Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PSA6_HUMAN
Description:proteasome (prosome, macropain) subunit, alpha type, 6 [Source:HGNC Symbol;Acc:9535]
Location:chr14 q13.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y160DPAGYyCGFKAHPRD; phosphoELM
Y160DPAGYyCGFKAProteasomePhosphoSitePlus
T73HLFKItENIGCProteasomePhosphoSitePlus
S17HITIFsPEGRLPhosphoSitePlus; HPRD
S5_MSRGsSAGFDPhosphoSitePlus
Y23PEGRLyQVEYAPhosphoSitePlus
Y107KYKYGyEIPVDProteasomePhosphoSitePlus
Y103AANWKyKYGYEProteasomePhosphoSitePlus
Y96VQRARyEAANWProteasomePhosphoSitePlus
Y105NWKYKyGYEIPProteasomePhosphoSitePlus
Y159CDPAGyYCGFKProteasomePhosphoSitePlus

Dephosphorylation site
PSA6_HUMAN do not have dephosphorylation site.

Mutation site
PSA6_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000261479Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineUp3.316319398
ENSP00000261479colorectal cancerNormal vs. CancertissueUp1.314997500
ENSP00000261479Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.220804217
ENSP00000261479Breast CancerNormal vs. CancertissueUp0.6320739354
ENSP00000261479Breast CancerNormal vs. CancertissueUp0.6320739354
ENSP00000261479acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp17655343

Hyperphosphorylation site
PSA6_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK40_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
KKCC1_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
TNI3K_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
KS6A4_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
STK16_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
AAPK2_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
IRAK3_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANPSA6_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PSA6_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000932cytoplasmic mRNA processing bodyISScellular_component
GO:0005634nucleusIDAcellular_component
GO:0051439regulation of ubiquitin-protein ligase activity inTASbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0051436negative regulation of ubiquitin-protein ligase acTASbiological_process
GO:0031145anaphase-promoting complex-dependent proteasomal uTASbiological_process
GO:0005844polysomeIDAcellular_component
GO:0005739mitochondrionIDAcellular_component
GO:0006521regulation of cellular amino acid metabolic procesTASbiological_process
GO:0000209protein polyubiquitinationTASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIMPbiological_process
GO:0005829cytosolTAScellular_component
GO:0016071mRNA metabolic processTASbiological_process
GO:0030016myofibrilIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0004175endopeptidase activityNASmolecular_function
GO:0030016myofibrilISScellular_component
GO:0005654nucleoplasmTAScellular_component
GO:0006511ubiquitin-dependent protein catabolic processNASbiological_process
GO:0050727regulation of inflammatory responseICbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0051059NF-kappaB bindingIPImolecular_function
GO:0000216M/G1 transition of mitotic cell cycleTASbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0000278mitotic cell cycleTASbiological_process
GO:0051603proteolysis involved in cellular protein catabolicIEAbiological_process
GO:0005839proteasome core complexIEAcellular_component
GO:0042590antigen processing and presentation of exogenous pTASbiological_process
GO:0006977DNA damage response, signal transduction by p53 clTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0004298threonine-type endopeptidase activityIEAmolecular_function
GO:0002474antigen processing and presentation of peptide antTASbiological_process
GO:0000075cell cycle checkpointTASbiological_process
GO:0016363nuclear matrixIEAcellular_component
GO:0002479antigen processing and presentation of exogenous pTASbiological_process
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0030017sarcomereIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0019773proteasome core complex, alpha-subunit complexTAScellular_component
GO:0035639purine ribonucleoside triphosphate bindingNASmolecular_function
GO:0034641cellular nitrogen compound metabolic processTASbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0051437positive regulation of ubiquitin-protein ligase acTASbiological_process
GO:0042981regulation of apoptotic processTASbiological_process


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