| UniProt/SwissProt ID: | ZW10_HUMAN |
| Description: | zw10 kinetochore protein [Source:HGNC Symbol;Acc:13194] |
| Location: | chr11 q23.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T438 | VPELPtPDEDN | Zw10 | PhosphoSitePlus; SysPTM |
| T133 | EKKYVtGAQRL | HPRD | |
| S12 | EVLAHsGRLEK | Zw10 | PhosphoSitePlus |
| Y455 | VSNTQyHEVMN | Zw10 | PhosphoSitePlus |
| T386 | LKGDTtDLLKY | Zw10 | PhosphoSitePlus |
| S611 | SARNFsNMDDE | Zw10 | PhosphoSitePlus |
| T438 | VPELPtPDEDN | HPRD; phosphoELM; SysPTM | |
| T22 | KEDLGtRISRL | Zw10 | PhosphoSitePlus |
| Y349 | KNCLVySIPTN | Zw10 | PhosphoSitePlus |
| T133 | EKKYVtGAQRL | Zw10 | PhosphoSitePlus |
| S662 | LNTAIsEVIGK | HPRD | |
| T386 | LKGDTtDLLKY | HPRD | |
| Dephosphorylation site |
| ZW10_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000200135 | E703K | COSMIC | Melanoma | 21499247 | ENSP00000200135 | P714S | COSMIC | Central Nervous System Neoplasms | 18772396 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000200135 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| ZW10_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| BTK_HUMAN | ZW10_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ZW10_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0034501 | protein localization to kinetochore | IMP | biological_process |
| GO:0006461 | protein complex assembly | IDA | biological_process |
| GO:0007080 | mitotic metaphase plate congression | IMP | biological_process |
| GO:0005789 | endoplasmic reticulum membrane | IEA | cellular_component |
| GO:0007096 | regulation of exit from mitosis | IDA | biological_process |
| GO:0007093 | mitotic cell cycle checkpoint | IDA | biological_process |
| GO:0000087 | M phase of mitotic cell cycle | TAS | biological_process |
| GO:0019237 | centromeric DNA binding | TAS | molecular_function |
| GO:0005828 | kinetochore microtubule | IDA | cellular_component |
| GO:0000776 | kinetochore | IDA | cellular_component |
| GO:0000922 | spindle pole | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0000132 | establishment of mitotic spindle orientation | IMP | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0000070 | mitotic sister chromatid segregation | IDA | biological_process |
| GO:0006888 | ER to Golgi vesicle-mediated transport | IMP | biological_process |
| GO:0000777 | condensed chromosome kinetochore | IEA | cellular_component |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0000775 | chromosome, centromeric region | IEA | cellular_component |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0007067 | mitosis | IEA | biological_process |
| GO:0000278 | mitotic cell cycle | TAS | biological_process |
| GO:0007126 | meiosis | TAS | biological_process |
| GO:0000236 | mitotic prometaphase | TAS | biological_process |
| GO:0005783 | endoplasmic reticulum | IDA | cellular_component |