Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BLNK_HUMAN
Description:B-cell linker [Source:HGNC Symbol;Acc:14211]
Location:chrHG339_PATCH q24.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T254GKKPTtPLKTTPhosphoSitePlus
Y84SDSEMyVMPAESykRegPhos
Y72DFDSDyENPDEPhosphoSitePlus; RegPhos
Y96NADDSyEPPPVSykRegPhos
Y178EDEADyVVPVESYKphosphoELM
Y96NADDSyEPPPVSYKphosphoELM
Y178EDEADyVVPVESykRegPhos
Y178EDEADyVVPVEPhosphoSitePlus; phosphoELM; RegPhos
Y84SDSEMyVMPAESYKphosphoELM
Y96NADDSyEPPPVPhosphoSitePlus; RegPhos
Y189DNDENyIHPTEPhosphoSitePlus; phosphoELM; RegPhos
Y72DFDSDyENPDESYKphosphoELM
Y84SDSEMyVMPAEPhosphoSitePlus; RegPhos
Y72DFDSDyENPDESykRegPhos

Dephosphorylation site
BLNK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000224337V180ICOSMICMelanoma21499247
ENSP00000224337S129FCOSMICMelanoma21499247
ENSP00000360218*434YCOSMICOvarian Cancer20826764

Differential expressed protein
BLNK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
BLNK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANBLNK_HUMANkinase -> substrateRegPhos
KSYK_HUMANBLNK_HUMANkinase -> substrateKEGG; NetPath; Robert H Newman (2013)
PTN6_HUMANBLNK_HUMANphosphatase -> substrateNetPath

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04662B cell receptor signaling pathway
hsa05340Primary immunodeficiency
hsa04380Osteoclast differentiation
hsa04064NF-kappa B signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007169transmembrane receptor protein tyrosine kinase sigTASbiological_process
GO:0006959humoral immune responseTASbiological_process
GO:0005622intracellularNAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005068transmembrane receptor protein tyrosine kinase adaTASmolecular_function
GO:0006954inflammatory responseTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005829cytosolTAScellular_component
GO:0005070SH3/SH2 adaptor activityRCAmolecular_function
GO:0030183B cell differentiationNASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0035556intracellular signal transductionIDAbiological_process


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