| UniProt/SwissProt ID: | CD19_HUMAN |
| Description: | CD19 molecule [Source:HGNC Symbol;Acc:1633] |
| Location: | chr16 p11.2 |
| Node attribute: | PPI(source); substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y531 | EDADSyENMDN | BTK | RegPhos |
| Y348 | GPQNQyGNVLS | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y500 | LGSQSyEDMRG | BTK | RegPhos |
| Y378 | GTAPSyGNPSS | Erk2 | RegPhos |
| Y508 | MRGILyAAPQL | PhosphoSitePlus | |
| Y348 | GPQNQyGNVLS | Erk2 | RegPhos |
| S530 | EEDADsYENMD | PhosphoSitePlus | |
| Y500 | LGSQSyEDMRG | LYN | RegPhos |
| Y500 | LGSQSyEDMRG | Lyn | phosphoELM; RegPhos |
| Y378 | GTAPSyGNPSS | PhosphoSitePlus; phosphoELM; RegPhos | |
| T475 | QPVARtMDFLS | PhosphoSitePlus | |
| S497 | ATSLGsQSYED | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y409 | EEGEGyEEPDS | PhosphoSitePlus; phosphoELM; RegPhos | |
| T356 | VLSLPtPTSGL | PhosphoSitePlus | |
| T337 | RFFKVtPPPGS | PhosphoSitePlus | |
| Y531 | EDADSyENMDN | Lyn | phosphoELM; RegPhos |
| Y531 | EDADSyENMDN | LYN | RegPhos |
| Y409 | EEGEGyEEPDS | LYN | RegPhos |
| Y409 | EEGEGyEEPDS | Erk2 | RegPhos |
| S499 | SLGSQsYEDMR | PhosphoSitePlus | |
| Y500 | LGSQSyEDMRG | PhosphoSitePlus; phosphoELM | |
| Y531 | EDADSyENMDN | PhosphoSitePlus; phosphoELM | |
| Y508 | MRGILyAAPQL | ABL1 | RegPhos |
| Y439 | QDGSGyENPED | Erk2 | RegPhos |
| S227 | PKSLLsLELKD | RegPhos | |
| Y439 | QDGSGyENPED | PhosphoSitePlus; phosphoELM; RegPhos | |
| Dephosphorylation site |
| CD19_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000313419 | E55D | COSMIC | Ovarian Cancer | 21720365 | ENSP00000313419 | G341E | COSMIC | Skin Cancer | 21984974 | ENSP00000313419 | S140Y | COSMIC | Ovarian Cancer | 21720365 | ENSP00000313419 | P172T | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000313419 | G373S | COSMIC | Central Nervous System Neoplasms | 18772396 |
| Differential expressed protein |
| CD19_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CD19_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| MK01_HUMAN | CD19_HUMAN | kinase -> substrate | HPRD |
| ZAGL2_HUMAN | CD19_HUMAN | kinase -> substrate | RegPhos |
| LYN_HUMAN | CD19_HUMAN | kinase -> substrate | RegPhos; NetPath; Robert H Newman (2013) |
| ABL1_HUMAN | CD19_HUMAN | kinase -> substrate | HPRD; RegPhos |
| BTK_HUMAN | CD19_HUMAN | kinase -> substrate | RegPhos |
| CD19_HUMAN | PI3R5_HUMAN | other | KEGG |
| CD19_HUMAN | VAV3_HUMAN | other | KEGG |
| PAX5_HUMAN | CD19_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05169 | Epstein-Barr virus infection |
| hsa04662 | B cell receptor signaling pathway |
| hsa05340 | Primary immunodeficiency |
| hsa04640 | Hematopoietic cell lineage |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0009897 | external side of plasma membrane | IDA | cellular_component |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |
| GO:0050776 | regulation of immune response | TAS | biological_process |
| GO:0005057 | receptor signaling protein activity | TAS | molecular_function |
| GO:0006968 | cellular defense response | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |