| UniProt/SwissProt ID: | WWP1_HUMAN |
| Description: | WW domain containing E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:17004] |
| Location: | chr8 q21.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T575 | NVSRQtLFEDS | PhosphoSitePlus | |
| S59 | AKSSSsSNPKW | HPRD; SysPTM | |
| T365 | DPHGRtYYVDH | WW | PhosphoSitePlus |
| S59 | AKSSSsSNPKW | C2 | PhosphoSitePlus; SysPTM |
| S580 | TLFEDsFQQIM | PhosphoSitePlus; HPRD | |
| S468 | EKRVDsTDRVY | WW | PhosphoSitePlus |
| T822 | VYRHYtRNSKQ | HPRD; SysPTM | |
| Y639 | AGKNNyCLQIN | HECT | PhosphoSitePlus |
| Y543 | GPQIAyERGFR | PhosphoSitePlus | |
| T3 | ___MAtASPRS | PhosphoSitePlus | |
| Dephosphorylation site |
| WWP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000265428 | F600V | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000265428 | L630I | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000265428 | D700N | COSMIC | Lung Cancer | 20668451 | ENSP00000427793 | D700N | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| WWP1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| WWP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ACVR1_HUMAN | WWP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BTK_HUMAN | WWP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAP70_HUMAN | WWP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KSYK_HUMAN | WWP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| LCK_HUMAN | WWP1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| WWP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004842 | ubiquitin-protein ligase activity | IEA | molecular_function |
| GO:0016567 | protein ubiquitination | TAS | biological_process |
| GO:0042787 | protein ubiquitination involved in ubiquitin-depen | IBA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0000151 | ubiquitin ligase complex | NAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0046718 | viral entry into host cell | TAS | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0043161 | proteasomal ubiquitin-dependent protein catabolic | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007417 | central nervous system development | NAS | biological_process |
| GO:0005737 | cytoplasm | IBA | cellular_component |
| GO:0005634 | nucleus | IBA | cellular_component |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0007165 | signal transduction | NAS | biological_process |
| GO:0006464 | cellular protein modification process | IEA | biological_process |