Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PER3_HUMAN
Description:period circadian clock 3 [Source:HGNC Symbol;Acc:8847]
Location:chr1 p36.23
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y719KAKYSyFQGDSPhosphoSitePlus
S480QLYIEsMTKSSPhosphoSitePlus; HPRD
T388EDVFAtKIKKMPhosphoSitePlus
Y408LQEQIyKLLLQPhosphoSitePlus
Y463TLQQVyASVNKPhosphoSitePlus
S634QCGYSsTIVHVCSNK1EHPRD
S625MLSLGsGISQCCSNK1EHPRD
T755SSSSNtGSGPRPhosphoSitePlus
T1072SSIYLtSSVYSPhosphoSitePlus
S753PDSSSsNTGSGPhosphoSitePlus
T635CGYSStIVHVPCSNK1EHPRD
S1073SIYLTsSVYSSPhosphoSitePlus
S622STAMLsLGSGICSNK1EHPRD
T482YIESMtKSSFKHPRD
S628LGSGIsQCGYSCSNK1EHPRD
Y1119RILMTyQVPERPhosphoSitePlus
S757SSNTGsGPRRGPhosphoSitePlus
S633SQCGYsSTIVHCSNK1EHPRD
S1048VLSTGsPPSESPhosphoSitePlus

Dephosphorylation site
PER3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000355031P1032SBIOMARTBreast Cancer21930507, 21930502
ENSP00000355031P995LCOSMICHead and Neck Cancer21798893
ENSP00000366755P1041SBIOMARTBreast Cancer21930507, 21930502
ENSP00000355031T566ICOSMICOvarian Cancer21720365
ENSP00000355031T566ITCGAOvarian Cancer21720365, 18772890
ENSP00000355031K998EBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000355031S753LCOSMICMelanoma21499247
ENSP00000366755K224EBIOMARTBreast Cancer21930507, 21930502
ENSP00000355031K223EBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
PER3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PER3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
NRBP2_HUMANPER3_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANPER3_HUMANkinase -> substrateHPRD
BTK_HUMANPER3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04710Circadian rhythm - mammal
hsa05168Herpes simplex infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0004871signal transducer activityIEAmolecular_function
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007623circadian rhythmIEAbiological_process


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