Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NFAC3_HUMAN
Description:nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 [Source:HGNC Symbol;Acc:7777]
Location:chr16 q22.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S163RESSLsPSPASJNK2RegPhos
S277GKRRHsSAEVCPhosphoSitePlus
S207RFTLGsPLTSPPhosphoSitePlus
S165SSLSPsPASSIJNK2(MAPK9RegPhos
T204AAARFtLGSPLPhosphoSitePlus
S215TSPGGsPGGCPCK1_groupphosphoELM; RegPhos
S366DQGSLsPARETPhosphoSitePlus; HPRD
S730QTQRPsSDSGCPhosphoSitePlus
S163RESSLsPSPASJNK2(MAPK9RegPhos
S742HDSVLsGQRSLPhosphoSitePlus
S1048DMSQIsVSQGAPhosphoSitePlus
S180WFSDAsSCESLPhosphoSitePlus
T204AAARFtLGSPLCK1_groupphosphoELM; RegPhos
S207RFTLGsPLTSPCSNK1A1HPRD
S215TSPGGsPGGCPCK1aRegPhos
S82SFQLQsHKNYEPhosphoSitePlus
S207RFTLGsPLTSPCK1_groupphosphoELM; RegPhos
S546LKLRNsDIELRRHDPhosphoSitePlus
S184ASSCEsLSHIYPhosphoSitePlus
T268PSSRPtSPCGKPhosphoSitePlus
S215TSPGGsPGGCPCSNK1A1HPRD
S163RESSLsPSPASPhosphoSitePlus
S163RESSLsPSPASMAPK9HPRD; phosphoELM
S165SSLSPsPASSIPhosphoSitePlus
S416IFRTSsLPPLDPhosphoSitePlus
S211GSPLTsPGGSPCK1_groupphosphoELM; RegPhos
T210LGSPLtSPGGSCK1aRegPhos
S364SDDQGsLSPARPhosphoSitePlus
T210LGSPLtSPGGSCSNK1A1HPRD
S415PIFRTsSLPPLPhosphoSitePlus
S207RFTLGsPLTSPCK1aRegPhos
S269SSRPTsPCGKRPhosphoSitePlus
T210LGSPLtSPGGSPhosphoSitePlus
S165SSLSPsPASSIMAPK9HPRD; phosphoELM
S211GSPLTsPGGSPCK1aRegPhos
S1063QAPLPsPESLDPhosphoSitePlus
T210LGSPLtSPGGSCK1_groupphosphoELM; RegPhos
S265ASGPSsRPTSPPhosphoSitePlus
T89KNYEGtCEIPEPhosphoSitePlus
S177SRSWFsDASSCPhosphoSitePlus
T204AAARFtLGSPLCK1aRegPhos
S172ASSISsRSWFSPhosphoSitePlus
S731TQRPSsDSGCSPhosphoSitePlus
S211GSPLTsPGGSPCSNK1A1HPRD
S181FSDASsCESLSPhosphoSitePlus
S165SSLSPsPASSIJNK2RegPhos
Y150SRDHLyLPLEPPhosphoSitePlus
S186SCESLsHIYDDPhosphoSitePlus
S211GSPLTsPGGSPPhosphoSitePlus
S1045IGRDMsQISVSPhosphoSitePlus
Y884LQSMGyHCSNTPhosphoSitePlus
T204AAARFtLGSPLCSNK1A1HPRD
Y86QSHKNyEGTCEPhosphoSitePlus
S344KTRKTsEDQAAPhosphoSitePlus
S215TSPGGsPGGCPPhosphoSitePlus

Dephosphorylation site
NFAC3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000331324R444*COSMICSkin Cancer21984974
ENSP00000300659G451RBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000331324D386YCOSMICHepatocellular Carcinoma21822264
ENSP00000300659P270SCOSMICSkin Cancer21984974
ENSP00000300659D386YCOSMICHepatocellular Carcinoma21822264
ENSP00000331324G451RCOSMICPancreatic Cancer
ENSP00000331324P270SCOSMICSkin Cancer21984974
ENSP00000331324Q79*BIOMARTBreast Cancer21930507, 21930502
ENSP00000331324L287VCOSMICHead and Neck Cancer21798897
ENSP00000264008Q79*BIOMARTBreast Cancer21930507, 21930502
ENSP00000331324H668YCOSMICHead and Neck Cancer21798893
ENSP00000300659R444*COSMICSkin Cancer21984974
ENSP00000300659Q79*BIOMARTBreast Cancer21930507, 21930502
ENSP00000300659H668YCOSMICHead and Neck Cancer21798893

Differential expressed protein
NFAC3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NFAC3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANNFAC3_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANNFAC3_HUMANkinase -> substrateRobert H Newman (2013)
PRKY_HUMANNFAC3_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANNFAC3_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANNFAC3_HUMANkinase -> substrateHPRD
KC1D_HUMANNFAC3_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANNFAC3_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
BTK_HUMANNFAC3_HUMANkinase -> substrateRobert H Newman (2013)
KC1G1_HUMANNFAC3_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANNFAC3_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANNFAC3_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANNFAC3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04310Wnt signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04662B cell receptor signaling pathway
hsa04360Axon guidance
hsa04370VEGF signaling pathway
hsa05166HTLV-I infection
hsa04660T cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005730nucleolusIDAcellular_component
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0055001muscle cell developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0051145smooth muscle cell differentiationIEAbiological_process
GO:0071285cellular response to lithium ionIEAbiological_process
GO:0045333cellular respirationIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0006954inflammatory responseTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0001569patterning of blood vesselsIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0007507heart developmentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process


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