Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NELFB_HUMAN
Description:negative elongation factor complex member B [Source:HGNC Symbol;Acc:24324]
Location:chr9 q34.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T564AQAAEtPALELCOBRA1PhosphoSitePlus
S557DHRKPsPAQAAHPRD; phosphoELM; SysPTM
S557DHRKPsPAQAACOBRA1PhosphoSitePlus; SysPTM
T330LVGQEtLPRDSCOBRA1PhosphoSitePlus
T564AQAAEtPALELHPRD
T406VSYPNtLPESFHPRD
S573ELPLPsVPAPAHPRD; SysPTM

Dephosphorylation site
NELFB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000339495P394LCOSMICHead and Neck Cancer21798893
ENSP00000339495K364TCOSMICSkin Cancer21984974
ENSP00000339495G198SCOSMICSkin Cancer21984974
ENSP00000339495A268VCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000339495Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineDown0.2116319398

Hyperphosphorylation site
NELFB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DDR1_HUMANNELFB_HUMANkinase -> substrateRobert H Newman (2013)
BTK_HUMANNELFB_HUMANkinase -> substrateRobert H Newman (2013)
HIPK1_HUMANNELFB_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
NELFB_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0005634nucleusIDAcellular_component
GO:0016032viral reproductionTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0050434positive regulation of viral transcriptionTASbiological_process
GO:0032021NELF complexIDAcellular_component
GO:0006368transcription elongation from RNA polymerase II prTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0006366transcription from RNA polymerase II promoterTASbiological_process


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