Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:JAK1_HUMAN
Description:Janus kinase 1 [Source:HGNC Symbol;Acc:6190]
Location:chr1 p31.3
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1022ETDKEyYTVKDautocatalysisRegPhos
S216LPKDIsYKRYIPhosphoSitePlus
T1030TKAIEtDKEYYPkinase_TyrPhosphoSitePlus
S738PFIKLsDPGIPPkinase_TyrPhosphoSitePlus
Y1035TDKEYyTVKDDJAK3HPRD
Y1023TDKEYyTVKDDJAK3phosphoELM; RegPhos
S228ETLNKsIRQRNPhosphoSitePlus
Y412SLVDGyFRLTAPhosphoSitePlus
Y1035TDKEYyTVKDDPkinase_TyrPhosphoSitePlus
Y568EWQPVyPMSQLPhosphoSitePlus
Y220ISYKRyIPETLPhosphoSitePlus
Y217PKDISyKRYIPPhosphoSitePlus
T1036DKEYYtVKDDRPkinase_TyrPhosphoSitePlus
T688SDVLTtPWKFKPkinase_TyrPhosphoSitePlus
S1043KDDRDsPVFWYPkinase_TyrPhosphoSitePlus
Y3___MQyLNIKEPhosphoSitePlus
T1107TRLVNtLKEGKPkinase_TyrPhosphoSitePlus
T688SDVLTtPWKFKHPRD
Y1023TDKEYyTVKDDphosphoELM
Y208ISYKRyIPETLphosphoELM; RegPhos; SysPTM
Y1022ETDKEyYTVKDJAK3phosphoELM; RegPhos
T1107TRLVNtLKEGKHPRD
Y1125CPDEVyQLMRKPkinase_TyrPhosphoSitePlus
Y1034ETDKEyYTVKDJAK3HPRD
T119TNWHGtNDNEQHPRD
S574PMSQLsFDRILPhosphoSitePlus
T687KSDVLtTPWKFPkinase_TyrPhosphoSitePlus
Y1034ETDKEyYTVKDPkinase_TyrPhosphoSitePlus
Y1022ETDKEyYTVKDphosphoELM
T687KSDVLtTPWKFHPRD
S125NDNEQsVWRHSHPRD

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1034AIETDKEyYTVKDDRPTPRCHPRD
Y1034AIETDKEyYTVKDDRPTPN2HPRD
Y1035IETDKEYyTVKDDRDPTPRCHPRD
Y1035IETDKEYyTVKDDRDPTPN2HPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000343204R724QCOSMICLymphoma19764985
ENSP00000343204G882ECOSMICNeoplasms by Histologic Type16474838
ENSP00000343204K204MCOSMICLymphoma18362173
ENSP00000343204E966VCOSMICLymphoma19176360
ENSP00000343204V623ACOSMICLymphoma18160671
ENSP00000343204Y652HCOSMICLymphoma21551237
ENSP00000343204H647YCOSMICBreast Cancer18559588
ENSP00000343204M828ICOSMICLung Cancer18948947
ENSP00000343204V645FCOSMICHepatocellular Carcinoma19239328
ENSP00000343204V1045KCOSMICNeoplasms by Histologic Type16474838
ENSP00000343204S646FCOSMICLymphoma19470474
ENSP00000343204T782MCOSMICLung Cancer18559588
ENSP00000343204V658FCOSMICLymphoma19838194
ENSP00000343204L653FCOSMICLymphoma18362173
ENSP00000343204S512LCOSMICLymphoma19764985
ENSP00000343204R879HCOSMICLymphoma18362173
ENSP00000343204W467*COSMICBreast Cancer20668451
ENSP00000343204D660HCOSMICLung Cancer18948947
ENSP00000343204Q644HCOSMICHepatocellular Carcinoma19239328
ENSP00000343204A634DCOSMICLymphoma18362173
ENSP00000343204S703TCOSMICLymphoma21390130
ENSP00000343204L783FCOSMICLymphoma18559588
ENSP00000343204S771CCOSMICNeoplasms by Histologic Type16474838
ENSP00000343204K648NCOSMICLymphoma21551237
ENSP00000343204Y463SCOSMICNeoplasms by Histologic Type16474838
ENSP00000343204T478SCOSMICLymphoma18160671
ENSP00000343204M642ICOSMICNeoplasms by Histologic Type16474838
ENSP00000343204T593MCOSMICIntestines Cancer19900094
ENSP00000343204W1047GCOSMICNeoplasms by Histologic Type16474838
ENSP00000343204E637KCOSMICBreast Cancer20668451

