Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:HSP72_HUMAN
Description:heat shock 70kDa protein 2 [Source:HGNC Symbol;Acc:5235]
Location:chr14 q23.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y16DLGTTySCVGVHSP70PhosphoSitePlus
T276ERAKRtLSSSTHSP70PhosphoSitePlus
T166DAGTItGLNVLHSP70PhosphoSitePlus
S280RTLSSsTQASIHSP70PhosphoSitePlus
Y42RTTPSyVAFTDHSP70PhosphoSitePlus
T39QGNRTtPSYVAHSP70PhosphoSitePlus
T67MNPTNtIFDAKHSP70PhosphoSitePlus
Y42RTTPSyVAFTDphosphoELM
T465GKFDLtGIPPAHSP70PhosphoSitePlus
T65VAMNPtNTIFDHSP70PhosphoSitePlus
S224IFEVKsTAGDTHSP70PhosphoSitePlus
T505KENKItITNDKHSP70PhosphoSitePlus
S122PEEISsMVLTKHPRD
T229STAGDtHLGGEHSP70PhosphoSitePlus
T159SQRQAtKDAGTHSP70PhosphoSitePlus
S121FPEEIsSMVLTHPRD
S41NRTTPsYVAFTHSP70PhosphoSitePlus
T268VRRLRtACERAHSP70PhosphoSitePlus
T301FYTSItRARFEHSP70PhosphoSitePlus
Y108KVQVEyKGETKHSP70PhosphoSitePlus
T634ASGGPtIEEVDPhosphoSitePlus
T126SSMVLtKMKEIHSP70PhosphoSitePlus
Y108KVQVEyKGETKphosphoELM
T112EYKGEtKTFFPHSP70PhosphoSitePlus
T164TKDAGtITGLNHSP70PhosphoSitePlus
T178IINEPtAAAIAHSP70PhosphoSitePlus

Dephosphorylation site
HSP72_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000247207E407KCOSMICOvarian Cancer21720365
ENSP00000378199S279LCOSMICSkin Cancer21984974
ENSP00000247207L513VCOSMICHead and Neck Cancer21798893
ENSP00000378199P469SCOSMICMelanoma
ENSP00000378199L513VCOSMICHead and Neck Cancer21798893
ENSP00000247207R275GCOSMICHead and Neck Cancer21798893
ENSP00000247207P469SCOSMICMelanoma
ENSP00000247207S279LCOSMICSkin Cancer21984974
ENSP00000378199E407KCOSMICOvarian Cancer21720365
ENSP00000378199R275GCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000247207Breast CancerTreatment (none vs. 17b-Estradiol treatment)cell lineUp2.118491314
ENSP00000247207LeukemiaCancer vs. Cancer (chronic vs. acute leukemia)cell lineUp17449014

Hyperphosphorylation site
HSP72_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LYN_HUMANHSP72_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANHSP72_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANHSP72_HUMANkinase -> substrateRobert H Newman (2013)
FAK2_HUMANHSP72_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
HSP72_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001673male germ cell nucleusIEAcellular_component
GO:0007286spermatid developmentIEAbiological_process
GO:0051082unfolded protein bindingTASmolecular_function
GO:0031662positive regulation of cyclin-dependent protein kiIEAbiological_process
GO:0051861glycolipid bindingIEAmolecular_function
GO:0007140male meiosisTASbiological_process
GO:0000902cell morphogenesisIEAbiological_process
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0007140male meiosisIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0007141male meiosis IIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0009986cell surfaceIEAcellular_component
GO:0036128CatSper complexIEAcellular_component
GO:0036128CatSper complexISScellular_component
GO:0070194synaptonemal complex disassemblyIEAbiological_process
GO:0006986response to unfolded proteinTASbiological_process
GO:0000795synaptonemal complexIEAcellular_component


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