Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CD19_HUMAN
Description:CD19 molecule [Source:HGNC Symbol;Acc:1633]
Location:chr16 p11.2
Node attribute:PPI(source); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y531EDADSyENMDNBTKRegPhos
Y348GPQNQyGNVLSPhosphoSitePlus; phosphoELM; RegPhos
Y500LGSQSyEDMRGBTKRegPhos
Y378GTAPSyGNPSSErk2RegPhos
Y508MRGILyAAPQLPhosphoSitePlus
Y348GPQNQyGNVLSErk2RegPhos
S530EEDADsYENMDPhosphoSitePlus
Y500LGSQSyEDMRGLYNRegPhos
Y500LGSQSyEDMRGLynphosphoELM; RegPhos
Y378GTAPSyGNPSSPhosphoSitePlus; phosphoELM; RegPhos
T475QPVARtMDFLSPhosphoSitePlus
S497ATSLGsQSYEDPhosphoSitePlus; phosphoELM; RegPhos
Y409EEGEGyEEPDSPhosphoSitePlus; phosphoELM; RegPhos
T356VLSLPtPTSGLPhosphoSitePlus
T337RFFKVtPPPGSPhosphoSitePlus
Y531EDADSyENMDNLynphosphoELM; RegPhos
Y531EDADSyENMDNLYNRegPhos
Y409EEGEGyEEPDSLYNRegPhos
Y409EEGEGyEEPDSErk2RegPhos
S499SLGSQsYEDMRPhosphoSitePlus
Y500LGSQSyEDMRGPhosphoSitePlus; phosphoELM
Y531EDADSyENMDNPhosphoSitePlus; phosphoELM
Y508MRGILyAAPQLABL1RegPhos
Y439QDGSGyENPEDErk2RegPhos
S227PKSLLsLELKDRegPhos
Y439QDGSGyENPEDPhosphoSitePlus; phosphoELM; RegPhos

Dephosphorylation site
CD19_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000313419E55DCOSMICOvarian Cancer21720365
ENSP00000313419G341ECOSMICSkin Cancer21984974
ENSP00000313419S140YCOSMICOvarian Cancer21720365
ENSP00000313419P172TBIOMARTBreast Cancer21930507, 21930502
ENSP00000313419G373SCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
CD19_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CD19_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
MK01_HUMANCD19_HUMANkinase -> substrateHPRD
ZAGL2_HUMANCD19_HUMANkinase -> substrateRegPhos
LYN_HUMANCD19_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
ABL1_HUMANCD19_HUMANkinase -> substrateHPRD; RegPhos
BTK_HUMANCD19_HUMANkinase -> substrateRegPhos
CD19_HUMANPI3R5_HUMANotherKEGG
CD19_HUMANVAV3_HUMANotherKEGG
PAX5_HUMANCD19_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05169Epstein-Barr virus infection
hsa04662B cell receptor signaling pathway
hsa05340Primary immunodeficiency
hsa04640Hematopoietic cell lineage

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005887integral to plasma membraneTAScellular_component
GO:0009897external side of plasma membraneIDAcellular_component
GO:0005886plasma membraneTAScellular_component
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0050776regulation of immune responseTASbiological_process
GO:0005057receptor signaling protein activityTASmolecular_function
GO:0006968cellular defense responseTASbiological_process
GO:0005515protein bindingIEAmolecular_function


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