Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CD3Z_HUMAN
Description:CD247 molecule [Source:HGNC Symbol;Acc:1677]
Location:chr1 q24.2
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y83GRREEyDVLDKHPRD; phosphoELM; RegPhos
Y110PQEGLyNELQKHPRD
Y141GHDGLyQGLSTHPRD
T147YQGLStATKDTITAMPhosphoSitePlus
Y122KMAEAySEIGMHPRD
Y111PQEGLyNELQKFynphosphoELM; RegPhos
T152TATKDtYDALHITAMPhosphoSitePlus
Y64ADAPAyQQGQNPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y111PQEGLyNELQKHPRD; phosphoELM; RegPhos
S58VKFSRsADAPATCR_zetazetaPhosphoSitePlus
Y72GQNQLyNELNLITAMPhosphoSitePlus
Y142GHDGLyQGLSTITAMPhosphoSitePlus; SysPTM
S58VKFSRsADAPAHPRD; phosphoELM; RegPhos
Y152ATKDTyDALHMHPRD
Y153ATKDTyDALHMITAMPhosphoSitePlus
Y123KMAEAySEIGMFynphosphoELM; RegPhos
S146LYQGLsTATKDITAMPhosphoSitePlus
Y123KMAEAySEIGMITAMPhosphoSitePlus
T149GLSTAtKDTYDITAMPhosphoSitePlus
Y111PQEGLyNELQKITAMPhosphoSitePlus
Y83GRREEyDVLDKITAMPhosphoSitePlus
Y153ATKDTyDALHMHPRD; phosphoELM; RegPhos
Y142GHDGLyQGLSTHPRD; phosphoELM; RegPhos; SysPTM
S124MAEAYsEIGMKITAMPhosphoSitePlus
Y123KMAEAySEIGMHPRD; phosphoELM; RegPhos
Y72GQNQLyNELNLHPRD; phosphoELM; RegPhos

Dephosphorylation site
CD3Z_HUMAN do not have dephosphorylation site.

Mutation site
CD3Z_HUMAN do not have mutation site.

Differential expressed protein
CD3Z_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CD3Z_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FYN_HUMANCD3Z_HUMANkinase -> substrateKEGG; NetPath; Robert H Newman (2013)
LCK_HUMANCD3Z_HUMANkinase -> substrateNetPath
ZAGL2_HUMANCD3Z_HUMANkinase -> substrateRegPhos
PTN6_HUMANCD3Z_HUMANphosphatase -> substrateKEGG; NetPath
PTN3_HUMANCD3Z_HUMANphosphatase -> substrateNetPath
ELF1_HUMANCD3Z_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04660T cell receptor signaling pathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05142Chagas disease (American trypanosomiasis)

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0050690regulation of defense response to virus by virusTASbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0042101T cell receptor complexIEAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0050776regulation of immune responseTASbiological_process
GO:0042101T cell receptor complexIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0042803protein homodimerization activityNASmolecular_function
GO:0016032viral reproductionTASbiological_process
GO:0004888transmembrane signaling receptor activityIEAmolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0042105alpha-beta T cell receptor complexIEAcellular_component
GO:0007166cell surface receptor signaling pathwayIEAbiological_process


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