Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SMAD7_HUMAN
Description:SMAD family member 7 [Source:HGNC Symbol;Acc:6773]
Location:chr18 q21.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S117LQAVEsRGGTRMH1PhosphoSitePlus
T121ESRGGtRTACLMH1PhosphoSitePlus
T96DLKALtHSVLKMH1PhosphoSitePlus

Dephosphorylation site
SMAD7_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262158C160*COSMICOvarian Cancer21720365

Differential expressed protein
SMAD7_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SMAD7_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PDPK1_HUMANSMAD7_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANSMAD7_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSMAD7_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANSMAD7_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SMAD7_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0060389pathway-restricted SMAD protein phosphorylationIEAbiological_process
GO:0030514negative regulation of BMP signaling pathwayIDAbiological_process
GO:0032436positive regulation of proteasomal ubiquitin-depenIDAbiological_process
GO:0060412ventricular septum morphogenesisISSbiological_process
GO:0060412ventricular septum morphogenesisIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010467gene expressionTASbiological_process
GO:0055117regulation of cardiac muscle contractionISSbiological_process
GO:0070411I-SMAD bindingIPImolecular_function
GO:0050821protein stabilizationIDAbiological_process
GO:0060389pathway-restricted SMAD protein phosphorylationISSbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0033137negative regulation of peptidyl-serine phosphorylaIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0010944negative regulation of transcription by competitivIDAbiological_process
GO:0010801negative regulation of peptidyl-threonine phosphorIDAbiological_process
GO:0048844artery morphogenesisISSbiological_process
GO:0017015regulation of transforming growth factor beta receICbiological_process
GO:0005913cell-cell adherens junctionIDAcellular_component
GO:0030512negative regulation of transforming growth factor IDAbiological_process
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0048844artery morphogenesisIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0034629cellular protein complex localizationIDAbiological_process
GO:0034616response to laminar fluid shear stressIEPbiological_process
GO:0031625ubiquitin protein ligase bindingIEAmolecular_function
GO:0060373regulation of ventricular cardiac muscle cell membICbiological_process
GO:0030509BMP signaling pathwayTASbiological_process
GO:0055010ventricular cardiac muscle tissue morphogenesisISSbiological_process
GO:0008013beta-catenin bindingIPImolecular_function
GO:0030617transforming growth factor beta receptor, inhibitoIDAmolecular_function
GO:0005622intracellularIEAcellular_component
GO:0005667transcription factor complexIEAcellular_component
GO:0016342catenin complexIDAcellular_component
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0031398positive regulation of protein ubiquitinationIDAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0022409positive regulation of cell-cell adhesionIDAbiological_process
GO:0048185activin bindingIPImolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005518collagen bindingIEAmolecular_function
GO:0017015regulation of transforming growth factor beta receIEAbiological_process
GO:0010719negative regulation of epithelial to mesenchymal tICbiological_process
GO:0032925regulation of activin receptor signaling pathwayIDAbiological_process
GO:0001657ureteric bud developmentIEAbiological_process
GO:0051444negative regulation of ubiquitin-protein ligase acIDAbiological_process
GO:0005829cytosolTAScellular_component
GO:0030514negative regulation of BMP signaling pathwayIEAbiological_process
GO:0034333adherens junction assemblyIMPbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0034713type I transforming growth factor beta receptor biIPImolecular_function
GO:0043066negative regulation of apoptotic processTASbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0031397negative regulation of protein ubiquitinationIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0045944positive regulation of transcription from RNA polyTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0060394negative regulation of pathway-restricted SMAD proIDAbiological_process
GO:0055117regulation of cardiac muscle contractionIEAbiological_process
GO:0055010ventricular cardiac muscle tissue morphogenesisIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0043433negative regulation of sequence-specific DNA bindiIDAbiological_process
GO:0030336negative regulation of cell migrationTASbiological_process