Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CD3E_HUMAN
Description:CD3e molecule, epsilon (CD3-TCR complex) [Source:HGNC Symbol;Acc:1674]
Location:chr11 q23.3
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S77DKNIGsDEDHLIg_2PhosphoSitePlus
Y188VPNPDyEPIRKLCKHPRD; RegPhos
Y188VPNPDyEPIRKITAMPhosphoSitePlus
Y199GQRDLySGLNQITAMPhosphoSitePlus
S200QRDLYsGLNQRHPRD; RegPhos; SysPTM
Y188VPNPDyEPIRKphosphoELM; RegPhos
S83DEDHLsLKEFSIg_2PhosphoSitePlus
Y199GQRDLySGLNQLCKHPRD; RegPhos
Y199GQRDLySGLNQphosphoELM; RegPhos
S200QRDLYsGLNQRITAMPhosphoSitePlus; SysPTM

Dephosphorylation site
CD3E_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000354566Q204ETCGAOvarian Cancer21720365, 18772890
ENSP00000354566V134LTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000354566Q204ECOSMICOvarian Cancer21720365

Differential expressed protein
CD3E_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CD3E_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANCD3E_HUMANkinase -> substrateRegPhos
FYN_HUMANCD3E_HUMANkinase -> substrateKEGG
LCK_HUMANCD3E_HUMANkinase -> substrateRegPhos
TCF7_HUMANCD3E_HUMANTF -> target geneTRANSFAC
SOX9_HUMANCD3E_HUMANTF -> target geneTRANSFAC
SRY_HUMANCD3E_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04660T cell receptor signaling pathway
hsa04640Hematopoietic cell lineage
hsa05162Measles
hsa05166HTLV-I infection
hsa05340Primary immunodeficiency

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0009897external side of plasma membraneIEAcellular_component
GO:0006461protein complex assemblyNASbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0005057receptor signaling protein activityTASmolecular_function
GO:0007169transmembrane receptor protein tyrosine kinase sigTASbiological_process
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIEAbiological_process
GO:0050776regulation of immune responseTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0042101T cell receptor complexIDAcellular_component
GO:0045086positive regulation of interleukin-2 biosynthetic IEAbiological_process
GO:0045060negative thymic T cell selectionIEAbiological_process
GO:0007172signal complex assemblyTASbiological_process
GO:0045879negative regulation of smoothened signaling pathwaIEAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0004888transmembrane signaling receptor activityNASmolecular_function
GO:0019901protein kinase bindingNASmolecular_function
GO:0005887integral to plasma membraneNAScellular_component
GO:0042981regulation of apoptotic processNASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0016020membraneIEAcellular_component
GO:0004871signal transducer activityIEAmolecular_function
GO:0002669positive regulation of T cell anergyIEAbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0007166cell surface receptor signaling pathwayNASbiological_process
GO:0050870positive regulation of T cell activationIEAbiological_process
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0042102positive regulation of T cell proliferationIMPbiological_process
GO:0032753positive regulation of interleukin-4 productionIEAbiological_process
GO:0007584response to nutrientIEAbiological_process
GO:0042608T cell receptor bindingNASmolecular_function
GO:0050850positive regulation of calcium-mediated signalingIEAbiological_process
GO:0017124SH3 domain bindingIPImolecular_function
GO:0032729positive regulation of interferon-gamma productionIEAbiological_process
GO:0030159receptor signaling complex scaffold activityNASmolecular_function
GO:0042102positive regulation of T cell proliferationIEAbiological_process
GO:0042110T cell activationNASbiological_process
GO:0046649lymphocyte activationIEAbiological_process
GO:0033077T cell differentiation in thymusIEAbiological_process
GO:0007166cell surface receptor signaling pathwayIEAbiological_process
GO:0042105alpha-beta T cell receptor complexIEAcellular_component
GO:0009897external side of plasma membraneIDAcellular_component
GO:0001772immunological synapseIEAcellular_component
GO:0046641positive regulation of alpha-beta T cell proliferaIEAbiological_process