Phosphorylation

Protein information

UniProt/SwissProt ID:	TEC_HUMAN
Description:	tec protein tyrosine kinase [Source:HGNC Symbol;Acc:11719]
Location:	chr4 p11
Node attribute:	kinase; substrate

Position	PhosphoPeptide	Catalytic kinase	Source
Y343	VTRLRyPVSVK		PhosphoSitePlus
Y281	SQPGLyTVSLY	SH2	PhosphoSitePlus
Y206	ERGQEyLILEK	Tec	RegPhos
Y519	VLDDQyTSSSG	Pkinase_Tyr	PhosphoSitePlus
Y228	YGNEGyIPSNY	SH3_1	PhosphoSitePlus
Y90	DANTLyIFAPS	PH	PhosphoSitePlus
Y206	ERGQEyLILEK	TEC	HPRD; phosphoELM; RegPhos
Y286	YTVSLyTKFGG	SH2	PhosphoSitePlus
Y233	YIPSNyVTGKK		PhosphoSitePlus
Y120	NIMIKyHPKFW	BTK	PhosphoSitePlus
T88	VHDANtLYIFA	PH	PhosphoSitePlus
T520	LDDQYtSSSGA	Pkinase_Tyr	PhosphoSitePlus
Y519	VLDDQyTSSSG	autocatalysis	RegPhos
Y223	RARDKyGNEGY	SH3_1	PhosphoSitePlus
Y206	ERGQEyLILEK	BTK	phosphoELM; RegPhos
Y206	ERGQEyLILEK	SH3_1	PhosphoSitePlus
Y206	ERGQEyLILEK	ITK	phosphoELM; RegPhos
Y188	IVVAMyDFQAA	SH3_1	PhosphoSitePlus
Y360	TAGFSyEKWEI		PhosphoSitePlus

TEC_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000370912	R166G	Ding2008, BIOMART	Lung Cancer	18948947, 21930507, 21930502
ENSP00000370912	R583L	Ding2008, BIOMART	Lung Cancer	18948947, 21930507, 21930502
ENSP00000370912	S359I	Ding2008, BIOMART	Lung Cancer	18948947, 21930507, 21930502
ENSP00000370912	R563K	Greenman2007, HPI	Lung Cancer	16140923, 17344846, 18428421

TEC_HUMAN is not differential expressed protein.

TEC_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
TEC_HUMAN	TEC_HUMAN	kinase -> substrate	NetPath
LYN_HUMAN	TEC_HUMAN	kinase -> substrate	NetPath
TEC_HUMAN	PLCG1_HUMAN	kinase -> substrate	NetPath
TEC_HUMAN	PLCG2_HUMAN	kinase -> substrate	NetPath
TEC_HUMAN	STAP1_HUMAN	kinase -> substrate	NetPath
TEC_HUMAN	PTN18_HUMAN	kinase -> substrate	RegPhos; NetPath
TEC_HUMAN	NAR4_HUMAN	kinase -> substrate	NetPath
TEC_HUMAN	BTK_HUMAN	kinase -> substrate	HPRD; RegPhos
BTK_HUMAN	TEC_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
ITK_HUMAN	TEC_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
TEC_HUMAN	BMX_HUMAN	kinase -> substrate	RegPhos
PTN18_HUMAN	TEC_HUMAN	phosphatase -> substrate	NetPath

KEGG Pathway

KEGG ID	Pathway
hsa04380	Osteoclast differentiation
hsa04660	T cell receptor signaling pathway

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0007229	integrin-mediated signaling pathway	IDA	biological_process
GO:0006468	protein phosphorylation	TAS	biological_process
GO:0010543	regulation of platelet activation	IDA	biological_process
GO:0004713	protein tyrosine kinase activity	IEA	molecular_function
GO:0005737	cytoplasm	IDA	cellular_component
GO:0004672	protein kinase activity	IEA	molecular_function
GO:0005829	cytosol	TAS	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0046872	metal ion binding	IEA	molecular_function
GO:0016772	transferase activity, transferring phosphorus-cont	IEA	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0007243	intracellular protein kinase cascade	TAS	biological_process
GO:0005543	phospholipid binding	IEA	molecular_function
GO:0004715	non-membrane spanning protein tyrosine kinase acti	IDA	molecular_function
GO:0005515	protein binding	IEA	molecular_function
GO:0005856	cytoskeleton	IDA	cellular_component
GO:0050853	B cell receptor signaling pathway	IDA	biological_process
GO:0035556	intracellular signal transduction	IEA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network