Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PKNX1_HUMAN
Description:PBX/knotted 1 homeobox 1 [Source:HGNC Symbol;Acc:9022]
Location:chr21 q22.3
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S239IRIQNsQLQLQPhosphoSitePlus
S166SGEPGsPYSPVPhosphoSitePlus
S156KTKMNsETLLSPhosphoSitePlus

Dephosphorylation site
PKNX1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000291547V265IHPIColorectal Cancer16959974
ENSP00000291547E72KCOSMICHepatocellular Carcinoma21822264
ENSP00000291547D433GCOSMICOvarian Cancer21720365
ENSP00000291547V265ISjoblom2006, COSMICIntestines Cancer16959974

Differential expressed protein
PKNX1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PKNX1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK4_HUMANPKNX1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANPKNX1_HUMANkinase -> substrateRobert H Newman (2013)
CDK6_HUMANPKNX1_HUMANkinase -> substrateRobert H Newman (2013)
AURKB_HUMANPKNX1_HUMANkinase -> substrateRobert H Newman (2013)
HIPK4_HUMANPKNX1_HUMANkinase -> substrateRobert H Newman (2013)
PKNX1_HUMANUROK_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
PKNX1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0030218erythrocyte differentiationIEAbiological_process
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0001525angiogenesisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030097hemopoiesisIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0043010camera-type eye developmentIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0030217T cell differentiationIEAbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005667transcription factor complexIEAcellular_component
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process


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