Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CTLA4_HUMAN
Description:cytotoxic T-lymphocyte-associated protein 4 [Source:HGNC Symbol;Acc:2505]
Location:chr2 q33.2
Node attribute:substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y201LTTGVyVKMPPTXKHPRD; phosphoELM; RegPhos
Y201LTTGVyVKMPPFYNHPRD; RegPhos
Y218KQFQPyFIPINPhosphoSitePlus
Y201LTTGVyVKMPPPhosphoSitePlus
Y201LTTGVyVKMPPJAK2HPRD; phosphoELM; RegPhos
Y201LTTGVyVKMPPLCKHPRD; RegPhos

Dephosphorylation site
CTLA4_HUMAN do not have dephosphorylation site.

Mutation site
CTLA4_HUMAN do not have mutation site.

Differential expressed protein
CTLA4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
CTLA4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
JAK2_HUMANCTLA4_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
LCK_HUMANCTLA4_HUMANkinase -> substrateHPRD; RegPhos; NetPath
FYN_HUMANCTLA4_HUMANkinase -> substrateHPRD; RegPhos; NetPath
TXK_HUMANCTLA4_HUMANkinase -> substrateHPRD; RegPhos
CD86_HUMANCTLA4_HUMANotherKEGG
CD80_HUMANCTLA4_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04514Cell adhesion molecules (CAMs)
hsa05320Autoimmune thyroid disease
hsa05323Rheumatoid arthritis
hsa04660T cell receptor signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006955immune responseIEAbiological_process
GO:0045590negative regulation of regulatory T cell differentIDAbiological_process
GO:0050853B cell receptor signaling pathwayIMPbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0045334clathrin-coated endocytic vesicleIDAcellular_component
GO:0006974response to DNA damage stimulusIMPbiological_process
GO:0009897external side of plasma membraneIDAcellular_component
GO:0031295T cell costimulationTASbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0005886plasma membraneTAScellular_component
GO:0043065positive regulation of apoptotic processIMPbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0030889negative regulation of B cell proliferationIMPbiological_process
GO:0009897external side of plasma membraneIEAcellular_component


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