Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ERF1_HUMAN
Description:eukaryotic translation termination factor 1 [Source:HGNC Symbol;Acc:3477]
Location:chr5 q31.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S23KKLIKsLEAAReRF1_1PhosphoSitePlus
T208RKVAEtAVQLFHPRD
T32ARGNGtSMISLeRF1_1PhosphoSitePlus
S70RVNRLsVLGAIeRF1_1PhosphoSitePlus
S215VQLFIsGDKVNHPRD
S36GTSMIsLIIPPeRF1_1PhosphoSitePlus
T208RKVAEtAVQLFeRF1_2PhosphoSitePlus
S215VQLFIsGDKVNeRF1_2PhosphoSitePlus
S33RGNGTsMISLIeRF1_1PhosphoSitePlus
Y201EKRHNyVRKVAeRF1_2PhosphoSitePlus

Dephosphorylation site
ERF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000353741L126FCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000353741Hepatocellular CarcinomaNormal vs. Cancercell lineUp2.318646787

Hyperphosphorylation site
ERF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
DYRK4_HUMANERF1_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANERF1_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANERF1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANERF1_HUMANkinase -> substrateRobert H Newman (2013)
CDK4_HUMANERF1_HUMANkinase -> substrateRobert H Newman (2013)
KSYK_HUMANERF1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
ERF1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0006415translational terminationTASbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0006412translationTASbiological_process
GO:0003747translation release factor activityTASmolecular_function
GO:0044267cellular protein metabolic processTASbiological_process
GO:0016071mRNA metabolic processTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0008079translation termination factor activityTASmolecular_function
GO:0016149translation release factor activity, codon specifiIEAmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0006449regulation of translational terminationTASbiological_process
GO:0016070RNA metabolic processTASbiological_process
GO:0003723RNA bindingTASmolecular_function
GO:0043022ribosome bindingTASmolecular_function
GO:0006479protein methylationIDAbiological_process
GO:0000184nuclear-transcribed mRNA catabolic process, nonsenTASbiological_process


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