| UniProt/SwissProt ID: | HDAC8_HUMAN |
| Description: | histone deacetylase 8 [Source:HGNC Symbol;Acc:13315] |
| Location: | chrX q13.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S39 | IPKRAsMVHSL | PKACa | RegPhos |
| S39 | IPKRAsMVHSL | PKA_group | phosphoELM; RegPhos |
| S43 | ASMVHsLIEAY | Hist_deacetyl | PhosphoSitePlus |
| S39 | IPKRAsMVHSL | PRKACA | HPRD |
| Y48 | SLIEAyALHKQ | Hist_deacetyl | PhosphoSitePlus |
| S39 | IPKRAsMVHSL | Hist_deacetyl | PhosphoSitePlus |
| Y252 | VLKEVyQAFNP | Hist_deacetyl | PhosphoSitePlus |
| Dephosphorylation site |
| HDAC8_HUMAN do not have dephosphorylation site. |
| Mutation site |
| HDAC8_HUMAN do not have mutation site. |
| Differential expressed protein |
| HDAC8_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| HDAC8_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CDK7_HUMAN | HDAC8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCA_HUMAN | HDAC8_HUMAN | kinase -> substrate | HPRD |
| DYR1B_HUMAN | HDAC8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK1_HUMAN | HDAC8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| LCK_HUMAN | HDAC8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05034 | Alcoholism |
| hsa05203 | Viral carcinogenesis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | TAS | cellular_component |
| GO:0006333 | chromatin assembly or disassembly | TAS | biological_process |
| GO:0000122 | negative regulation of transcription from RNA poly | TAS | biological_process |
| GO:0097372 | NAD-dependent histone deacetylase activity (H3-K18 | IEA | molecular_function |
| GO:0016575 | histone deacetylation | IEA | biological_process |
| GO:0016787 | hydrolase activity | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0005634 | nucleus | TAS | cellular_component |
| GO:0005737 | cytoplasm | TAS | cellular_component |
| GO:0000118 | histone deacetylase complex | TAS | cellular_component |
| GO:0046969 | NAD-dependent histone deacetylase activity (H3-K9 | IEA | molecular_function |
| GO:0007062 | sister chromatid cohesion | IMP | biological_process |
| GO:0008134 | transcription factor binding | TAS | molecular_function |
| GO:0004407 | histone deacetylase activity | IEA | molecular_function |
| GO:0071922 | regulation of cohesin localization to chromatin | IMP | biological_process |
| GO:0046970 | NAD-dependent histone deacetylase activity (H4-K16 | IEA | molecular_function |
| GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 | IEA | molecular_function |
| GO:0016568 | chromatin modification | TAS | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |