Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TTF2_HUMAN
Description:transcription termination factor, RNA polymerase II [Source:HGNC Symbol;Acc:12398]
Location:chr1 p13.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T349GREAAtSSDDEPhosphoSitePlus
S399KVSPAsGVSKKPhosphoSitePlus
S520TAGGSsQCYRGPhosphoSitePlus
T465SPEQGtNEKSNHPRD
S251DVQREsEPLREPhosphoSitePlus; HPRD
Y30KGKSFyVCRADzf-GRFPhosphoSitePlus
S908SEAADsPRSSTSNF2_NPhosphoSitePlus
S810GGERLsILTKSSNF2_NPhosphoSitePlus
S350REAATsSDDEEPhosphoSitePlus
S217HKRDFsEIKSQPhosphoSitePlus
S351EAATSsDDEEEPhosphoSitePlus
S396VQRKVsPASGVPhosphoSitePlus; HPRD
S368SSKPGsPLLFDPhosphoSitePlus; HPRD
T813RLSILtKSLLLSNF2_NPhosphoSitePlus
Y416VARRVyLTTQLPhosphoSitePlus
Y1036KHGLTyATIDGHelicase_CPhosphoSitePlus
S460SGLTLsPEQGTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T500LPRRGtQPVGSPhosphoSitePlus; HPRD
T286LNKEYtNWEAKPhosphoSitePlus
S810GGERLsILTKSHPRD
Y285PLNKEyTNWEAPhosphoSitePlus
S883NQSGRsPNNPFSNF2_NPhosphoSitePlus; SysPTM
S402PASGVsKKVEPPhosphoSitePlus; HPRD
S374PLLFDsTLDLEHPRD
Y523GSSQCyRGHTNPhosphoSitePlus
S221FSEIKsQQCQGPhosphoSitePlus
T1019IVSQWtNMLKVPhosphoSitePlus
T380TLDLEtKENLQPhosphoSitePlus; HPRD
S883NQSGRsPNNPFHPRD; phosphoELM; SysPTM
S908SEAADsPRSSTHPRD

Dephosphorylation site
TTF2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000358478E623QBIOMARTBreast Cancer21930507, 21930502
ENSP00000358478L958FTCGAOvarian Cancer21720365, 18772890
ENSP00000358478D373YCOSMICHepatocellular Carcinoma21822264
ENSP00000358478P299SCOSMICSkin Cancer21984974
ENSP00000358478L958FCOSMICOvarian Cancer21720365
ENSP00000358478L436FBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
TTF2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TTF2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANTTF2_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANTTF2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
TTF2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0008023transcription elongation factor complexTAScellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0008270zinc ion bindingIEAmolecular_function
GO:0006397mRNA processingIEAbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0006353DNA-dependent transcription, terminationTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005681spliceosomal complexIEAcellular_component
GO:0008094DNA-dependent ATPase activityTASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0004386helicase activityIEAmolecular_function
GO:0016787hydrolase activityIEAmolecular_function
GO:0008026ATP-dependent helicase activityIEAmolecular_function
GO:0008380RNA splicingIEAbiological_process
GO:0006369termination of RNA polymerase II transcriptionTASbiological_process
GO:0005634nucleusIDAcellular_component


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