| UniProt/SwissProt ID: | PER3_HUMAN |
| Description: | period circadian clock 3 [Source:HGNC Symbol;Acc:8847] |
| Location: | chr1 p36.23 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y719 | KAKYSyFQGDS | PhosphoSitePlus | |
| S480 | QLYIEsMTKSS | PhosphoSitePlus; HPRD | |
| T388 | EDVFAtKIKKM | PhosphoSitePlus | |
| Y408 | LQEQIyKLLLQ | PhosphoSitePlus | |
| Y463 | TLQQVyASVNK | PhosphoSitePlus | |
| S634 | QCGYSsTIVHV | CSNK1E | HPRD |
| S625 | MLSLGsGISQC | CSNK1E | HPRD |
| T755 | SSSSNtGSGPR | PhosphoSitePlus | |
| T1072 | SSIYLtSSVYS | PhosphoSitePlus | |
| S753 | PDSSSsNTGSG | PhosphoSitePlus | |
| T635 | CGYSStIVHVP | CSNK1E | HPRD |
| S1073 | SIYLTsSVYSS | PhosphoSitePlus | |
| S622 | STAMLsLGSGI | CSNK1E | HPRD |
| T482 | YIESMtKSSFK | HPRD | |
| S628 | LGSGIsQCGYS | CSNK1E | HPRD |
| Y1119 | RILMTyQVPER | PhosphoSitePlus | |
| S757 | SSNTGsGPRRG | PhosphoSitePlus | |
| S633 | SQCGYsSTIVH | CSNK1E | HPRD |
| S1048 | VLSTGsPPSES | PhosphoSitePlus | |
| Dephosphorylation site |
| PER3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000355031 | P1032S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000355031 | P995L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000366755 | P1041S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000355031 | T566I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000355031 | T566I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000355031 | K998E | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000355031 | S753L | COSMIC | Melanoma | 21499247 | ENSP00000366755 | K224E | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000355031 | K223E | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| PER3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PER3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| NRBP2_HUMAN | PER3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1E_HUMAN | PER3_HUMAN | kinase -> substrate | HPRD |
| BTK_HUMAN | PER3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04710 | Circadian rhythm - mammal |
| hsa05168 | Herpes simplex infection |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0007623 | circadian rhythm | IEA | biological_process |