| UniProt/SwissProt ID: | ANM8_HUMAN |
| Description: | protein arginine methyltransferase 8 [Source:HGNC Symbol;Acc:5188] |
| Location: | chr12 p13.32 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S126 | GTGILsMFAAK | PrmA | PhosphoSitePlus |
| Y189 | SEWMGyCLFYE | PrmA | PhosphoSitePlus |
| Y193 | GYCLFyESMLN | PrmA | PhosphoSitePlus |
| Y222 | DRAALyVVAIE | PhosphoSitePlus | |
| S126 | GTGILsMFAAK | HPRD | |
| T122 | DVGSGtGILSM | HPRD | |
| Dephosphorylation site |
| ANM8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000372067 | R229K | COSMIC | Skin Cancer | 21984974 | ENSP00000372067 | I236T | COSMIC | Central Nervous System Neoplasms | 21163964 | ENSP00000372067 | I250M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000372067 | M247R | COSMIC | Ovarian Cancer | 21720365 | ENSP00000372067 | Q35R | COSMIC | Melanoma | 21499247 | ENSP00000372067 | L346P | COSMIC | Skin Cancer | 21984974 | ENSP00000372067 | W238* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000372067 | P56S | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| ANM8_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ANM8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TGFR2_HUMAN | ANM8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| ANM8_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0034969 | histone arginine methylation | IDA | biological_process |
| GO:0008152 | metabolic process | IEA | biological_process |
| GO:0019919 | peptidyl-arginine methylation, to asymmetrical-dim | IDA | biological_process |
| GO:0006479 | protein methylation | IEA | biological_process |
| GO:0043393 | regulation of protein binding | TAS | biological_process |
| GO:0035241 | protein-arginine omega-N monomethyltransferase act | IDA | molecular_function |
| GO:0035242 | protein-arginine omega-N asymmetric methyltransfer | IDA | molecular_function |
| GO:0016571 | histone methylation | IDA | biological_process |
| GO:0008168 | methyltransferase activity | IEA | molecular_function |
| GO:0008757 | S-adenosylmethionine-dependent methyltransferase a | IDA | molecular_function |
| GO:0008276 | protein methyltransferase activity | IEA | molecular_function |
| GO:0018216 | peptidyl-arginine methylation | IDA | biological_process |
| GO:0016740 | transferase activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0046982 | protein heterodimerization activity | IDA | molecular_function |
| GO:0042803 | protein homodimerization activity | IDA | molecular_function |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0008469 | histone-arginine N-methyltransferase activity | IDA | molecular_function |
| GO:0005886 | plasma membrane | IDA | cellular_component |