Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CD28_HUMAN
Description:CD28 molecule [Source:HGNC Symbol;Acc:1653]
Location:chr2 q33.2
Node attribute:PPI(target); substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y218RDFAAyphosphoELM
Y218RDFAAyRSITKRegPhos
Y191LLHSDyMNMTPPhosphoSitePlus; phosphoELM; RegPhos
Y191LLHSDyMNMTPITKHPRD; phosphoELM; RegPhos
T195DYMNMtPRRPGPhosphoSitePlus
Y218RDFAAyITKHPRD; phosphoELM
Y209KHYQPyAPPRDPhosphoSitePlus; phosphoELM; RegPhos
Y206PTRKHyQPYAPITKHPRD; RegPhos
Y206PTRKHyQPYAPPhosphoSitePlus; phosphoELM; RegPhos
Y218RDFAAyRS___PhosphoSitePlus
Y209KHYQPyAPPRDITKHPRD; phosphoELM; RegPhos
S220FAAYRs_____PhosphoSitePlus
Y191LLHSDyMNMTPLckphosphoELM; RegPhos
S189SRLLHsDYMNMPhosphoSitePlus; HPRD

Dephosphorylation site
CD28_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000324890P121SCOSMICHead and Neck Cancer21984974

Differential expressed protein
CD28_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CD28_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ITK_HUMANCD28_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
LCK_HUMANCD28_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANCD28_HUMANkinase -> substrateRegPhos
CD86_HUMANCD28_HUMANotherKEGG
CD28_HUMANGRB2_HUMANotherKEGG
CD80_HUMANCD28_HUMANotherKEGG
CD28_HUMANCD80_HUMANotherKEGG
CD28_HUMANPI3R5_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05162Measles
hsa04940Type I diabetes mellitus
hsa05330Allograft rejection
hsa05416Viral myocarditis
hsa04672Intestinal immune network for IgA production
hsa04660T cell receptor signaling pathway
hsa05320Autoimmune thyroid disease
hsa05332Graft-versus-host disease
hsa04514Cell adhesion molecules (CAMs)
hsa05322Systemic lupus erythematosus
hsa05323Rheumatoid arthritis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0002863positive regulation of inflammatory response to anIEAbiological_process
GO:0042089cytokine biosynthetic processTASbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0002020protease bindingIPImolecular_function
GO:0015026coreceptor activityTASmolecular_function
GO:0050690regulation of defense response to virus by virusTASbiological_process
GO:0045727positive regulation of translationNASbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0048304positive regulation of isotype switching to IgG isIEAbiological_process
GO:0042802identical protein bindingNASmolecular_function
GO:0045066regulatory T cell differentiationIDAbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0045060negative thymic T cell selectionIEAbiological_process
GO:0009897external side of plasma membraneIEAcellular_component
GO:0042102positive regulation of T cell proliferationIDAbiological_process
GO:0005070SH3/SH2 adaptor activityIDAmolecular_function
GO:0045840positive regulation of mitosisIDAbiological_process
GO:0046641positive regulation of alpha-beta T cell proliferaIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045070positive regulation of viral genome replicationNASbiological_process
GO:0009897external side of plasma membraneIDAcellular_component
GO:0045086positive regulation of interleukin-2 biosynthetic IDAbiological_process
GO:0031295T cell costimulationIEAbiological_process
GO:0006959humoral immune responseTASbiological_process
GO:0005887integral to plasma membraneTAScellular_component


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