| UniProt/SwissProt ID: | IL2RB_HUMAN |
| Description: | interleukin 2 receptor, beta [Source:HGNC Symbol;Acc:6009] |
| Location: | chr22 q12.3 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T282 | VLKCNtPDPSK | PhosphoSitePlus | |
| Y387 | FTYDPySEEDP | Lck | phosphoELM; RegPhos |
| Y387 | FTYDPySEEDP | PhosphoSitePlus | |
| Y536 | LNTDAyLSLQE | Lck | phosphoELM; RegPhos |
| Y364 | FTNQGyFFFHL | JAK1 | HPRD; RegPhos |
| S293 | FFSQLsSEHGG | PhosphoSitePlus | |
| S458 | ERMPPsLQERV | PhosphoSitePlus | |
| Y364 | FTNQGyFFFHL | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y536 | LNTDAyLSLQE | PhosphoSitePlus | |
| Y418 | GEDDAyCTFPS | PhosphoSitePlus | |
| Y418 | GEDDAyCTFPS | Lck | phosphoELM; RegPhos |
| Y418 | GEDDAyCTFPS | LCK | HPRD; RegPhos |
| T105 | TVDIVtLRVLC | IL6Ra-bind; APOBEC_C | PhosphoSitePlus |
| Y381 | EACQVyFTYDP | PhosphoSitePlus | |
| Y387 | FTYDPySEEDP | LCK | HPRD; RegPhos |
| Y536 | LNTDAyLSLQE | LCK | HPRD; RegPhos |
| Y381 | EACQVyFTYDP | Lck | phosphoELM; RegPhos |
| Y381 | EACQVyFTYDP | LCK | HPRD; RegPhos |
| Y384 | QVYFTyDPYSE | PhosphoSitePlus | |
| Y384 | QVYFTyDPYSE | Lck | phosphoELM; RegPhos |
| Y384 | QVYFTyDPYSE | LCK | HPRD; RegPhos |
| Dephosphorylation site |
| IL2RB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000216223 | Y262* | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000216223 | D426E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000216223 | W152* | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| IL2RB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| IL2RB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | IL2RB_HUMAN | kinase -> substrate | RegPhos |
| JAK1_HUMAN | IL2RB_HUMAN | kinase -> substrate | HPRD; RegPhos; NetPath |
| LCK_HUMAN | IL2RB_HUMAN | kinase -> substrate | RegPhos; NetPath; Robert H Newman (2013) |
| PTN6_HUMAN | IL2RB_HUMAN | phosphatase -> substrate | NetPath |
| GABPA_HUMAN | IL2RB_HUMAN | TF -> target gene | TRANSFAC |
| ETS1_HUMAN | IL2RB_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa05166 | HTLV-I infection |
| hsa05202 | Transcriptional misregulation in cancer |
| hsa04630 | Jak-STAT signaling pathway |
| hsa04144 | Endocytosis |
| hsa05162 | Measles |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0019221 | cytokine-mediated signaling pathway | IDA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0038110 | interleukin-2-mediated signaling pathway | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0004911 | interleukin-2 receptor activity | TAS | molecular_function |
| GO:0043066 | negative regulation of apoptotic process | IDA | biological_process |
| GO:0006461 | protein complex assembly | TAS | biological_process |
| GO:0019976 | interleukin-2 binding | IEA | molecular_function |