| UniProt/SwissProt ID: | SLAF1_HUMAN |
| Description: | signaling lymphocytic activation molecule family member 1 [Source:HGNC Symbol;Acc:10903] |
| Location: | chr1 q23.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y327 | NSITVyASVTL | PhosphoSitePlus | |
| S277 | TVEKKsLTIYA | PhosphoSitePlus | |
| Y281 | KSLTIyAQVQK | PhosphoSitePlus; phosphoELM | |
| T279 | EKKSLtIYAQV | PhosphoSitePlus | |
| Y307 | PCTTIyVAATE | Lck | phosphoELM; RegPhos |
| Y307 | PCTTIyVAATE | FYN | HPRD; RegPhos |
| Y307 | PCTTIyVAATE | Fyn | phosphoELM; RegPhos |
| Y327 | NSITVyASVTL | FYN | HPRD; RegPhos |
| Y281 | KSLTIyAQVQK | Fyn | phosphoELM; RegPhos |
| Y281 | KSLTIyAQVQK | FYN | HPRD; RegPhos |
| Y307 | PCTTIyVAATE | PhosphoSitePlus | |
| Y327 | NSITVyASVTL | Fyn | phosphoELM; RegPhos |
| Y327 | NSITVyASVTL | Lyn | phosphoELM; RegPhos |
| Dephosphorylation site |
| SLAF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000306190 | L81F | Sjoblom2006, COSMIC, HPI | Breast Cancer | 16959974 | ENSP00000306190 | T10I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000306190 | E167K | COSMIC | Skin Cancer | 21984974 | ENSP00000306190 | A282T | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| SLAF1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| SLAF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| FYN_HUMAN | SLAF1_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| LCK_HUMAN | SLAF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| LYN_HUMAN | SLAF1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05162 | Measles |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004872 | receptor activity | IEA | molecular_function |
| GO:0009986 | cell surface | IEA | cellular_component |
| GO:0004888 | transmembrane signaling receptor activity | TAS | molecular_function |
| GO:0008284 | positive regulation of cell proliferation | TAS | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0003823 | antigen binding | TAS | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0046649 | lymphocyte activation | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |