Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FCG2A_HUMAN
Description:Fc fragment of IgG, low affinity IIa, receptor (CD32) [Source:HGNC Symbol;Acc:3616]
Location:chr1 q23.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y287TADGGyMTLNPSYKHPRD
Y288TADGGyMTLNPBLKphosphoELM; RegPhos
Y280ETNNDyETADGLYNHPRD
Y304DDKNIyLTLPPFYNRegPhos
Y288TADGGyMTLNPPhosphoSitePlus; phosphoELM
Y281ETNNDyETADGFynphosphoELM; RegPhos
Y304DDKNIyLTLPPSykRegPhos
Y288TADGGyMTLNPSYKphosphoELM; RegPhos
T297NPRAPtDDDKNPhosphoSitePlus
Y303DDKNIyLTLPPSYKHPRD
Y303DDKNIyLTLPPFYNHPRD
Y288TADGGyMTLNPLYNRegPhos
Y287TADGGyMTLNPLYNHPRD
T290DGGYMtLNPRAPhosphoSitePlus
Y240VVALIyCRKKRTMPhosphoSitePlus
Y303DDKNIyLTLPPLYNHPRD
Y304DDKNIyLTLPPSYKphosphoELM; RegPhos
Y288TADGGyMTLNPSykRegPhos
Y281ETNNDyETADGSykRegPhos
T283NNDYEtADGGYPhosphoSitePlus
Y281ETNNDyETADGLynphosphoELM; RegPhos
Y281ETNNDyETADGSYKphosphoELM; RegPhos
Y281ETNNDyETADGLYNRegPhos
Y304DDKNIyLTLPPPhosphoSitePlus
Y304DDKNIyLTLPPLynphosphoELM; RegPhos
Y304DDKNIyLTLPPBLKphosphoELM; RegPhos
Y281ETNNDyETADGFYNRegPhos
Y280ETNNDyETADGBLKHPRD
Y303DDKNIyLTLPPBLKHPRD
Y281ETNNDyETADGBLKphosphoELM; RegPhos
Y280ETNNDyETADGSYKHPRD
Y304DDKNIyLTLPPLYNRegPhos
Y288TADGGyMTLNPFynphosphoELM; RegPhos
Y288TADGGyMTLNPFYNRegPhos
Y281ETNNDyETADGPhosphoSitePlus
Y287TADGGyMTLNPBLKHPRD
Y304DDKNIyLTLPPFynphosphoELM; RegPhos
Y287TADGGyMTLNPFYNHPRD
T277RQLEEtNNDYEPhosphoSitePlus
Y288TADGGyMTLNPLynphosphoELM; RegPhos
Y280ETNNDyETADGFYNHPRD

Dephosphorylation site
FCG2A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000271450N178KBIOMARTBreast Cancer21930507, 21930502
ENSP00000356949N177KBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
FCG2A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FCG2A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
LYN_HUMANFCG2A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KSYK_HUMANFCG2A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FYN_HUMANFCG2A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
BLK_HUMANFCG2A_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04380Osteoclast differentiation
hsa05322Systemic lupus erythematosus
hsa05140Leishmaniasis
hsa05150Staphylococcus aureus infection
hsa05152Tuberculosis
hsa04145Phagosome
hsa04666Fc gamma R-mediated phagocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019864IgG bindingIEAmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0016021integral to membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function


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