolecular_function
GO:0021861forebrain radial glial cell differentiationIEAbiological_process
GO:0036342post-anal tail morphogenesisIEAbiological_process
GO:0090245axis elongation involved in somitogenesisIEAbiological_process
GO:0060603mammary gland duct morphogenesisIEAbiological_process
GO:0030326embryonic limb morphogenesisIBAbiological_process
GO:0045599negative regulation of fat cell differentiationIEAbiological_process
GO:2000149negative regulation of planar cell polarity pathwaIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0060325face morphogenesisIEAbiological_process
GO:0048699generation of neuronsIEAbiological_process
GO:0007268synaptic transmissionIBAbiological_process
GO:0001756somitogenesisIEAbiological_process
GO:0005102receptor bindingIPImolecular_function
GO:0061310canonical Wnt receptor signaling pathway involved IEAbiological_process
GO:0034392negative regulation of smooth muscle cell apoptotiIMPbiological_process
GO:0009950dorsal/ventral axis specificationIEAbiological_process
GO:0003344pericardium morphogenesisIEAbiological_process
GO:0060026convergent extensionIEAbiological_process
GO:0045202synapseIBAcellular_component
GO:0019534toxin transporter activityIMPmolecular_function
GO:0044332Wnt receptor signaling pathway involved in dorsal/IDAbiological_process
GO:0035261external genitalia morphogenesisIEAbiological_process
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0021794thalamus developmentIEAbiological_process
GO:0071936coreceptor activity involved in Wnt receptor signaIDAmolecular_function
GO:0009952anterior/posterior pattern specificationIBAbiological_process
GO:0060535trachea cartilage morphogenesisIEAbiological_process
GO:0030278regulation of ossificationIBAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0021987cerebral cortex developmentIBAbiological_process
GO:0001702gastrulation with mouth forming secondIEAbiological_process
GO:0021874Wnt receptor signaling pathway involved in forebraIEAbiological_process
GO:0014033neural crest cell differentiationIDAbiological_process
GO:0021943formation of radial glial scaffoldsIEAbiological_process
GO:0060070canonical Wnt receptor signaling pathwayIDAbiological_process
GO:0021587cerebellum morphogenesisIEAbiological_process
GO:2000164negative regulation of planar cell polarity pathwaIEAbiological_process
GO:0019210kinase inhibitor activityIMPmolecular_function
GO:0045778positive regulation of ossificationIEAbiological_process
GO:0035116embryonic hindlimb morphogenesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0090263positive regulation of canonical Wnt receptor signIDAbiological_process
GO:2000151negative regulation of planar cell polarity pathwaIEAbiological_process
GO:0042803protein homodimerization activityIPImolecular_function
GO:0001933negative regulation of protein phosphorylationIMPbiological_process
GO:0043235receptor complexIBAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0045598regulation of fat cell differentiationIBAbiological_process
GO:0050680negative regulation of epithelial cell proliferatiIEAbiological_process
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0044340canonical Wnt receptor signaling pathway involved ICbiological_process
GO:0071542dopaminergic neuron differentiationIEAbiological_process