Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SMC3_HUMAN
Description:structural maintenance of chromosomes 3 [Source:HGNC Symbol;Acc:2468]
Location:chr10 q25.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S886EDLDNsIDKTEHPRD
S1083ERGSGsQSSVPSMC_NPhosphoSitePlus; SysPTM
S1081ESERGsGSQSSSMC_NPhosphoSitePlus; SysPTM
S243KLDELsAKRETSMC_NPhosphoSitePlus
S787GTDLLsQLSLEHPRD; phosphoELM
T783KAELGtDLLSQSMC_NPhosphoSitePlus
S1074DEGEGsGESERSMC_NPhosphoSitePlus; SysPTM
Y669LTGGYyDTRKSSMC_NPhosphoSitePlus
S1081ESERGsGSQSSHPRD; SysPTM
S177KEESIsLMKETSMC_NPhosphoSitePlus
T773HAMEStRESLKSMC_NPhosphoSitePlus
S1116EMQQLsGGQKSHPRD
S1067VEGSQsQDEGESMC_NPhosphoSitePlus; SysPTM
Y831TRVETyLNENLSMC_NPhosphoSitePlus
S1086SGSQSsVPSVDSMC_NPhosphoSitePlus
S175ERKEEsISLMKHPRD
S85IIFDNsDNRLPphosphoELM
S1116EMQQLsGGQKSSMC_NPhosphoSitePlus
S175ERKEEsISLMKSMC_NPhosphoSitePlus
Y560GNRLFyHIVDSSMC_N; SMC_hingePhosphoSitePlus
Y668ALTGGyYDTRKSMC_NPhosphoSitePlus
S674YDTRKsRLELQSMC_NPhosphoSitePlus
S1067VEGSQsQDEGEHPRD; phosphoELM; SysPTM
Y213EELAQyQKWDKSMC_NPhosphoSitePlus
S731RKFKAsRDSILHPRD
S85IIFDNsDNRLPSMC_NPhosphoSitePlus
S1083ERGSGsQSSVPHPRD; phosphoELM; SysPTM
S731RKFKAsRDSILSMC_NPhosphoSitePlus
S1085GSGSQsSVPSVSMC_NPhosphoSitePlus
S1077EGSGEsERGSGSMC_NPhosphoSitePlus
S1013DRGYKsIMELMSMC_NPhosphoSitePlus
Y225RRALEyTIYNQSMC_NPhosphoSitePlus
S243KLDELsAKRETHPRD
S787GTDLLsQLSLESMC_NPhosphoSitePlus
T783KAELGtDLLSQHPRD
S737RDSILsEMKMLHPRD
Y979TELKKySHVNKSMC_NPhosphoSitePlus
S1074DEGEGsGESERHPRD; phosphoELM; SysPTM
T926ELEKMtNRQGMSMC_NPhosphoSitePlus
S177KEESIsLMKETHPRD
Y615ISKLRyNPRFDSMC_N; SMC_hingePhosphoSitePlus
Y600VRDTAyPETNDSMC_N; SMC_hingePhosphoSitePlus
S1065GDVEGsQSQDESMC_NPhosphoSitePlus
S1013DRGYKsIMELMHPRD
S1065GDVEGsQSQDEHPRD; phosphoELM
S886EDLDNsIDKTESMC_NPhosphoSitePlus

Dephosphorylation site
SMC3_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354720E343VTCGAOvarian Cancer21720365, 18772890
ENSP00000354720A44VCOSMICCentral Nervous System Neoplasms18772396
ENSP00000354720E343VCOSMICOvarian Cancer21720365
ENSP00000354720M648VCOSMICHead and Neck Cancer21798893
ENSP00000354720R944*COSMICMelanoma21499247
ENSP00000354720A163GCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000354720Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
SMC3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANSMC3_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSMC3_HUMANkinase -> substrateRobert H Newman (2013)
NEK6_HUMANSMC3_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANSMC3_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SMC3_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionIDAbiological_process
GO:0006275regulation of DNA replicationIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0000775chromosome, centromeric regionIEAcellular_component
GO:0000087M phase of mitotic cell cycleTASbiological_process
GO:0003777microtubule motor activityNASmolecular_function
GO:0006281DNA repairIEAbiological_process
GO:0005604basement membraneTAScellular_component
GO:0000922spindle poleIDAcellular_component
GO:0007091mitotic metaphase/anaphase transitionTASbiological_process
GO:0032876negative regulation of DNA endoreduplicationIMPbiological_process
GO:0005694chromosomeIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0051276chromosome organizationIEAbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0008278cohesin complexNAScellular_component
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0036033mediator complex bindingIEAmolecular_function
GO:0034991nuclear meiotic cohesin complexIEAcellular_component
GO:0016363nuclear matrixIDAcellular_component
GO:0019827stem cell maintenanceIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030893meiotic cohesin complexIDAcellular_component
GO:0045502dynein bindingIDAmolecular_function
GO:0007052mitotic spindle organizationIEPbiological_process
GO:0005634nucleusTAScellular_component
GO:0007062sister chromatid cohesionNASbiological_process
GO:0000785chromatinIDAcellular_component
GO:0007126meiosisIDAbiological_process
GO:0007067mitosisTASbiological_process
GO:0000800lateral elementIEAcellular_component
GO:0000236mitotic prometaphaseTASbiological_process