UniProt/SwissProt ID: | FCG3A_HUMAN |
Description: | Fc fragment of IgG, low affinity IIIa, receptor (CD16a) [Source:HGNC Symbol;Acc:3619] |
Location: | chr1 q23.3 |
Node attribute: | kinase |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
T163 | YIPKAtLKDSG | ig | PhosphoSitePlus |
S167 | ATLKDsGSYFC | ig | PhosphoSitePlus |
S169 | LKDSGsYFCRG | ig | PhosphoSitePlus |
Y170 | KDSGSyFCRGL | ig | PhosphoSitePlus |
Dephosphorylation site |
FCG3A_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000356944 | E184Q | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000416607 | E184Q | BIOMART | Breast Cancer | 21930507, 21930502 |
Differential expressed protein |
Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
---|---|---|---|---|---|---|
ENSP00000416607 | Lung Cancer | Normal vs. Cancer | tissue | Up | 2.4 | 17705522 |
Hyperphosphorylation site |
FCG3A_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
FCG3A_HUMAN | LCK_HUMAN | kinase -> substrate | HPRD |
Function Annotation |
KEGG Pathway |
KEGG ID | Pathway |
---|---|
hsa04650 | Natural killer cell mediated cytotoxicity |
hsa05322 | Systemic lupus erythematosus |
hsa04666 | Fc gamma R-mediated phagocytosis |
hsa04145 | Phagosome |
hsa05152 | Tuberculosis |
hsa05150 | Staphylococcus aureus infection |
hsa04380 | Osteoclast differentiation |
hsa05140 | Leishmaniasis |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0050776 | regulation of immune response | TAS | biological_process |
GO:0019864 | IgG binding | IEA | molecular_function |
GO:0005576 | extracellular region | IEA | cellular_component |
GO:0009897 | external side of plasma membrane | IDA | cellular_component |
GO:0005515 | protein binding | IEA | molecular_function |
GO:0005886 | plasma membrane | TAS | cellular_component |
GO:0016021 | integral to membrane | IEA | cellular_component |
GO:0006955 | immune response | TAS | biological_process |