Differential expressed protein
JAK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
JAK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JAK1_HUMANSTAT4_HUMANkinase -> substrateRegPhos
JAK3_HUMANJAK1_HUMANkinase -> substrateRegPhos; NetPath
KPCZ_HUMANJAK1_HUMANkinase -> substrateNetPath
ZAGL2_HUMANJAK1_HUMANkinase -> substrateRegPhos
I22R2_HUMANJAK1_HUMANkinase -> substrateKEGG
JAK1_HUMANSTA5B_HUMANkinase -> substrateRegPhos
JAK1_HUMANJAK1_HUMANkinase -> substrateNetPath
JAK1_HUMANSTAT3_HUMANkinase -> substrateHPRD; RegPhos
JAK1_HUMANSTAT1_HUMANkinase -> substrateKEGG; HPRD; RegPhos
JAK1_HUMANSTA5A_HUMANkinase -> substrateRegPhos
JAK1_HUMANI10R1_HUMANkinase -> substrateRegPhos
JAK1_HUMANIRS2_HUMANkinase -> substrateNetPath
JAK1_HUMANSTAT6_HUMANkinase -> substrateRegPhos; NetPath
JAK1_HUMANTYK2_HUMANkinase -> substrateRegPhos
JAK1_HUMANIL4RA_HUMANkinase -> substrateNetPath
JAK1_HUMANIRS1_HUMANkinase -> substrateNetPath
JAK1_HUMANFES_HUMANkinase -> substrateNetPath
JAK1_HUMANSH2B1_HUMANkinase -> substrateRegPhos
JAK1_HUMANPI3R5_HUMANkinase -> substrateKEGG
JAK1_HUMANPTN11_HUMANkinase -> substrateKEGG
JAK1_HUMANBTK_HUMANkinase -> substrateNetPath
JAK1_HUMANSTAM2_HUMANkinase -> substrateNetPath
JAK1_HUMANSHIP1_HUMANkinase -> substrateNetPath
JAK1_HUMANSHC1_HUMANkinase -> substrateNetPath
JAK1_HUMANINGR1_HUMANkinase -> substrateRegPhos
JAK1_HUMANIL2RB_HUMANkinase -> substrateHPRD; RegPhos; NetPath
JAK1_HUMANE2AK2_HUMANkinase -> substrateHPRD
JAK1_HUMANKSYK_HUMANkinase -> substrateNetPath
JAK1_HUMANSOCS3_HUMANkinase -> substrateNetPath
JAK1_HUMANSTAT2_HUMANkinase -> substrateHPRD; RegPhos
PTN6_HUMANJAK1_HUMANphosphatase -> substrateNetPath
PTPRC_HUMANJAK1_HUMANphosphatase -> substrateHPRD
PTN2_HUMANJAK1_HUMANphosphatase -> substrateHPRD
STAM2_HUMANJAK1_HUMANotherKEGG
PORCN_HUMANJAK1_HUMANotherKEGG
PTN6_HUMANJAK1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05152Tuberculosis
hsa05200Pathways in cancer
hsa05160Hepatitis C
hsa05212Pancreatic cancer
hsa05140Leishmaniasis
hsa05168Herpes simplex infection
hsa04630Jak-STAT signaling pathway
hsa05166HTLV-I infection
hsa05203Viral carcinogenesis
hsa05164Influenza A
hsa05169Epstein-Barr virus infection
hsa04380Osteoclast differentiation
hsa05145Toxoplasmosis
hsa05162Measles

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIDAcellular_component
GO:0004713protein tyrosine kinase activityTASmolecular_function
GO:0046677response to antibioticIDAbiological_process
GO:0012505endomembrane systemIEAcellular_component
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0004715non-membrane spanning protein tyrosine kinase actiIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0019221cytokine-mediated signaling pathwayTASbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0060337type I interferon-mediated signaling pathwayTASbiological_process
GO:0060338regulation of type I interferon-mediated signalingTASbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0035556intracellular signal transductionTASbiological_process
GO:0007167enzyme linked receptor protein signaling pathwayIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0060333interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0005856cytoskeletonIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0060334regulation of interferon-gamma-mediated signaling TASbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0007243intracellular protein kinase cascadeIEAbiological_process
GO:0005131growth hormone receptor bindingISSmolecular_function


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