| UniProt/SwissProt ID: | RASA1_HUMAN |
| Description: | RAS p21 protein activator (GTPase activating protein) 1 [Source:HGNC Symbol;Acc:9871] |
| Location: | chr5 q14.3 |
| Node attribute: | substrate; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S827 | MESKQsCELSP | HPRD | |
| S650 | MESKQsCELSP | HPRD | |
| Y283 | DGKEIyNTIRR | EGFR | HPRD |
| Y460 | DGKEIyNTIRR | EGFR | HPRD; phosphoELM; RegPhos |
| T462 | KEIYNtIRRKT | PhosphoSitePlus | |
| T612 | PVKHFtNPYCN | C2 | PhosphoSitePlus |
| Y615 | HFTNPyCNIYL | C2 | PhosphoSitePlus |
| Y460 | DGKEIyNTIRR | LCK | HPRD; RegPhos |
| Y615 | HFTNPyCNIYL | HPRD; phosphoELM; RegPhos | |
| Y472 | TKDAFyKNIVK | PhosphoSitePlus | |
| Y438 | HFTNPyCNIYL | HPRD | |
| Y164 | LDGPEyEEEEV | PhosphoSitePlus | |
| Y283 | DGKEIyNTIRR | LCK | HPRD |
| S754 | RTLLAsILLRI | PhosphoSitePlus | |
| Y460 | DGKEIyNTIRR | PDGFR_group | phosphoELM; RegPhos |
| Y460 | DGKEIyNTIRR | PhosphoSitePlus | |
| T453 | QVLNDtVDGKE | PhosphoSitePlus | |
| Y952 | GAKEPyMEGVN | PhosphoSitePlus | |
| Y239 | AMCGDyYIGGR | SH2 | PhosphoSitePlus |
| Dephosphorylation site |
| RASA1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000274376 | G700C | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000274376 | R589H | COSMIC | Head and Neck Cancer | ENSP00000274376 | F959L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000274376 | K400G | OMIM | Neoplasms by Histologic Type | 8275088 | ENSP00000274376 | R1016H | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000274376 | A806D | COSMIC | Lung Cancer | 20668451 | ENSP00000274376 | K400E | HPI | Neoplasms by Histologic Type | 8275088 | ENSP00000274376 | Q882* | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000274376 | R398L | OMIM, HPI | Neoplasms by Histologic Type | 8275088 | ENSP00000274376 | I401V | OMIM, HPI | Neoplasms by Histologic Type | 8275088 | ENSP00000274376 | G700C | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| RASA1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RASA1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KSYK_HUMAN | RASA1_HUMAN | kinase -> substrate | NetPath |
| ZAGL2_HUMAN | RASA1_HUMAN | kinase -> substrate | RegPhos |
| EGFR_HUMAN | RASA1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| PGFRB_HUMAN | RASA1_HUMAN | kinase -> substrate | RegPhos |
| LCK_HUMAN | RASA1_HUMAN | kinase -> substrate | HPRD; RegPhos |
| RASA1_HUMAN | RRAS2_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04360 | Axon guidance |
| hsa04010 | MAPK signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0046580 | negative regulation of Ras protein signal transduc | IBA | biological_process |
| GO:0005099 | Ras GTPase activator activity | IBA | molecular_function |
| GO:0019870 | potassium channel inhibitor activity | NAS | molecular_function |
| GO:0051020 | GTPase binding | IPI | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0032320 | positive regulation of Ras GTPase activity | IBA | biological_process |
| GO:0001953 | negative regulation of cell-matrix adhesion | IDA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0030833 | regulation of actin filament polymerization | IDA | biological_process |
| GO:0031235 | intrinsic to internal side of plasma membrane | IBA | cellular_component |
| GO:0005096 | GTPase activator activity | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0001726 | ruffle | IEA | cellular_component |
| GO:0051056 | regulation of small GTPase mediated signal transdu | IEA | biological_process |
| GO:0001948 | glycoprotein binding | IPI | molecular_function |
| GO:0051252 | regulation of RNA metabolic process | NAS | biological_process |
| GO:0008360 | regulation of cell shape | NAS | biological_process |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0007162 | negative regulation of cell adhesion | IDA | biological_process |
| GO:0005102 | receptor binding | IPI | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0009790 | embryo development | ISS | biological_process |
| GO:0005737 | cytoplasm | IBA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0007165 | signal transduction | IDA | biological_process |
| GO:0043524 | negative regulation of neuron apoptotic process | ISS | biological_process |
| GO:0000910 | cytokinesis | ISS | biological_process |
| GO:0001570 | vasculogenesis | ISS | biological_process |
| GO:0035556 | intracellular signal transduction | NAS | biological_process |