Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:VAV_HUMAN
Description:vav 1 guanine nucleotide exchange factor [Source:HGNC Symbol;Acc:12657]
Location:chr19 p13.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S842VEEDYsEYC__PhosphoSitePlus
Y174EGDEIyEDLMRPhosphoSitePlus; phosphoELM
S113VIYTLsALSWTPhosphoSitePlus
Y826WRGEIyGRVGWSH3_1PhosphoSitePlus
Y174EGDEIyEDLMRLckRegPhos
S780RPAVGsTKYFGPhosphoSitePlus
Y844EDYSEphosphoELM
Y836WFPANyVEEDYPhosphoSitePlus
Y160EDEDLyDCVENLCKRegPhos
Y160EDEDLyDCVENLckphosphoELM; RegPhos
Y160EDEDLyDCVENPhosphoSitePlus; phosphoELM
Y783VGSTKyFGTAKPhosphoSitePlus
Y791TAKARyDFCARSH3_1PhosphoSitePlus
Y541LRGTFyQGYRCC1_1PhosphoSitePlus
Y192PKMTEyDKRCCPhosphoSitePlus
S285YGRYCsQVESARhoGEFPhosphoSitePlus
Y174EGDEIyEDLMRLCKRegPhos
Y142GDEDIySGLSDPhosphoSitePlus
Y745ELVEFyQQNSLSH2PhosphoSitePlus
Y142GDEDIySGLSDLckphosphoELM; RegPhos
Y142GDEDIySGLSDLCKRegPhos
S396ENLDQsLAHYGPhosphoSitePlus
Y280ERFLVyGRYCSRhoGEFPhosphoSitePlus
T574QDFPGtMKKDKPhosphoSitePlus
Y844EDYSEyCRegPhos
T786TKYFGtAKARYPhosphoSitePlus
Y267GAANLyQVFIKRhoGEFPhosphoSitePlus
Y110FGKVIyTLSALPhosphoSitePlus
Y844EDYSEyC____PhosphoSitePlus
Y841YVEEDySEYC_PhosphoSitePlus
Y603EVFQEyYGLPPPhosphoSitePlus
Y826WRGEIyGRVGWRegPhos

Dephosphorylation site
VAV_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000302269L801PDing2008, COSMICLung Cancer18948947
ENSP00000302269S459LCOSMICBreast Cancer20668451
ENSP00000302269D517ECOSMICLung Cancer20668451
ENSP00000302269R276KCOSMICMelanoma
ENSP00000302269D394GCOSMICOvarian Cancer21720365
ENSP00000302269Y482HCOSMICOvarian Cancer21720365
ENSP00000302269A264TCOSMICSkin Cancer21984974
ENSP00000302269R618WCOSMICHead and Neck Cancer21798893
ENSP00000302269E626KCOSMICRenal Cancer20054297
ENSP00000302269K435NCOSMICOvarian Cancer21720365
ENSP00000302269E59KDing2008, COSMICLung Cancer18948947

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000302269Uterine CancerTreatment(none vs. transfected with the pOP13 vector that containing E7)cell lineDown14997504

Hyperphosphorylation site
VAV_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FYN_HUMANVAV_HUMANkinase -> substrateNetPath
LCK_HUMANVAV_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
ZAGL2_HUMANVAV_HUMANkinase -> substrateRegPhos
KIT_HUMANVAV_HUMANkinase -> substrateNetPath
ZAP70_HUMANVAV_HUMANkinase -> substrateNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04662B cell receptor signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04510Focal adhesion
hsa04810Regulation of actin cytoskeleton
hsa04664Fc epsilon RI signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa04670Leukocyte transendothelial migration
hsa04062Chemokine signaling pathway
hsa04660T cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005622intracellularIEAcellular_component
GO:0035556intracellular signal transductionIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorTASmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0035023regulation of Rho protein signal transductionIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0006915apoptotic processTASbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0030168platelet activationTASbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0006355regulation of transcription, DNA-dependentTASbiological_process
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005085guanyl-nucleotide exchange factor activityTASmolecular_function


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