Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:WWP1_HUMAN
Description:WW domain containing E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:17004]
Location:chr8 q21.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T575NVSRQtLFEDSPhosphoSitePlus
S59AKSSSsSNPKWHPRD; SysPTM
T365DPHGRtYYVDHWWPhosphoSitePlus
S59AKSSSsSNPKWC2PhosphoSitePlus; SysPTM
S580TLFEDsFQQIMPhosphoSitePlus; HPRD
S468EKRVDsTDRVYWWPhosphoSitePlus
T822VYRHYtRNSKQHPRD; SysPTM
Y639AGKNNyCLQINHECTPhosphoSitePlus
Y543GPQIAyERGFRPhosphoSitePlus
T3___MAtASPRSPhosphoSitePlus

Dephosphorylation site
WWP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265428F600VBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000265428L630IBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000265428D700NCOSMICLung Cancer20668451
ENSP00000427793D700NCOSMICLung Cancer20668451

Differential expressed protein
WWP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
WWP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ACVR1_HUMANWWP1_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANWWP1_HUMANkinase -> substrateRobert H Newman (2013)
ZAP70_HUMANWWP1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANWWP1_HUMANkinase -> substrateRobert H Newman (2013)
LCK_HUMANWWP1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
WWP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004842ubiquitin-protein ligase activityIEAmolecular_function
GO:0016567protein ubiquitinationTASbiological_process
GO:0042787protein ubiquitination involved in ubiquitin-depenIBAbiological_process
GO:0005829cytosolTAScellular_component
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0000151ubiquitin ligase complexNAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0046718viral entry into host cellTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0043161proteasomal ubiquitin-dependent protein catabolic IEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007417central nervous system developmentNASbiological_process
GO:0005737cytoplasmIBAcellular_component
GO:0005634nucleusIBAcellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0007165signal transductionNASbiological_process
GO:0006464cellular protein modification processIEAbiological_process


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