Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FHL1_HUMAN
Description:four and a half LIM domains 1 [Source:HGNC Symbol;Acc:3702]
Location:chrX q26.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S51PIGADsKEVHYPhosphoSitePlus
Y207AVEDQyYCVDCPhosphoSitePlus

Dephosphorylation site
FHL1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000359724A168GCOSMICHead and Neck Cancer21798893
ENSP00000444815A168GCOSMICHead and Neck Cancer21798893
ENSP00000443333A168GCOSMICHead and Neck Cancer21798893
ENSP00000437673*310SCOSMICOvarian Cancer21720365
ENSP00000377709A168GCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000377710hepatitis C virusNormal vs. CancertissueUp9.618715028
ENSP00000377710Breast CancerNormal vs. CancertissueDown20560667

Hyperphosphorylation site
FHL1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TGFR2_HUMANFHL1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
FHL1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030308negative regulation of cell growthIDAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0009887organ morphogenesisNASbiological_process
GO:0010972negative regulation of G2/M transition of mitotic IDAbiological_process
GO:0003674molecular_functionNDmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0003254regulation of membrane depolarizationIDAbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0044325ion channel bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0043268positive regulation of potassium ion transportIDAbiological_process
GO:2000134negative regulation of G1/S transition of mitotic IDAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:1901016regulation of potassium ion transmembrane transporIDAbiological_process
GO:0007517muscle organ developmentNASbiological_process
GO:0005737cytoplasmIDAcellular_component


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