Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TEC_HUMAN
Description:tec protein tyrosine kinase [Source:HGNC Symbol;Acc:11719]
Location:chr4 p11
Node attribute:kinase; substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y343VTRLRyPVSVKPhosphoSitePlus
Y281SQPGLyTVSLYSH2PhosphoSitePlus
Y206ERGQEyLILEKTecRegPhos
Y519VLDDQyTSSSGPkinase_TyrPhosphoSitePlus
Y228YGNEGyIPSNYSH3_1PhosphoSitePlus
Y90DANTLyIFAPSPHPhosphoSitePlus
Y206ERGQEyLILEKTECHPRD; phosphoELM; RegPhos
Y286YTVSLyTKFGGSH2PhosphoSitePlus
Y233YIPSNyVTGKKPhosphoSitePlus
Y120NIMIKyHPKFWBTKPhosphoSitePlus
T88VHDANtLYIFAPHPhosphoSitePlus
T520LDDQYtSSSGAPkinase_TyrPhosphoSitePlus
Y519VLDDQyTSSSGautocatalysis RegPhos
Y223RARDKyGNEGYSH3_1PhosphoSitePlus
Y206ERGQEyLILEKBTKphosphoELM; RegPhos
Y206ERGQEyLILEKSH3_1PhosphoSitePlus
Y206ERGQEyLILEKITKphosphoELM; RegPhos
Y188IVVAMyDFQAASH3_1PhosphoSitePlus
Y360TAGFSyEKWEIPhosphoSitePlus

Dephosphorylation site
TEC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000370912R166GDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000370912R583LDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000370912S359IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000370912R563KGreenman2007, HPILung Cancer16140923, 17344846, 18428421

Differential expressed protein
TEC_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TEC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TEC_HUMANTEC_HUMANkinase -> substrateNetPath
LYN_HUMANTEC_HUMANkinase -> substrateNetPath
TEC_HUMANPLCG1_HUMANkinase -> substrateNetPath
TEC_HUMANPLCG2_HUMANkinase -> substrateNetPath
TEC_HUMANSTAP1_HUMANkinase -> substrateNetPath
TEC_HUMANPTN18_HUMANkinase -> substrateRegPhos; NetPath
TEC_HUMANNAR4_HUMANkinase -> substrateNetPath
TEC_HUMANBTK_HUMANkinase -> substrateHPRD; RegPhos
BTK_HUMANTEC_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ITK_HUMANTEC_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
TEC_HUMANBMX_HUMANkinase -> substrateRegPhos
PTN18_HUMANTEC_HUMANphosphatase -> substrateNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04380Osteoclast differentiation
hsa04660T cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007229integrin-mediated signaling pathwayIDAbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0010543regulation of platelet activationIDAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0004672protein kinase activityIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005886plasma membraneIEAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0007243intracellular protein kinase cascadeTASbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0004715non-membrane spanning protein tyrosine kinase actiIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005856cytoskeletonIDAcellular_component
GO:0050853B cell receptor signaling pathwayIDAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process


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