Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:LCP2_HUMAN
Description:lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) [Source:HGNC Symbol;Acc:6529]
Location:chr5 q35.1
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y128EDDGDyESPNESykRegPhos
Y29FKKLNyKDCEKSAM_2PhosphoSitePlus
Y128EDDGDyESPNESYKphosphoELM
T341PMSSNtFPSRSPhosphoSitePlus
T454DSSKKtTTNPYSH2PhosphoSitePlus
Y113FEEDDyESPNDSYKphosphoELM
S376FPQSAsLPPYFHPK1(MAP4K1RegPhos
Y532THAAGyP____PhosphoSitePlus
S268FSDKPsIPAGRPhosphoSitePlus
Y128EDDGDyESPNEPhosphoSitePlus; phosphoELM
Y465VLMVLyKDKVYSH2PhosphoSitePlus
Y459TTTNPyVLMVLSH2PhosphoSitePlus
Y113FEEDDyESPNDTXKHPRD; RegPhos
Y128EDDGDyESPNELckphosphoELM
S106DNGGWsSFEEDPhosphoSitePlus
Y128EDDGDyESPNEZAP70HPRD; phosphoELM; RegPhos
Y476NIQIRyQKESQSH2PhosphoSitePlus
S344SNTFPsRSTKPPhosphoSitePlus
T227SRNHKtAKLPAPhosphoSitePlus
S376FPQSAsLPPYFMAP4K1phosphoELM
S207AGRNHsPLPPPPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
Y113FEEDDyESPNDLckphosphoELM
S107NGGWSsFEEDDPhosphoSitePlus
Y145EDDADyEPPPSZAP70HPRD; phosphoELM; RegPhos
Y423LNEEWyVSYITLCKHPRD; RegPhos
S376FPQSAsLPPYFPhosphoSitePlus
S130DGDYEsPNEEEPhosphoSitePlus; phosphoELM; RegPhos
S410KPRPPsPAEEEPhosphoSitePlus; phosphoELM; RegPhos
S339LLPMSsNTFPSPhosphoSitePlus
Y173NSNSMyIDRPPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S222EEPSRsRNHKTPhosphoSitePlus
Y423LNEEWyVSYITSH2PhosphoSitePlus
Y128EDDGDyESPNETXKHPRD; RegPhos
Y113FEEDDyESPNDSykRegPhos
Y145EDDADyEPPPSTXKphosphoELM; RegPhos
Y113FEEDDyESPNDZAP70HPRD; phosphoELM; RegPhos
S374SSFPQsASLPPPhosphoSitePlus
Y113FEEDDyESPNDPhosphoSitePlus; phosphoELM
S246PPLDRsLAPFDPhosphoSitePlus
S298RHERSsPLPGKPhosphoSitePlus
Y145EDDADyEPPPSPhosphoSitePlus; HPRD; RegPhos
Y483KESQVyLLGTGSH2PhosphoSitePlus
T455SSKKTtTNPYVSH2PhosphoSitePlus
S264KKPPFsDKPSIPhosphoSitePlus
Y39KAVKKyHIDGASAM_2PhosphoSitePlus
T428YVSYItRPEAESH2PhosphoSitePlus
T456SKKTTtNPYVLSH2PhosphoSitePlus
S169KPFPNsNSMYIPhosphoSitePlus
Y426EWYVSyITRPELCKHPRD; RegPhos
Y470YKDKVyNIQIRSH2PhosphoSitePlus
S220NHEEPsRSRNHPhosphoSitePlus
S171FPNSNsMYIDRPhosphoSitePlus
Y23DSLADyFKKLNRegPhos
S425EEWYVsYITRPSH2PhosphoSitePlus

Dephosphorylation site
LCP2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000046794A393DCOSMICOvarian Cancer21720365
ENSP00000046794P314QCOSMICHead and Neck Cancer21798893

Differential expressed protein
LCP2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
LCP2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LCK_HUMANLCP2_HUMANkinase -> substrateRegPhos; NetPath
FYN_HUMANLCP2_HUMANkinase -> substrateNetPath
ZAGL2_HUMANLCP2_HUMANkinase -> substrateRegPhos
KSYK_HUMANLCP2_HUMANkinase -> substrateKEGG; Robert H Newman (2013)
PTN6_HUMANLCP2_HUMANkinase -> substrateNetPath
TXK_HUMANLCP2_HUMANkinase -> substrateRegPhos
ZAP70_HUMANLCP2_HUMANkinase -> substrateRegPhos; NetPath; Robert H Newman (2013)
M4K1_HUMANLCP2_HUMANkinase -> substrateRegPhos
LCP2_HUMANVAV3_HUMANotherKEGG
LCP2_HUMANPLCG1_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04660T cell receptor signaling pathway
hsa04380Osteoclast differentiation
hsa04650Natural killer cell mediated cytotoxicity
hsa04664Fc epsilon RI signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050663cytokine secretionIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0030168platelet activationTASbiological_process
GO:0006955immune responseTASbiological_process
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigTASbiological_process
GO:0045576mast cell activationIEAbiological_process
GO:0007596blood coagulationTASbiological_process


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