Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FCG3A_HUMAN
Description:Fc fragment of IgG, low affinity IIIa, receptor (CD16a) [Source:HGNC Symbol;Acc:3619]
Location:chr1 q23.3
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T163YIPKAtLKDSGigPhosphoSitePlus
S167ATLKDsGSYFCigPhosphoSitePlus
S169LKDSGsYFCRGigPhosphoSitePlus
Y170KDSGSyFCRGLigPhosphoSitePlus

Dephosphorylation site
FCG3A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000356944E184QBIOMARTBreast Cancer21930507, 21930502
ENSP00000416607E184QBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000416607Lung CancerNormal vs. CancertissueUp2.417705522

Hyperphosphorylation site
FCG3A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FCG3A_HUMANLCK_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04650Natural killer cell mediated cytotoxicity
hsa05322Systemic lupus erythematosus
hsa04666Fc gamma R-mediated phagocytosis
hsa04145Phagosome
hsa05152Tuberculosis
hsa05150Staphylococcus aureus infection
hsa04380Osteoclast differentiation
hsa05140Leishmaniasis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050776regulation of immune responseTASbiological_process
GO:0019864IgG bindingIEAmolecular_function
GO:0005576extracellular regionIEAcellular_component
GO:0009897external side of plasma membraneIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005886plasma membraneTAScellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0006955immune responseTASbiological_process


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