Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NFAT5_HUMAN
Description:nuclear factor of activated T-cells 5, tonicity-responsive [Source:HGNC Symbol;Acc:7774]
Location:chr16 q22.1
Node attribute:PPI(target); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S357TLQTPsSPILCHPRD
S648GNGSFsSPSSSHPRD
S69TVLYIsPPPEDHPRD
S1197QTPMLsQEQAQATMphosphoELM; RegPhos
S17DLDLEsPKSLYHPRD
S484VKKEIsSPARPHPRD
S1247QSNSPsQEQQQATMphosphoELM; RegPhos
T135QQHPStPKRHTHPRD
S646IAGNGsFSSPSHPRD
S3FISLHPRD
S1367QGSPSsQEQQVATMphosphoELM; RegPhos
S573NGSFSsPSSSHHPRD
S433TLQTPsSPILCHPRD
S570IAGNGsFSSPSHPRD
S649NGSFSsPSSSHHPRD
S560VKKEIsSPARPHPRD
S145TVLYIsPPPEDHPRD
S572GNGSFsSPSSSHPRD
T59QQHPStPKRHTHPRD

Dephosphorylation site
NFAT5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000377343A1080VBIOMARTBreast Cancer21930507, 21930502
ENSP00000457593G39ETCGAOvarian Cancer21720365, 18772890
ENSP00000338806A1080VBIOMARTBreast Cancer21930507, 21930502
ENSP00000377343I440LCOSMICHead and Neck Cancer21984974
ENSP00000346420A1156VBIOMARTBreast Cancer21930507, 21930502
ENSP00000338806M525VBIOMARTHepatocellular Carcinoma21930507, 21930502

Differential expressed protein
NFAT5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NFAT5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GSK3B_HUMANNFAT5_HUMANkinase -> substrateKEGG
ATM_HUMANNFAT5_HUMANkinase -> substrateRegPhos
CHP1_HUMANNFAT5_HUMANphosphatase -> substrateKEGG
MK14_HUMANNFAT5_HUMANotherKEGG
NFAT5_HUMANPGH2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04310Wnt signaling pathway
hsa04662B cell receptor signaling pathway
hsa04370VEGF signaling pathway
hsa04360Axon guidance
hsa04650Natural killer cell mediated cytotoxicity
hsa05166HTLV-I infection
hsa04660T cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0007165signal transductionNASbiological_process
GO:0007588excretionTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0006366transcription from RNA polymerase II promoterTASbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23