Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ZW10_HUMAN
Description:zw10 kinetochore protein [Source:HGNC Symbol;Acc:13194]
Location:chr11 q23.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T438VPELPtPDEDNZw10PhosphoSitePlus; SysPTM
T133EKKYVtGAQRLHPRD
S12EVLAHsGRLEKZw10PhosphoSitePlus
Y455VSNTQyHEVMNZw10PhosphoSitePlus
T386LKGDTtDLLKYZw10PhosphoSitePlus
S611SARNFsNMDDEZw10PhosphoSitePlus
T438VPELPtPDEDNHPRD; phosphoELM; SysPTM
T22KEDLGtRISRLZw10PhosphoSitePlus
Y349KNCLVySIPTNZw10PhosphoSitePlus
T133EKKYVtGAQRLZw10PhosphoSitePlus
S662LNTAIsEVIGKHPRD
T386LKGDTtDLLKYHPRD

Dephosphorylation site
ZW10_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000200135E703KCOSMICMelanoma21499247
ENSP00000200135P714SCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000200135Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
ZW10_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
BTK_HUMANZW10_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ZW10_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0034501protein localization to kinetochoreIMPbiological_process
GO:0006461protein complex assemblyIDAbiological_process
GO:0007080mitotic metaphase plate congressionIMPbiological_process
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0007096regulation of exit from mitosisIDAbiological_process
GO:0007093mitotic cell cycle checkpointIDAbiological_process
GO:0000087M phase of mitotic cell cycleTASbiological_process
GO:0019237centromeric DNA bindingTASmolecular_function
GO:0005828kinetochore microtubuleIDAcellular_component
GO:0000776kinetochoreIDAcellular_component
GO:0000922spindle poleIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0000132establishment of mitotic spindle orientationIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0000070mitotic sister chromatid segregationIDAbiological_process
GO:0006888ER to Golgi vesicle-mediated transportIMPbiological_process
GO:0000777condensed chromosome kinetochoreIEAcellular_component
GO:0051301cell divisionIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0000775chromosome, centromeric regionIEAcellular_component
GO:0015031protein transportIEAbiological_process
GO:0007067mitosisIEAbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0007126meiosisTASbiological_process
GO:0000236mitotic prometaphaseTASbiological_process
GO:0005783endoplasmic reticulumIDAcellular_component


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