Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCM2_HUMAN
Description:cerebral cavernous malformation 2 [Source:HGNC Symbol;Acc:21708]
Location:chr7 p13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S397LSTTSsSTTNGPhosphoSitePlus
Y69EKEVKyLGQLTPhosphoSitePlus
T241GASTPtHHLSLPhosphoSitePlus
S384GIITDsFGRHRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T394RRALStTSSSTPhosphoSitePlus
S15KPGIVsPFKRVPhosphoSitePlus
S398STTSSsTTNGNPhosphoSitePlus
S396ALSTTsSSTTNPhosphoSitePlus
S405GIITDsFGRHRHPRD
T239FDGAStPTHHLPhosphoSitePlus
S393HRRALsTTSSSPhosphoSitePlus
S248HLSLHsDDSSTPhosphoSitePlus

Dephosphorylation site
CCM2_HUMAN do not have dephosphorylation site.

Mutation site
CCM2_HUMAN do not have mutation site.

Differential expressed protein
CCM2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CCM2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HIPK4_HUMANCCM2_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANCCM2_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANCCM2_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANCCM2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
CCM2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIEAmolecular_function
GO:0060837blood vessel endothelial cell differentiationIEAbiological_process
GO:0035264multicellular organism growthIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0001570vasculogenesisIMPbiological_process
GO:0045216cell-cell junction organizationIEAbiological_process
GO:0001885endothelial cell developmentIEAbiological_process
GO:0048845venous blood vessel morphogenesisIEAbiological_process
GO:0051403stress-activated MAPK cascadeTASbiological_process
GO:0061154endothelial tube morphogenesisIMPbiological_process
GO:0001570vasculogenesisIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0007229integrin-mediated signaling pathwayTASbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0001568blood vessel developmentIEAbiological_process
GO:0048839inner ear developmentIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0001944vasculature developmentIEAbiological_process
GO:0060039pericardium developmentIEAbiological_process


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