| UniProt/SwissProt ID: | CD3Z_HUMAN |
| Description: | CD247 molecule [Source:HGNC Symbol;Acc:1677] |
| Location: | chr1 q24.2 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y83 | GRREEyDVLDK | HPRD; phosphoELM; RegPhos | |
| Y110 | PQEGLyNELQK | HPRD | |
| Y141 | GHDGLyQGLST | HPRD | |
| T147 | YQGLStATKDT | ITAM | PhosphoSitePlus |
| Y122 | KMAEAySEIGM | HPRD | |
| Y111 | PQEGLyNELQK | Fyn | phosphoELM; RegPhos |
| T152 | TATKDtYDALH | ITAM | PhosphoSitePlus |
| Y64 | ADAPAyQQGQN | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y111 | PQEGLyNELQK | HPRD; phosphoELM; RegPhos | |
| S58 | VKFSRsADAPA | TCR_zetazeta | PhosphoSitePlus |
| Y72 | GQNQLyNELNL | ITAM | PhosphoSitePlus |
| Y142 | GHDGLyQGLST | ITAM | PhosphoSitePlus; SysPTM |
| S58 | VKFSRsADAPA | HPRD; phosphoELM; RegPhos | |
| Y152 | ATKDTyDALHM | HPRD | |
| Y153 | ATKDTyDALHM | ITAM | PhosphoSitePlus |
| Y123 | KMAEAySEIGM | Fyn | phosphoELM; RegPhos |
| S146 | LYQGLsTATKD | ITAM | PhosphoSitePlus |
| Y123 | KMAEAySEIGM | ITAM | PhosphoSitePlus |
| T149 | GLSTAtKDTYD | ITAM | PhosphoSitePlus |
| Y111 | PQEGLyNELQK | ITAM | PhosphoSitePlus |
| Y83 | GRREEyDVLDK | ITAM | PhosphoSitePlus |
| Y153 | ATKDTyDALHM | HPRD; phosphoELM; RegPhos | |
| Y142 | GHDGLyQGLST | HPRD; phosphoELM; RegPhos; SysPTM | |
| S124 | MAEAYsEIGMK | ITAM | PhosphoSitePlus |
| Y123 | KMAEAySEIGM | HPRD; phosphoELM; RegPhos | |
| Y72 | GQNQLyNELNL | HPRD; phosphoELM; RegPhos | |
| Dephosphorylation site |
| CD3Z_HUMAN do not have dephosphorylation site. |
| Mutation site |
| CD3Z_HUMAN do not have mutation site. |
| Differential expressed protein |
| CD3Z_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CD3Z_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FYN_HUMAN | CD3Z_HUMAN | kinase -> substrate | KEGG; NetPath; Robert H Newman (2013) |
| LCK_HUMAN | CD3Z_HUMAN | kinase -> substrate | NetPath |
| ZAGL2_HUMAN | CD3Z_HUMAN | kinase -> substrate | RegPhos |
| PTN6_HUMAN | CD3Z_HUMAN | phosphatase -> substrate | KEGG; NetPath |
| PTN3_HUMAN | CD3Z_HUMAN | phosphatase -> substrate | NetPath |
| ELF1_HUMAN | CD3Z_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04660 | T cell receptor signaling pathway |
| hsa04650 | Natural killer cell mediated cytotoxicity |
| hsa05142 | Chagas disease (American trypanosomiasis) |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0050852 | T cell receptor signaling pathway | IEA | biological_process |
| GO:0050690 | regulation of defense response to virus by virus | TAS | biological_process |
| GO:0031295 | T cell costimulation | TAS | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0042101 | T cell receptor complex | IEA | cellular_component |
| GO:0042802 | identical protein binding | IPI | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0050852 | T cell receptor signaling pathway | TAS | biological_process |
| GO:0050776 | regulation of immune response | TAS | biological_process |
| GO:0042101 | T cell receptor complex | IDA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0042803 | protein homodimerization activity | NAS | molecular_function |
| GO:0016032 | viral reproduction | TAS | biological_process |
| GO:0004888 | transmembrane signaling receptor activity | IEA | molecular_function |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005886 | plasma membrane | IDA | cellular_component |
| GO:0042105 | alpha-beta T cell receptor complex | IEA | cellular_component |
| GO:0007166 | cell surface receptor signaling pathway | IEA | biological_process |